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Identification of a novel glucosylsulfate conjugate as a metabolite of 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501, beta-lapachone) in mammals

Drug metabolism and disposition, 2008-04, Vol.36 (4), p.753

2008

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Identification of the in vitro metabolites of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (ARQ 501; beta-lapachone) in whole blood

Drug metabolism and disposition, 2008-04, Vol.36 (4), p.641

2008

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Synthetic methods for the preparation of ARQ 501 (β-Lapachone) human blood metabolites

Bioorganic & medicinal chemistry, 2008-05, Vol.16 (10), p.5635-5643

2008

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Discovery of a Novel Mode of Protein Kinase Inhibition Characterized by the Mechanism of Inhibition of Human Mesenchymal-epithelial Transition Factor (c-Met) Protein Autophosphorylation by ARQ 197

The Journal of biological chemistry, 2011-06, Vol.286 (23), p.20666-20676

2011

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D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

Molecular cancer therapeutics, 2007-01, Vol.6 (1), p.193-202

2007

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A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor

The Journal of biological chemistry, 2011-06, Vol.286 (23), p.20677-20687

2011

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In vitro metabolism of β-lapachone (ARQ 501) in mammalian hepatocytes and cultured human cells

Rapid communications in mass spectrometry, 2009-01, Vol.23 (1), p.12-22

2009

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A 1V, Micropower System-on-Chip for Vital-Sign Monitoring in Wireless Body Sensor Networks

2008 IEEE International Solid-State Circuits Conference - Digest of Technical Papers, 2008, p.138-602

2008

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Enhanced Econazole Penetration into Human Nail by 2-n-Nonyl-1,3-dioxolane

Journal of pharmaceutical sciences, 2003-01, Vol.92 (1), p.142-148

2003

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Intracisternal osteogenic protein-1 enhances functional recovery following focal stroke

Neuroreport, 1998-05, Vol.9 (7), p.1441-1445

1998

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Phase I trial of piroxicam in 62 dogs bearing naturally occurring tumors

Cancer chemotherapy and pharmacology, 1992-01, Vol.29 (3), p.214-218

1992

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Spontaneous metastasis of PC-3 cells in athymic mice after implantation in orthotopic or ectopic microenvironments

The Prostate, 1995-05, Vol.26 (5), p.227-234

1995

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Abstract 4501: Development and biological annotation of a novel RAF inhibitor amenable for clinical evaluation against BRAF (V600E)-harboring human tumors

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.4501-4501

2010

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Piroxicam therapy in 34 dogs with transitional cell carcinoma of the urinary bladder

Journal of veterinary internal medicine, 1994-07, Vol.8 (4), p.273-278

1994

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Abstract 5376: Potentiation of the anti-proliferative and cytotoxic activity of ARQ 197 & gemcitabine with a pulsatile exposure regimen

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.5376-5376

2011

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Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome

Chinese medical journal, 2005-09, Vol.118 (17), p.1413-1421

2005

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The effects of chronic ethanol consumption on cardiac function in rats

Canadian journal of physiology and pharmacology, 1982-06, Vol.60 (6), p.777

1982

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Evaluation of in vitro cytotoxicity of nonsteroidal anti-inflammatory drugs against canine tumor cells

American journal of veterinary research, 1995-06, Vol.56 (6), p.801

1995

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Synergism between dipyridamole and cisplatin in human ovarian carcinoma cells in vitro

Cancer research (Chicago, Ill.), 1992-07, Vol.52 (13), p.3566-3571

1992

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Ultrastructure and cytochemical staining characteristics of canine natural killer cells

The Anatomical record, 1995-12, Vol.243 (4), p.509-515

1995

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Epidermal growth factor induces terminal differentiation in human epidermoid carcinoma cells

Journal of cellular physiology, 1993-09, Vol.156 (3), p.515-521

1993

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The readers' NIH

Science (American Association for the Advancement of Science), 1992-10, Vol.258 (5082), p.530-530

Chan, T C

1992

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Mechanism of synergy between N-phosphonacetyl-L-aspartate and dipyridamole in a human ovarian carcinoma cell line

Cancer research (Chicago, Ill.), 1985-08, Vol.45 (8), p.3598-3604

1985

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Dipyridamole enhancement of etoposide sensitivity

Cancer research (Chicago, Ill.), 1989-08, Vol.49 (15), p.4147-4153

1989

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Discovery and Optimization of a Series of 3-(3-Phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: Orally Bioavailable, Selective, and Potent ATP-Independent Akt Inhibitors

Identification of a novel glucosylsulfate conjugate as a metabolite of 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501, beta-lapachone) in mammals

Identification of the in vitro metabolites of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (ARQ 501; beta-lapachone) in whole blood

Synthetic methods for the preparation of ARQ 501 (β-Lapachone) human blood metabolites

Discovery of a Novel Mode of Protein Kinase Inhibition Characterized by the Mechanism of Inhibition of Human Mesenchymal-epithelial Transition Factor (c-Met) Protein Autophosphorylation by ARQ 197

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor

In vitro metabolism of β-lapachone (ARQ 501) in mammalian hepatocytes and cultured human cells

A 1V, Micropower System-on-Chip for Vital-Sign Monitoring in Wireless Body Sensor Networks

Enhanced Econazole Penetration into Human Nail by 2-n-Nonyl-1,3-dioxolane

Intracisternal osteogenic protein-1 enhances functional recovery following focal stroke

Phase I trial of piroxicam in 62 dogs bearing naturally occurring tumors

Spontaneous metastasis of PC-3 cells in athymic mice after implantation in orthotopic or ectopic microenvironments

Abstract 4501: Development and biological annotation of a novel RAF inhibitor amenable for clinical evaluation against BRAF (V600E)-harboring human tumors

Piroxicam therapy in 34 dogs with transitional cell carcinoma of the urinary bladder

Abstract 5376: Potentiation of the anti-proliferative and cytotoxic activity of ARQ 197 & gemcitabine with a pulsatile exposure regimen

Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome

The effects of chronic ethanol consumption on cardiac function in rats

Evaluation of in vitro cytotoxicity of nonsteroidal anti-inflammatory drugs against canine tumor cells

Synergism between dipyridamole and cisplatin in human ovarian carcinoma cells in vitro

Ultrastructure and cytochemical staining characteristics of canine natural killer cells

Epidermal growth factor induces terminal differentiation in human epidermoid carcinoma cells

The readers' NIH

Mechanism of synergy between N-phosphonacetyl-L-aspartate and dipyridamole in a human ovarian carcinoma cell line

Dipyridamole enhancement of etoposide sensitivity

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