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Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring

Cancer chemotherapy and pharmacology, 2017-08, Vol.80 (2), p.343-353

2017

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Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models

The AAPS journal, 2011-06, Vol.13 (2), p.143-151

2011

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Importance of Shrinkage in Empirical Bayes Estimates for Diagnostics: Problems and Solutions

The AAPS journal, 2009-09, Vol.11 (3), p.558-569

2009

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Handling Data Below the Limit of Quantification in Mixed Effect Models

The AAPS journal, 2009-06, Vol.11 (2), p.371-380

2009

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Improving the estimation of parameter uncertainty distributions in nonlinear mixed effects models using sampling importance resampling

Journal of pharmacokinetics and pharmacodynamics, 2016-12, Vol.43 (6), p.583-596

2016

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An automated sampling importance resampling procedure for estimating parameter uncertainty

Journal of pharmacokinetics and pharmacodynamics, 2017-12, Vol.44 (6), p.509-520

2017

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Integrated Population Pharmacokinetic Analysis of Voriconazole in Children, Adolescents, and Adults

Antimicrobial Agents and Chemotherapy, 2012-06, Vol.56 (6), p.3032-3042

2012

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Population Pharmacokinetic Analysis of Voriconazole Plasma Concentration Data from Pediatric Studies

Antimicrobial Agents and Chemotherapy, 2009-03, Vol.53 (3), p.935-944

2009

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Conditional Weighted Residuals (CWRES) : A Model Diagnostic for the FOCE Method

Pharmaceutical research, 2007-12, Vol.24 (12), p.2187-2197

2007

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Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

Haematologica (Roma), 2020-05, Vol.105 (5), p.1443-1453

2020

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Comparison of Seven Non-Linear Mixed Effect Model-Based Approaches to Test for Treatment Effect

Pharmaceutics, 2023, Vol.15 (2), p.460

2023

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Exposure–safety analysis of QTc interval and transaminase levels following bedaquiline administration in patients with drug‐resistant tuberculosis

CPT: pharmacometrics and systems pharmacology, 2021-12, Vol.10 (12), p.1538-1549

2021

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Model-Based Estimates of the Effects of Efavirenz on Bedaquiline Pharmacokinetics and Suggested Dose Adjustments for Patients Coinfected with HIV and Tuberculosis

Antimicrobial Agents and Chemotherapy, 2013-06, Vol.57 (6), p.2780-2787

2013

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Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies

Journal of pharmacokinetics and pharmacodynamics, 2007-10, Vol.34 (5), p.711-726

2007

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A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6

PloS one, 2019-02, Vol.14 (2), p.e0211981-e0211981

2019

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Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies

Journal of antimicrobial chemotherapy, 2018-07, Vol.73 (7), p.1908-1916

2018

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Population pharmacokinetics of edoxaban and its main metabolite in a dedicated renal impairment study

Journal of clinical pharmacology, 2015-11, Vol.55 (11), p.1268-1279

2015

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Assessment of ibrutinib scheduling on leukocyte, lymph node size and blood pressure dynamics in chronic lymphocytic leukemia through pharmacokinetic-pharmacodynamic models

CPT: pharmacometrics and systems pharmacology, 2023-09, Vol.12 (9), p.1305-1318

2023

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Prediction of exposure-driven myelotoxicity of continuous infusion 5-fluorouracil by a semi-physiological pharmacokinetic–pharmacodynamic model in gastrointestinal cancer patients

Cancer chemotherapy and pharmacology, 2020-04, Vol.85 (4), p.711-722

2020

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A diagnostic tool for population models using non-compartmental analysis: The ncappc package for R

Computer methods and programs in biomedicine, 2016-04, Vol.127, p.83-93

2016

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Optimization of blood pressure measurement practices for pharmacodynamic analyses of tyrosine‐kinase inhibitors

Clinical and translational science, 2023-01, Vol.16 (1), p.73-84

2023

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An introduction to the full random effects model

CPT: pharmacometrics and systems pharmacology, 2022-02, Vol.11 (2), p.149-160

2022

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Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item‐score models

CPT: pharmacometrics and systems pharmacology, 2021-04, Vol.10 (4), p.309-317

2021

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Item performance of the scale for the assessment and rating of ataxia in rare and ultra‐rare genetic ataxias

CPT: pharmacometrics and systems pharmacology, 2024-08, Vol.13 (8), p.1327-1340

2024

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Model of Chemotherapy-Induced Myelosuppression With Parameter Consistency Across Drugs

Journal of clinical oncology, 2002-12, Vol.20 (24), p.4713-4721

2002

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Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring

Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models

Importance of Shrinkage in Empirical Bayes Estimates for Diagnostics: Problems and Solutions

Handling Data Below the Limit of Quantification in Mixed Effect Models

Improving the estimation of parameter uncertainty distributions in nonlinear mixed effects models using sampling importance resampling

An automated sampling importance resampling procedure for estimating parameter uncertainty

Integrated Population Pharmacokinetic Analysis of Voriconazole in Children, Adolescents, and Adults

Population Pharmacokinetic Analysis of Voriconazole Plasma Concentration Data from Pediatric Studies

Conditional Weighted Residuals (CWRES) : A Model Diagnostic for the FOCE Method

Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

Comparison of Seven Non-Linear Mixed Effect Model-Based Approaches to Test for Treatment Effect

Exposure–safety analysis of QTc interval and transaminase levels following bedaquiline administration in patients with drug‐resistant tuberculosis

Model-Based Estimates of the Effects of Efavirenz on Bedaquiline Pharmacokinetics and Suggested Dose Adjustments for Patients Coinfected with HIV and Tuberculosis

Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies

A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6

Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies

Population pharmacokinetics of edoxaban and its main metabolite in a dedicated renal impairment study

Assessment of ibrutinib scheduling on leukocyte, lymph node size and blood pressure dynamics in chronic lymphocytic leukemia through pharmacokinetic-pharmacodynamic models

Prediction of exposure-driven myelotoxicity of continuous infusion 5-fluorouracil by a semi-physiological pharmacokinetic–pharmacodynamic model in gastrointestinal cancer patients

A diagnostic tool for population models using non-compartmental analysis: The ncappc package for R

Optimization of blood pressure measurement practices for pharmacodynamic analyses of tyrosine‐kinase inhibitors

An introduction to the full random effects model

Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item‐score models

Item performance of the scale for the assessment and rating of ataxia in rare and ultra‐rare genetic ataxias

Model of Chemotherapy-Induced Myelosuppression With Parameter Consistency Across Drugs

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