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Costly Genes

PLoS genetics, 2020-08, Vol.16 (8), p.e1008889-e1008889

2020

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Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia

Nature (London), 2010-04, Vol.464 (7289), p.763-767

2010

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De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia

Neuron (Cambridge, Mass.), 2016-03, Vol.89 (5), p.940-947

2016

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De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia

Nature genetics, 2012-12, Vol.44 (12), p.1365-1369

2012

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Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

Nature biotechnology, 2017-02, Vol.35 (2), p.154-163

2017

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Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate Susceptibility Gene

Neuron (Cambridge, Mass.), 2014-05, Vol.82 (4), p.773-780

2014

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Derepression of a Neuronal Inhibitor due to miRNA Dysregulation in a Schizophrenia-Related Microdeletion

Cell, 2013-01, Vol.152 (1-2), p.262-275

2013

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Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia

Neuron (Cambridge, Mass.), 2015-05, Vol.86 (3), p.680-695

2015

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Diverse types of genetic variation converge on functional gene networks involved in schizophrenia

Nature neuroscience, 2012-12, Vol.15 (12), p.1723-1728

2012

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The Genetic Architecture of Schizophrenia: New Mutations and Emerging Paradigms

Annual review of medicine, 2012-01, Vol.63 (1), p.63-80

2012

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MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction

Neurobiology of disease, 2012-05, Vol.46 (2), p.291-301

2012

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Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (11), p.4447-4452

2011

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mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (19), p.7076-7081

2008

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Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice

Journal of neurochemistry, 2010-09, Vol.114 (6), p.1745-1755

2010

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Disc1 Is Mutated in the 129S6/SvEv Strain and Modulates Working Memory in Mice

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (10), p.3693-3697

2006

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Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism

Proceedings of the National Academy of Sciences - PNAS, 2014-01, Vol.111 (1), p.343-348

2014

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The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion

The Journal of neuroscience, 2013-09, Vol.33 (37), p.14825-14839

2013

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Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (49), p.E1349-E1358

2011

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The BDNF Val66Met variant affects gene expression through miR-146b

Neurobiology of disease, 2015-05, Vol.77, p.228-237

2015

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Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans

Proceedings of the National Academy of Sciences - PNAS, 2009-09, Vol.106 (39), p.16746-16751

2009

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Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice

Nature neuroscience, 2005-11, Vol.8 (11), p.1586-1594

2005

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Evidence for Association of Schizophrenia with Genetic Variation in the 8p21.3 Gene, PPP3CC, Encoding the Calcineurin Gamma Subunit

Proceedings of the National Academy of Sciences - PNAS, 2003-07, Vol.100 (15), p.8993-8998

2003

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Catechol-O-methyltransferase-Deficient Mice Exhibit Sexually Dimorphic Changes in Catecholamine Levels and Behavior

Proceedings of the National Academy of Sciences - PNAS, 1998-08, Vol.95 (17), p.9991-9996

1998

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Akt1 Deficiency Affects Neuronal Morphology and Predisposes to Abnormalities in Prefrontal Cortex Functioning

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (45), p.16906-16911

2006

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Evidence for altered hippocampal function in a mouse model of the human 22q11.2 microdeletion

Molecular and cellular neuroscience, 2011-08, Vol.47 (4), p.293-305

2011

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Costly Genes

Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia

De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia

De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate Susceptibility Gene

Derepression of a Neuronal Inhibitor due to miRNA Dysregulation in a Schizophrenia-Related Microdeletion

Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia

Diverse types of genetic variation converge on functional gene networks involved in schizophrenia

The Genetic Architecture of Schizophrenia: New Mutations and Emerging Paradigms

MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction

Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex

mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice

Disc1 Is Mutated in the 129S6/SvEv Strain and Modulates Working Memory in Mice

Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism

The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion

Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice

The BDNF Val66Met variant affects gene expression through miR-146b

Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans

Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice

Evidence for Association of Schizophrenia with Genetic Variation in the 8p21.3 Gene, PPP3CC, Encoding the Calcineurin Gamma Subunit

Catechol-O-methyltransferase-Deficient Mice Exhibit Sexually Dimorphic Changes in Catecholamine Levels and Behavior

Akt1 Deficiency Affects Neuronal Morphology and Predisposes to Abnormalities in Prefrontal Cortex Functioning

Evidence for altered hippocampal function in a mouse model of the human 22q11.2 microdeletion

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