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Synthesis and Evaluation of in Vivo Anti-hypothermic Effect of the N- and C-Terminus Modified Thyrotropin-Releasing Hormone Mimetic: [(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-[3-(thiazol-4-yl)-L-alanyl]-L-prolinamide

Chemical and Pharmaceutical Bulletin, 2021/04/01, Vol.69(4), pp.314-324

2021

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Effects of Naldemedine: A Peripherally Acting Mu-Opioid Receptor Antagonist in Rat Models of Opioid-Induced Constipation: 1322

The American journal of gastroenterology, 2015-10, Vol.110, p.S578

2015

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Morphine, Oxycodone, and Fentanyl Exhibit Different Analgesic Profiles in Mouse Pain Models

Journal of Pharmacological Sciences, 2009, Vol.111(1), pp.60-72

2009

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Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1‑{N‑[(4S,5S)‑(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)‑l‑alanyl}-(2R)‑2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate)

ACS omega, 2018-10, Vol.3 (10), p.13647-13666

2018

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Correction to Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1‑{N‑[(4S,5S)‑(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)‑l‑alanyl}-(2R)‑2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate)

ACS omega, 2019-04, Vol.4 (4), p.6977-6978

2019

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Role of neutrophils in radical production during ischemia and reperfusion of the rat brain: effect of neutrophil depletion on extracellular ascorbyl radical formation

Journal of cerebral blood flow and metabolism, 1995-11, Vol.15 (6), p.941-947

1995

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Distinct Relations Among Plasma Concentrations Required for Different Pharmacological Effects in Oxycodone, Morphine, and Fentanyl

Journal of pain & palliative care pharmacotherapy, 2011-11, Vol.25 (4), p.318-334

2011

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Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation

Neurogastroenterology and motility, 2019-05, Vol.31 (5), p.e13563-n/a

2019

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Oxycodone-Induced Analgesic Effects in a Bone Cancer Pain Model in Mice

Oncology, 2008-01, Vol.74 (Suppl 1), p.55-60

2008

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BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice2

Journal of neurochemistry, 2006-12, Vol.99 (6), p.1555-1563

2006

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Role of platelet-activating factor and thromboxane A2 in radical production during ischemia and reperfusion of the rat brain

Brain research, 1996-02, Vol.709 (2), p.296-302

1996

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PRECLINICAL MULTI-SPECIES PHARMACOKINETIC/PHARMACODYNAMIC ANALYSIS OF THE ORAL BACE INHIBITOR JNJ-54861911

Alzheimer's & dementia, 2017-07, Vol.13 (7), p.P266-P267

2017

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BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice

Journal of neurochemistry, 2006-12, Vol.99 (6), p.1555-1563

2006

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Direct Detection of Ascorbyl Radical in Experimental Brain Injury: Microdialysis and an Electron Spin Resonance Spectroscopic Study

Journal of neurochemistry, 1995-07, Vol.65 (1), p.282-286

1995

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Ultrastructural study of M cells from colonic lymphoid nodules obtained by colonoscopic biopsy

Digestive diseases and sciences, 1992-07, Vol.37 (7), p.1089-1098

1992

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Juvenile Polyposis Occurring in Hereditary Hemorrhagic Telangiectasia

The American journal of the medical sciences, 1999-01, Vol.317 (1), p.59-62

1999

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Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion

Stroke (1970), 1994-07, Vol.25 (7), p.1469-1475

1994

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Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat

Brain research, 1994-09, Vol.656 (2), p.344-352

1994

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S3B2-3 Development of a bone cancer pain model in mice and re-evaluation of analgesic effect of opioids

Journal of Pharmacological Sciences, 2008, Vol.106 (suppl.1), p.45-45

2008

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Liposidolide A, a New Antifungal Macrolide Antibiotic

The Journal of Antibiotics, 1995/11/25, Vol.48(11), pp.1385-1387

1995

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A NEW ANTIBIOTIC, TAUTOMYCIN

The Journal of Antibiotics, 1987/06/25, Vol.40(6), pp.907-909

1987

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O2G4-1 Studies on drug dependence (Rept. 429)：Characterization of tolerance to anti- hyperalgesic effects induced by chronic treatment with morphine, oxycodone and fentanyl under a neuropathic pain-like state in mice

Journal of Pharmacological Sciences, 2008, Vol.106 (suppl.1), p.92-92

2008

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P2-049 Neuroprotective effects of 2-(2-hydroxylphenyl)benzoxazol derivatives via induction of brain-derived neurotrophic factor synthesis

Journal of Pharmacological Sciences, 2007, Vol.103 (suppl.2), p.185-185

2007

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Evidence for the dissociation of morphine analgesia, tolerance and dependence

Journal of pharmacy and pharmacology, 1985-07, Vol.37 (7), p.507-508

1985

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BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice 2

Journal of neurochemistry, 2006-12, Vol.99 (6), p.1555-1563

2006

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Synthesis and Evaluation of in Vivo Anti-hypothermic Effect of the N- and C-Terminus Modified Thyrotropin-Releasing Hormone Mimetic: [(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-[3-(thiazol-4-yl)-L-alanyl]-L-prolinamide

Effects of Naldemedine: A Peripherally Acting Mu-Opioid Receptor Antagonist in Rat Models of Opioid-Induced Constipation: 1322

Morphine, Oxycodone, and Fentanyl Exhibit Different Analgesic Profiles in Mouse Pain Models

Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1‑{N‑[(4S,5S)‑(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)‑l‑alanyl}-(2R)‑2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate)

Correction to Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1‑{N‑[(4S,5S)‑(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)‑l‑alanyl}-(2R)‑2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate)

Role of neutrophils in radical production during ischemia and reperfusion of the rat brain: effect of neutrophil depletion on extracellular ascorbyl radical formation

Distinct Relations Among Plasma Concentrations Required for Different Pharmacological Effects in Oxycodone, Morphine, and Fentanyl

Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation

Oxycodone-Induced Analgesic Effects in a Bone Cancer Pain Model in Mice

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice2

Role of platelet-activating factor and thromboxane A2 in radical production during ischemia and reperfusion of the rat brain

PRECLINICAL MULTI-SPECIES PHARMACOKINETIC/PHARMACODYNAMIC ANALYSIS OF THE ORAL BACE INHIBITOR JNJ-54861911

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice

Direct Detection of Ascorbyl Radical in Experimental Brain Injury: Microdialysis and an Electron Spin Resonance Spectroscopic Study

Ultrastructural study of M cells from colonic lymphoid nodules obtained by colonoscopic biopsy

Juvenile Polyposis Occurring in Hereditary Hemorrhagic Telangiectasia

Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion

Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat

S3B2-3 Development of a bone cancer pain model in mice and re-evaluation of analgesic effect of opioids

Liposidolide A, a New Antifungal Macrolide Antibiotic

A NEW ANTIBIOTIC, TAUTOMYCIN

O2G4-1 Studies on drug dependence (Rept. 429)：Characterization of tolerance to anti- hyperalgesic effects induced by chronic treatment with morphine, oxycodone and fentanyl under a neuropathic pain-like state in mice

P2-049 Neuroprotective effects of 2-(2-hydroxylphenyl)benzoxazol derivatives via induction of brain-derived neurotrophic factor synthesis

Evidence for the dissociation of morphine analgesia, tolerance and dependence

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice 2

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