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Structures of Kibdelomycin Bound to Staphylococcus aureus GyrB and ParE Showed a Novel U‑Shaped Binding Mode

ACS chemical biology, 2014-09, Vol.9 (9), p.2023-2031

2014

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Contribution of Topoisomerase IV Mutation to Quinolone Resistance in Mycoplasma genitalium

Antimicrobial Agents and Chemotherapy, 2013-04, Vol.57 (4), p.1772-1776

2013

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Relationship between the expression of ompF and quinolone resistance in Escherichia coli

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2009-12, Vol.15 (6), p.361-366

2009

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Kibdelomycin is a bactericidal broad-spectrum aerobic antibacterial agent

Antimicrobial agents and chemotherapy, 2015-06, Vol.59 (6), p.3474-3481

2015

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Target Preference of 15 Quinolones against Staphylococcus aureus, Based on Antibacterial Activities and Target Inhibition

Antimicrobial Agents and Chemotherapy, 2001-12, Vol.45 (12), p.3544-3547

2001

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In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977)

Antimicrobial agents and chemotherapy, 2017-06, Vol.61 (6)

2017

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Structural and Functional Studies of the HAMP Domain of EnvZ, an Osmosensing Transmembrane Histidine Kinase in Escherichia coli

The Journal of biological chemistry, 2007-09, Vol.282 (36), p.26401-26408

2007

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Serum/glucocorticoid-regulated kinase 1 contributes to the proliferation of varicella-zoster virus and induction of cyclin B1 expression

Archives of virology, 2024-05, Vol.169 (5), p.116, Article 116

2024

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Contributions of the 8-Methoxy Group of Gatifloxacin to Resistance Selectivity, Target Preference, and Antibacterial Activity against Streptococcus pneumoniae

Antimicrobial Agents and Chemotherapy, 2001-06, Vol.45 (6), p.1649-1653

2001

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Contribution of the 8-Methoxy Group to the Activity of Gatifloxacin against Type II Topoisomerases of Streptococcus pneumoniae

Antimicrobial Agents and Chemotherapy, 2003-01, Vol.47 (1), p.77-81

2003

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Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.1045-1049

2017

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Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-9)

Bioorganic & medicinal chemistry letters, 2022-11, Vol.75, p.128808, Article 128808

2022

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LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents

ACS medicinal chemistry letters, 2016-06, Vol.7 (6), p.623-628

2016

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The effect of pharmacokinetic/pharmacodynamic (PK/PD) parameters of gatifloxacin on its bactericidal activity and resistance selectivity against clinical isolates of Streptococcus pneumoniae

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2003-09, Vol.9 (3), p.210-214

2003

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In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase

Antimicrobial agents and chemotherapy, 2016-08, Vol.60 (8), p.4830-4839

2016

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Oxabicyclooctane-Linked Novel Bacterial Topoisomerase Inhibitors as Broad Spectrum Antibacterial Agents

ACS medicinal chemistry letters, 2014-05, Vol.5 (5), p.609-614

2014

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Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2)

Bioorganic & medicinal chemistry letters, 2015-05, Vol.25 (9), p.1831-1835

2015

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Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3)

Bioorganic & medicinal chemistry letters, 2015-06, Vol.25 (12), p.2473-2478

2015

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Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5)

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (17), p.3630-3635

2015

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Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6)

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (17), p.3636-3643

2015

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Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4)

Bioorganic & medicinal chemistry letters, 2015-06, Vol.25 (11), p.2409-2415

2015

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C1–C2-linker substituted 1,5-naphthyridine analogues of oxabicyclooctane-linked NBTIs as broad-spectrum antibacterial agents (part 7)

MedChemComm, 2015-01, Vol.6 (10), p.1773-1780

2015

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Contribution of the C-8-methoxy group of gatifloxacin to inhibition of type II topoisomerases of Staphylococcus aureus

Antimicrobial agents and chemotherapy, 2002-10, Vol.46 (10), p.3337-3338

2002

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Structures of Kibdelomycin Bound to Staphylococcus aureus GyrB and ParE Showed a Novel U‑Shaped Binding Mode

Contribution of Topoisomerase IV Mutation to Quinolone Resistance in Mycoplasma genitalium

Relationship between the expression of ompF and quinolone resistance in Escherichia coli

Kibdelomycin is a bactericidal broad-spectrum aerobic antibacterial agent

Target Preference of 15 Quinolones against Staphylococcus aureus, Based on Antibacterial Activities and Target Inhibition

In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977)

Structural and Functional Studies of the HAMP Domain of EnvZ, an Osmosensing Transmembrane Histidine Kinase in Escherichia coli

Serum/glucocorticoid-regulated kinase 1 contributes to the proliferation of varicella-zoster virus and induction of cyclin B1 expression

Contributions of the 8-Methoxy Group of Gatifloxacin to Resistance Selectivity, Target Preference, and Antibacterial Activity against Streptococcus pneumoniae

Contribution of the 8-Methoxy Group to the Activity of Gatifloxacin against Type II Topoisomerases of Streptococcus pneumoniae

Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents

Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-9)

LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents

The effect of pharmacokinetic/pharmacodynamic (PK/PD) parameters of gatifloxacin on its bactericidal activity and resistance selectivity against clinical isolates of Streptococcus pneumoniae

In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase

Oxabicyclooctane-Linked Novel Bacterial Topoisomerase Inhibitors as Broad Spectrum Antibacterial Agents

Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2)

Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3)

Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5)

Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6)

Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4)

C1–C2-linker substituted 1,5-naphthyridine analogues of oxabicyclooctane-linked NBTIs as broad-spectrum antibacterial agents (part 7)

C1-C2-linker substituted 1,5-naphthyridine analogues of oxabicyclooctane-linked NBTIs as broad-spectrum antibacterial agents (part 7)Electronic supplementary information (ESI) available: Synthetic details of compounds and intermediates. See DOI: 10.1039/c5md00297d

Contribution of the C-8-methoxy group of gatifloxacin to inhibition of type II topoisomerases of Staphylococcus aureus

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