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Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (19), p.7745-7750

2011

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UDP-glucose dehydrogenase: structure and function of a potential drug target

Biochemical Society transactions, 2010-10, Vol.38 (5), p.1378-1385

2010

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The Molecular Mechanism of Nitrogen-Containing Bisphosphonates as Antiosteoporosis Drugs

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (20), p.7829-7834

2006

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Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase

The Journal of biological chemistry, 2011-07, Vol.286 (27), p.23877-23887

2011

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The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity

Biochemical journal, 2011-01, Vol.433 (2), p.303-311

2011

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A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase

ACS catalysis, 2019-04, Vol.9 (4), p.2962-2968

2019

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Reversible Sequestration of Active Site Cysteines in a 2Fe-2S-bridged Dimer Provides a Mechanism for Glutaredoxin 2 Regulation in Human Mitochondria

The Journal of biological chemistry, 2007-02, Vol.282 (5), p.3077-3082

2007

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Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Nature, 2007-07, Vol.448 (7149), p.87-91

2007

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Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

Journal of molecular biology, 2010-08, Vol.401 (2), p.211-222

2010

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The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography

Biochemical journal, 2005-01, Vol.385 (Pt 1), p.75-83

2005

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The Crystal Structure of Human Geranylgeranyl Pyrophosphate Synthase Reveals a Novel Hexameric Arrangement and Inhibitory Product Binding

The Journal of biological chemistry, 2006-08, Vol.281 (31), p.22004-22012

2006

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SALMON: Solvent Accessibility, Ligand binding, and Mapping of ligand Orientation by NMR Spectroscopy

Journal of medicinal chemistry, 2008-01, Vol.51 (1), p.1-3

2008

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Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease

The Journal of biological chemistry, 2005-12, Vol.280 (49), p.41101-41110

2005

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Aldehyde Dehydrogenase 7A1 (ALDH7A1) Is a Novel Enzyme Involved in Cellular Defense against Hyperosmotic Stress

The Journal of biological chemistry, 2010-06, Vol.285 (24), p.18452-18463

2010

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Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase

Biochemical and biophysical research communications, 2011-05, Vol.408 (4), p.553-558

2011

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The Structure of Apo and Holo Forms of Xylose Reductase, a Dimeric Aldo-Keto Reductase from Candida tenuis

Biochemistry (Easton), 2002-07, Vol.41 (28), p.8785-8795

2002

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The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative

Chemico-biological interactions, 2009-03, Vol.178 (1), p.94-98

2009

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Structure of xylose reductase bound to NAD+ and the basis for single and dual co-substrate specificity in family 2 aldo-keto reductases

Biochemical journal, 2003-07, Vol.373 (Pt 2), p.319-326

2003

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Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure–activity relationships

Chemico-biological interactions, 2015-06, Vol.234, p.114-125

2015

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Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy

Annals of the New York Academy of Sciences, 2007-11, Vol.1117 (1), p.209-257

2007

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Ribosomal oxygenases are structurally conserved from prokaryotes to humans

Nature (London), 2014-06, Vol.510 (7505), p.422-426

2014

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Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid

The Journal of biological chemistry, 2012-09, Vol.287 (37), p.31349-31358

2012

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Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use

Biochemistry (Easton), 2004-02, Vol.43 (4), p.879-889

2004

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The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants

Bone (New York, N.Y.), 2015-12, Vol.81, p.478-486

2015

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Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates

The Journal of biological chemistry, 2012-01, Vol.287 (3), p.2119-2129

2012

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Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

UDP-glucose dehydrogenase: structure and function of a potential drug target

The Molecular Mechanism of Nitrogen-Containing Bisphosphonates as Antiosteoporosis Drugs

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase

The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity

A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase

Reversible Sequestration of Active Site Cysteines in a 2Fe-2S-bridged Dimer Provides a Mechanism for Glutaredoxin 2 Regulation in Human Mitochondria

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography

The Crystal Structure of Human Geranylgeranyl Pyrophosphate Synthase Reveals a Novel Hexameric Arrangement and Inhibitory Product Binding

SALMON: Solvent Accessibility, Ligand binding, and Mapping of ligand Orientation by NMR Spectroscopy

Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease

Aldehyde Dehydrogenase 7A1 (ALDH7A1) Is a Novel Enzyme Involved in Cellular Defense against Hyperosmotic Stress

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase

The Structure of Apo and Holo Forms of Xylose Reductase, a Dimeric Aldo-Keto Reductase from Candida tenuis

The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative

Structure of xylose reductase bound to NAD+ and the basis for single and dual co-substrate specificity in family 2 aldo-keto reductases

Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure–activity relationships

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid

Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants

Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates

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