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Pharmacokinetic and metabolomic studies with a BIO 300 Oral Powder formulation in nonhuman primates

Scientific reports, 2022-08, Vol.12 (1), p.13475-13475, Article 13475

2022

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Pharmacokinetic and Metabolomic Studies with BIO 300, a Nanosuspension of Genistein, in a Nonhuman Primate Model

International journal of molecular sciences, 2019-03, Vol.20 (5), p.1231

2019

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BIO 300 Attenuates Whole Blood Transcriptome Changes in Mice Exposed to Total-Body Radiation

International journal of molecular sciences, 2024-08, Vol.25 (16), p.8818

2024

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Targeted Metabolomics Identifies Pharmacodynamic Biomarkers for BIO 300 Mitigation of Radiation-Induced Lung Injury

Pharmaceutical research, 2017-12, Vol.34 (12), p.2698-2709

2017

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Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome

Journal of radiation research, 2019-05, Vol.60 (3), p.308-317

2019

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Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease

Human gene therapy, 2016-07, Vol.27 (7), p.509-521

2016

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Microbiome study in irradiated mice treated with BIO 300, a promising radiation countermeasure

Animal microbiome, 2021-10, Vol.3 (1), p.71-71, Article 71

2021

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Serine 776 of Ataxin-1 Is Critical for Polyglutamine-Induced Disease in SCA1 Transgenic Mice

Neuron (Cambridge, Mass.), 2003-05, Vol.38 (3), p.375-387

2003

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BIO 300, a nanosuspension of genistein, mitigates pneumonitis/fibrosis following high‐dose radiation exposure in the C57L/J murine model

British journal of pharmacology, 2017-12, Vol.174 (24), p.4738-4750

2017

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A novel oral formulation of BIO 300 confers prophylactic radioprotection from acute radiation syndrome in mice

International journal of radiation biology, 2022-05, Vol.98 (5), p.958-967

2022

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A C57L/J Mouse Model of the Delayed Effects of Acute Radiation Exposure in the Context of Evolving Multi-Organ Dysfunction and Failure after Total-Body Irradiation with 2.5% Bone Marrow Sparing

Radiation research, 2023-04, Vol.199 (4), p.319

2023

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BIO 300, a Nanosuspension of Genistein, Mitigates Radiation-Induced Erectile Dysfunction and Sensitizes Human Prostate Cancer Xenografts to Radiation Therapy

International journal of radiation oncology, biology, physics, 2019-10, Vol.105 (2), p.400-409

2019

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Multicenter Phase 1b/2a Clinical Trial of Radioprotectant BIO 300 Oral Suspension for Patients With Non-Small Cell Lung Cancer Receiving Concurrent Chemoradiotherapy

International journal of radiation oncology, biology, physics, 2024-02, Vol.118 (2), p.404-414

2024

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Interspecies Comparison and Radiation Effect on Pharmacokinetics of BIO 300, a Nanosuspension of Genistein, after Different Routes of Administration in Mice and Non-Human Primates

Radiation research, 2022-05, Vol.197 (5), p.447

2022

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The Radioprotectant, BIO 300, Protects the Lungs from Total-Body Irradiation Injury in C57L/J Mice

Radiation research, 2023-03, Vol.199 (3), p.294

2023

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Comparative proteomic analysis of serum from nonhuman primates administered BIO 300: a promising radiation countermeasure

Scientific reports, 2020-11, Vol.10 (1), p.19343, Article 19343

2020

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BIO 300: A Prophylactic Radiation Countermeasure for Acute Radiation Syndrome

Military medicine, 2024-08, Vol.189 (Supplement_3), p.390-398

2024

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Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum

Brain (London, England : 1878), 2012-04, Vol.135 (Pt 4), p.1197-1209

2012

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Safety, Pharmacokinetics, and Biomarkers of an Amorphous Solid Dispersion of Genistein, a Radioprotectant, in Healthy Volunteers

Clinical pharmacology in drug development, 2023-02, Vol.12 (2), p.190-201

2023

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DNA Nanoparticles: Detection of Long-Term Transgene Activity in Brain using Bioluminescence Imaging

Molecular imaging, 2011-09, Vol.10 (5), p.327-339

2011

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Recovery from Polyglutamine-Induced Neurodegeneration in Conditional SCA1 Transgenic Mice

The Journal of neuroscience, 2004-10, Vol.24 (40), p.8853-8861

2004

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The GSK3 β signaling cascade and neurodegenerative disease

Current Opinion in Neurobiology, 2002-06, Vol.12 (3), p.275-278

2002

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Modulating huntingtin half‐life alters polyglutamine‐dependent aggregate formation and cell toxicity

Journal of neurochemistry, 2004-05, Vol.89 (4), p.962-973

2004

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Interaction of Akt-Phosphorylated Ataxin-1 with 14-3-3 Mediates Neurodegeneration in Spinocerebellar Ataxia Type 1

Cell, 2003-05, Vol.113 (4), p.457-468

2003

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The radioprotectant nano-genistein enhances radiotherapy efficacy of lung tumors in mice

Translational lung cancer research, 2023-05, Vol.12 (5), p.999-1010

2023

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Pharmacokinetic and metabolomic studies with a BIO 300 Oral Powder formulation in nonhuman primates

Pharmacokinetic and Metabolomic Studies with BIO 300, a Nanosuspension of Genistein, in a Nonhuman Primate Model

BIO 300 Attenuates Whole Blood Transcriptome Changes in Mice Exposed to Total-Body Radiation

Targeted Metabolomics Identifies Pharmacodynamic Biomarkers for BIO 300 Mitigation of Radiation-Induced Lung Injury

Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome

Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease

Microbiome study in irradiated mice treated with BIO 300, a promising radiation countermeasure

Serine 776 of Ataxin-1 Is Critical for Polyglutamine-Induced Disease in SCA1 Transgenic Mice

BIO 300, a nanosuspension of genistein, mitigates pneumonitis/fibrosis following high‐dose radiation exposure in the C57L/J murine model

A novel oral formulation of BIO 300 confers prophylactic radioprotection from acute radiation syndrome in mice

A C57L/J Mouse Model of the Delayed Effects of Acute Radiation Exposure in the Context of Evolving Multi-Organ Dysfunction and Failure after Total-Body Irradiation with 2.5% Bone Marrow Sparing

BIO 300, a Nanosuspension of Genistein, Mitigates Radiation-Induced Erectile Dysfunction and Sensitizes Human Prostate Cancer Xenografts to Radiation Therapy

Multicenter Phase 1b/2a Clinical Trial of Radioprotectant BIO 300 Oral Suspension for Patients With Non-Small Cell Lung Cancer Receiving Concurrent Chemoradiotherapy

Interspecies Comparison and Radiation Effect on Pharmacokinetics of BIO 300, a Nanosuspension of Genistein, after Different Routes of Administration in Mice and Non-Human Primates

The Radioprotectant, BIO 300, Protects the Lungs from Total-Body Irradiation Injury in C57L/J Mice

Comparative proteomic analysis of serum from nonhuman primates administered BIO 300: a promising radiation countermeasure

BIO 300: A Prophylactic Radiation Countermeasure for Acute Radiation Syndrome

Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum

Safety, Pharmacokinetics, and Biomarkers of an Amorphous Solid Dispersion of Genistein, a Radioprotectant, in Healthy Volunteers

DNA Nanoparticles: Detection of Long-Term Transgene Activity in Brain using Bioluminescence Imaging

Recovery from Polyglutamine-Induced Neurodegeneration in Conditional SCA1 Transgenic Mice

The GSK3 β signaling cascade and neurodegenerative disease

Modulating huntingtin half‐life alters polyglutamine‐dependent aggregate formation and cell toxicity

Interaction of Akt-Phosphorylated Ataxin-1 with 14-3-3 Mediates Neurodegeneration in Spinocerebellar Ataxia Type 1

The radioprotectant nano-genistein enhances radiotherapy efficacy of lung tumors in mice

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