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Chemistry of mycolactones, the causative toxins of Buruli ulcer

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (17), p.6703-6708

2011

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Zirconium/Nickel‐Mediated One‐Pot Ketone Synthesis

Angewandte Chemie International Edition, 2017-08, Vol.56 (36), p.10791-10795

International ed. in English, 2017

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Further Studies on Ni/Zr-mediated One-pot Ketone Synthesis: Use of a Mixture of NiI- and NiII-catalysts Greatly Improves the Molar Ratio of Coupling Partners

Chemistry letters, 2019-08, Vol.48 (8), p.947-950

2019

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Unified, Efficient, and Scalable Synthesis of Halichondrins: Zirconium/Nickel‐Mediated One‐Pot Ketone Synthesis as the Final Coupling Reaction

Angewandte Chemie International Edition, 2017-08, Vol.56 (36), p.10796-10800

International ed. in English, 2017

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Total Synthesis of Halichondrin A, the Missing Member in the Halichondrin Class of Natural Products

Journal of the American Chemical Society, 2014-04, Vol.136 (13), p.5171-5176

2014

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Operationally Simple and Efficient Workup Procedure for TBAF-Mediated Desilylation: Application to Halichondrin Synthesis

Organic letters, 2007-02, Vol.9 (4), p.723-726

2007

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Selective Activation/Coupling of Polyhalogenated Nucleophiles in Ni/Cr-Mediated Reactions: Synthesis of C1–C19 Building Block of Halichondrin Bs

Journal of the American Chemical Society, 2015-05, Vol.137 (19), p.6219-6225

2015

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Concise and Highly Stereoselective Synthesis of the C20–C26 Building Block of Halichondrins and Eribulin

Organic letters, 2012-01, Vol.14 (2), p.660-663

2012

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Application of Ni/Zr-Mediated Ketone Coupling for the Scalable Synthesis of Homohalichondrin B

Organic letters, 2024-08, Vol.26 (34), p.7105-7109

2024

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A landmark in drug discovery based on complex natural product synthesis

Scientific reports, 2019-06, Vol.9 (1), p.8656-9, Article 8656

2019

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On Ni Catalysts for Catalytic, Asymmetric Ni/Cr-Mediated Coupling Reactions

Journal of the American Chemical Society, 2012-04, Vol.134 (14), p.6136-6139

2012

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Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for In vivo Efficacy under Intermittent Dosing Conditions

Cancer research (Chicago, Ill.), 2011-01, Vol.71 (2), p.496-505

2011

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Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer

PLoS neglected tropical diseases, 2017-08, Vol.11 (8), p.e0005834-e0005834

2017

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Dramatic Improvement in Catalyst Loadings and Molar Ratios of Coupling Partners for Ni/Cr-Mediated Coupling Reactions: Heterobimetallic Catalysts

Journal of the American Chemical Society, 2009-11, Vol.131 (46), p.16678-16680

2009

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Toolbox Approach to the Search for Effective Ligands for Catalytic Asymmetric Cr-Mediated Coupling Reactions

Journal of the American Chemical Society, 2009-10, Vol.131 (42), p.15387-15393

2009

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Catalytic Enantioselective Cr-Mediated Propargylation: Application to Halichondrin Synthesis

Organic letters, 2009-10, Vol.11 (20), p.4520-4523

2009

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Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389

Cancer research (Chicago, Ill.), 2004-08, Vol.64 (16), p.5760-5766

2004

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New Syntheses of E7389 C14−C35 and Halichondrin C14−C38 Building Blocks: Double-Inversion Approach

Journal of the American Chemical Society, 2009-11, Vol.131 (43), p.15636-15641

2009

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Simple, Rapid Mycobacterium ulcerans Disease Diagnosis from Clinical Samples by Fluorescence of Mycolactone on Thin Layer Chromatography

PLoS neglected tropical diseases, 2015-11, Vol.9 (11), p.e0004247-e0004247

2015

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New Syntheses of E7389 C14−C35 and Halichondrin C14−C38 Building Blocks: Reductive Cyclization and Oxy-Michael Cyclization Approaches

Journal of the American Chemical Society, 2009-11, Vol.131 (43), p.15642-15646

2009

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Fe/Cr- and Co/Cr-Mediated Catalytic Asymmetric 2-Haloallylations of Aldehydes

Journal of the American Chemical Society, 2004-10, Vol.126 (39), p.12248-12249

2004

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Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease

PLoS neglected tropical diseases, 2015-06, Vol.9 (6), p.e0003823

2015

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Catalytic Ni/Cr-Mediated Macrocyclization without Use of High-Dilution Techniques

Journal of the American Chemical Society, 2005-11, Vol.127 (44), p.15382-15383

2005

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Total Synthesis and Stereochemistry of Mycolactone F

Journal of the American Chemical Society, 2008-02, Vol.130 (6), p.1842-1844

2008

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Iterative Cr-Mediated Catalytic Asymmetric Allylation To Synthesize syn/syn- and anti/anti-1,3,5-Triols

Organic letters, 2008-07, Vol.10 (14), p.3077-3080

2008

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Chemistry of mycolactones, the causative toxins of Buruli ulcer

Zirconium/Nickel‐Mediated One‐Pot Ketone Synthesis

Further Studies on Ni/Zr-mediated One-pot Ketone Synthesis: Use of a Mixture of NiI- and NiII-catalysts Greatly Improves the Molar Ratio of Coupling Partners

Unified, Efficient, and Scalable Synthesis of Halichondrins: Zirconium/Nickel‐Mediated One‐Pot Ketone Synthesis as the Final Coupling Reaction

Total Synthesis of Halichondrin A, the Missing Member in the Halichondrin Class of Natural Products

Operationally Simple and Efficient Workup Procedure for TBAF-Mediated Desilylation: Application to Halichondrin Synthesis

Selective Activation/Coupling of Polyhalogenated Nucleophiles in Ni/Cr-Mediated Reactions: Synthesis of C1–C19 Building Block of Halichondrin Bs

Concise and Highly Stereoselective Synthesis of the C20–C26 Building Block of Halichondrins and Eribulin

Application of Ni/Zr-Mediated Ketone Coupling for the Scalable Synthesis of Homohalichondrin B

A landmark in drug discovery based on complex natural product synthesis

On Ni Catalysts for Catalytic, Asymmetric Ni/Cr-Mediated Coupling Reactions

Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for In vivo Efficacy under Intermittent Dosing Conditions

Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer

Dramatic Improvement in Catalyst Loadings and Molar Ratios of Coupling Partners for Ni/Cr-Mediated Coupling Reactions: Heterobimetallic Catalysts

Toolbox Approach to the Search for Effective Ligands for Catalytic Asymmetric Cr-Mediated Coupling Reactions

Catalytic Enantioselective Cr-Mediated Propargylation: Application to Halichondrin Synthesis

Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389

New Syntheses of E7389 C14−C35 and Halichondrin C14−C38 Building Blocks: Double-Inversion Approach

Simple, Rapid Mycobacterium ulcerans Disease Diagnosis from Clinical Samples by Fluorescence of Mycolactone on Thin Layer Chromatography

New Syntheses of E7389 C14−C35 and Halichondrin C14−C38 Building Blocks: Reductive Cyclization and Oxy-Michael Cyclization Approaches

Fe/Cr- and Co/Cr-Mediated Catalytic Asymmetric 2-Haloallylations of Aldehydes

Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease

Catalytic Ni/Cr-Mediated Macrocyclization without Use of High-Dilution Techniques

Total Synthesis and Stereochemistry of Mycolactone F

Iterative Cr-Mediated Catalytic Asymmetric Allylation To Synthesize syn/syn- and anti/anti-1,3,5-Triols

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