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Development of an Efficient Therapeutic Agent for Alzheimer's Disease: Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter

Chemical and Pharmaceutical Bulletin, 2010/03/01, Vol.58(3), pp.273-287

2010

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A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease

Bioorganic & medicinal chemistry, 2003-10, Vol.11 (20), p.4389-4415

2003

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Pharmacological Characterization of RS-1259, an Orally Active Dual Inhibitor of Acetylcholinesterase and Serotonin Transporter, in Rodents: Possible Treatment of Alzheimer’s Disease

Journal of Pharmacological Sciences, 2003, Vol.93(1), pp.95-105

2003

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Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter Targeting Potential Agents for Alzheimer's Disease

Organic letters, 2002-10, Vol.4 (20), p.3359-3362

2002

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Design, synthesis and structure–Activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease

Bioorganic & medicinal chemistry, 2003-05, Vol.11 (9), p.1935-1955

2003

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Disruption of trace conditioning of the nictitating membrane response in rabbits by central cholinergic blockade

Psychopharmacologia, 1997-05, Vol.131 (2), p.161-166

1997

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Age-related working memory deficits in the allocentric place discrimination task: possible involvement in cholinergic dysfunction

Neurobiology of aging, 1999-11, Vol.20 (6), p.629-636

1999

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The Allocentric Place Discrimination Task Is Selectively and Highly Dependent on the Central Muscarinic System in Rats

Pharmacology, biochemistry and behavior, 2000, Vol.65 (1), p.131-139

2000

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Development of an Efficient Therapeutic Agent for Alzheimer's Disease

Chemical & pharmaceutical bulletin, 2010-03, Vol.58 (3), p.273

2010

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Pharmacological Characterization of RS-1259, an Orally Active Dual Inhibitor of Acetylcholinesterase and Serotonin Transporter, in Rodents: Possible Treatment of Alzheimer’s Disease

Journal of pharmacological sciences, 2003, Vol.93 (4), p.95-105

2003

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Simultaneous evaluation of spatial working memory and motivation by the allocentric place discrimination task in the water maze in rats

Journal of Veterinary Medical Science, 1999/06/25, Vol.61(6), pp.673-681

1999

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NMDA Receptors in the Spinal Cord Exert Excitatory Influences on Spinal Motor Output in Rats

The Japanese Journal of Pharmacology, 2001, Vol.87(4), pp.343-346

2001

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Age-related working memory deficits in the allocentric place discrimination task: possible involvement in cholinergic dysfunction

Neurobiology of aging, 2000-01, Vol.20 (6), p.629-636

2000

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Spatial Working Memory Is Independent of Hippocampal CA1 Long-Term Potentiation in Rats

Behavioral neuroscience, 2000-08, Vol.114 (4), p.700-706

2000

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Preferential enhancement of inhibitory synaptic transmission by CS-722 in the ventral horn neurons of neonatal rats

Japanese Journal of Pharmacology, 1997, Vol.73 (suppl.1), p.212-212

1997

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Paired pulse facilitation of GABAergic IPSCs in ventral horn neurons in neonatal rat spinal cord

Brain research, 1996-04, Vol.716 (1), p.101-106

1996

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Effects of nicotine on MPTP-induced parkinsonism in common marmosets

Japanese Journal of Pharmacology, 2000, Vol.82 (suppl.1), p.73-73

2000

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Preferential enhancement of inhibitory synaptic transmission by CS-722 in the ventral horn neurons of neonatal rat spinal cord

European journal of pharmacology, 1996-10, Vol.313 (3), p.187-189

1996

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ChemInform Abstract: Development of an Efficient Therapeutic Agent for Alzheimer′s Disease: Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter

ChemInform, 2010-08, Vol.41 (31), p.no-no

2010

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Effects on blood viscosity of RS-8359 and its optically-active isomers

Japanese Journal of Pharmacology, 1998, Vol.76 (suppl.1), p.227-227

1998

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Conformational Analysis and Docking Study of Potent Acetylcholinesterase Inhibitors Having a Benzylamine Moiety

Chem-Bio Informatics Journal, 2003, Vol.3(2), pp.46-57

2003

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Central activation by CS-932, a functionally relative M1 agonist

Neuroscience research, 1998, Vol.31, p.S361-S361

1998

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Sites of Action of CS-722, a Newly Synthesized Centrally Acting Muscle Relaxant

The Japanese Journal of Pharmacology, 1993, Vol.63(3), pp.385-389

1993

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Simultaneous evaluation of drug effects on both the spinal cord and the descending pathways in rats

Japanese Journal of Pharmacology, 1986, Vol.40 (suppl), p.283-283

1986

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DETERIORATION OF SPINAL REFLEX IN BEAGLES ORALLY INGESTING CLIOQUINOL

The Journal of Toxicological Sciences, 1982/02/25, Vol.7(1), pp.1-12

1982

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Development of an Efficient Therapeutic Agent for Alzheimer's Disease: Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter

A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease

Pharmacological Characterization of RS-1259, an Orally Active Dual Inhibitor of Acetylcholinesterase and Serotonin Transporter, in Rodents: Possible Treatment of Alzheimer’s Disease

Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter Targeting Potential Agents for Alzheimer's Disease

Design, synthesis and structure–Activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease

Disruption of trace conditioning of the nictitating membrane response in rabbits by central cholinergic blockade

Age-related working memory deficits in the allocentric place discrimination task: possible involvement in cholinergic dysfunction

The Allocentric Place Discrimination Task Is Selectively and Highly Dependent on the Central Muscarinic System in Rats

Development of an Efficient Therapeutic Agent for Alzheimer's Disease

Pharmacological Characterization of RS-1259, an Orally Active Dual Inhibitor of Acetylcholinesterase and Serotonin Transporter, in Rodents: Possible Treatment of Alzheimer’s Disease

Simultaneous evaluation of spatial working memory and motivation by the allocentric place discrimination task in the water maze in rats

NMDA Receptors in the Spinal Cord Exert Excitatory Influences on Spinal Motor Output in Rats

Age-related working memory deficits in the allocentric place discrimination task: possible involvement in cholinergic dysfunction

Spatial Working Memory Is Independent of Hippocampal CA1 Long-Term Potentiation in Rats

Preferential enhancement of inhibitory synaptic transmission by CS-722 in the ventral horn neurons of neonatal rats

Paired pulse facilitation of GABAergic IPSCs in ventral horn neurons in neonatal rat spinal cord

Effects of nicotine on MPTP-induced parkinsonism in common marmosets

Preferential enhancement of inhibitory synaptic transmission by CS-722 in the ventral horn neurons of neonatal rat spinal cord

ChemInform Abstract: Development of an Efficient Therapeutic Agent for Alzheimer′s Disease: Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter

Effects on blood viscosity of RS-8359 and its optically-active isomers

Conformational Analysis and Docking Study of Potent Acetylcholinesterase Inhibitors Having a Benzylamine Moiety

Central activation by CS-932, a functionally relative M1 agonist

Sites of Action of CS-722, a Newly Synthesized Centrally Acting Muscle Relaxant

Simultaneous evaluation of drug effects on both the spinal cord and the descending pathways in rats

DETERIORATION OF SPINAL REFLEX IN BEAGLES ORALLY INGESTING CLIOQUINOL

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