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Synthesis of Versatile Chiral N,P Ligands Derived from Pyridine and Quinoline

Angewandte Chemie International Edition, 2004-01, Vol.43 (1), p.70-74

2004

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The Tethered Aminohydroxylation (TA) of Cyclic Allylic Carbamates

Journal of the American Chemical Society, 2002-11, Vol.124 (44), p.12934-12935

2002

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Enantioselective Heck reactions using chiral P,N-ligands

Journal of Organometallic Chemistry, 1999-03, Vol.576 (1), p.16-22

1999

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The regioselective aminohydroxylation of allylic carbamates

Chemical communications (Cambridge, England), 2001-10 (20), p.2078-2079

2001

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A new era for chagas disease drug discovery?

Progress in medicinal chemistry, 2015, Vol.54, p.185-230

2015

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Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity

The Journal of biological chemistry, 2013-11, Vol.288 (44), p.31602-31615

2013

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Short-course combination treatment for experimental chronic Chagas disease

Science translational medicine, 2023-12, Vol.15 (726), p.eadg8105

2023

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Boron-based drugs as antiprotozoals

Current opinion in infectious diseases, 2011-12, Vol.24 (6), p.586-592

2011

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Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy

European journal of medicinal chemistry, 2020-12, Vol.207, p.112849, Article 112849

2020

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Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease

Journal of medicinal chemistry, 2012-05, Vol.55 (9), p.4189-4204

2012

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Two Analogues of Fenarimol Show Curative Activity in an Experimental Model of Chagas Disease

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10158-10170

2013

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Highly efficient and flexible total synthesis of coelenterazine

Chemical communications (Cambridge, England), 1997 (3), p.323-324

1997

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New facile and mild synthesis of 2-substituted oxazolopyridines

Tetrahedron letters, 2005-12, Vol.46 (52), p.9001-9004

2005

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Complexes of Trypanosoma cruzi Sterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease

The Journal of biological chemistry, 2013-11, Vol.288 (44), p.31602-31615

2013

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Design, structure–activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi

Bioorganic & medicinal chemistry, 2013-04, Vol.21 (7), p.1756-1763

2013

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Contra-Friedel-Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation

Chemical communications (Cambridge, England), 2006-01 (13), p.1393-1394

2006

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Asymmetric Ortholithiation of Amides by Conformationally Mediated Chiral Memory: An Enantioselective Route to Naphtho- and Benzofuranones

Synlett, 2005-07, Vol.2005 (11), p.1716-1720

2005

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Efficient Acyclic Stereocontrol Using the Tethered Aminohydroxylation Reaction

Organic letters, 2004-07, Vol.6 (15), p.2583-2585

2004

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Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi

Future medicinal chemistry, 2013-10, Vol.5 (15), p.1733-1752

2013

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Concise and Enantioselective Synthesis of the Aminocyclitol Core of Hygromycin A

Organic letters, 2005-03, Vol.7 (7), p.1275-1277

2005

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Synthesis of Versatile Chiral N,P Ligands Derived from Pyridine and Quinoline

Angewandte Chemie, 2004-01, Vol.116 (1), p.72-76

2004

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Addition of Lithiated Tertiary Aromatic Amides to Epoxides and Aziridines: Asymmetric Synthesis of (S)-(+)-Mellein

Synlett, 2006-04, Vol.2006 (6), p.873-876

2006

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High affinity ligands for the α7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4727-4730

2005

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Designing Drugs to Target Trypanosoma cruzi, the Etiological Agent of Chagas Disease: When Chemistry needs Biology

Neglected Tropical Diseases, 2019, p.93-113

2019

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Synthesis of Versatile Chiral N,P Ligands Derived from Pyridine and Quinoline

The Tethered Aminohydroxylation (TA) of Cyclic Allylic Carbamates

Enantioselective Heck reactions using chiral P,N-ligands

The regioselective aminohydroxylation of allylic carbamates

A new era for chagas disease drug discovery?

Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity

Short-course combination treatment for experimental chronic Chagas disease

Boron-based drugs as antiprotozoals

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc 1

Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy

Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease

Two Analogues of Fenarimol Show Curative Activity in an Experimental Model of Chagas Disease

Highly efficient and flexible total synthesis of coelenterazine

New facile and mild synthesis of 2-substituted oxazolopyridines

Complexes of Trypanosoma cruzi Sterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease

Design, structure–activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi

Contra-Friedel-Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation

Asymmetric Ortholithiation of Amides by Conformationally Mediated Chiral Memory: An Enantioselective Route to Naphtho- and Benzofuranones

Efficient Acyclic Stereocontrol Using the Tethered Aminohydroxylation Reaction

Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi

Concise and Enantioselective Synthesis of the Aminocyclitol Core of Hygromycin A

Synthesis of Versatile Chiral N,P Ligands Derived from Pyridine and Quinoline

Addition of Lithiated Tertiary Aromatic Amides to Epoxides and Aziridines: Asymmetric Synthesis of (S)-(+)-Mellein

High affinity ligands for the α7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor

Designing Drugs to Target Trypanosoma cruzi, the Etiological Agent of Chagas Disease: When Chemistry needs Biology

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