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Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo

Journal of medicinal chemistry, 2019-11, Vol.62 (22), p.10321-10341

2019

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modular toolkit to inhibit proline-rich motif–mediated protein–protein interactions

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (16), p.5011-5016

2015

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Recognition of Proline-Rich Motifs by Protein-Protein-Interaction Domains

Angewandte Chemie (International ed.), 2005-05, Vol.44 (19), p.2852-2869

2005

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Ena/VASP proteins at the crossroads of actin nucleation pathways in dendritic cell migration

Frontiers in cell and developmental biology, 2022-10, Vol.10, p.1008898-1008898

2022

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Intramolecular bridges formed by photoswitchable click amino acids

Beilstein journal of organic chemistry, 2012-06, Vol.8 (1), p.884-889

2012

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Molecular evolution of a peptide GPCR ligand driven by artificial neural networks

PloS one, 2012-05, Vol.7 (5), p.e36948-e36948

2012

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Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling

PloS one, 2011-02, Vol.6 (2), p.e16811

2011

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Limits of conservation agriculture to overcome low crop yields in sub-Saharan Africa

Nature food, 2020-07, Vol.1 (7), p.447-454

2020

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Characterization of structural features controlling the receptiveness of empty class II MHC molecules

PloS one, 2011-04, Vol.6 (4), p.e18662

2011

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A single glycine-alanine exchange directs ligand specificity of the elephant progestin receptor

PloS one, 2012-11, Vol.7 (11), p.e50350

2012

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Anchor side chains of short peptide fragments trigger ligand-exchange of class II MHC molecules

PloS one, 2008-03, Vol.3 (3), p.e1814-e1814

2008

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Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

Proceedings of the National Academy of Sciences - PNAS, 2020-11, Vol.117 (47), p.29684-29690

2020

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Design and synthesis of a tetracyclic tripeptide mimetic frozen in a polyproline type II (PP2) helix conformation

Organic & biomolecular chemistry, 2022-12, Vol.2 (47), p.9368-9377

2022

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Mutational Analysis of the Antagonist-binding Site of the Histamine H1 Receptor

The Journal of biological chemistry, 1999-10, Vol.274 (42), p.29994-30000

1999

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Small Organic Compounds Enhance Antigen Loading of Class II Major Histocompatibility Complex Proteins by Targeting the Polymorphic P1 Pocket

The Journal of biological chemistry, 2006-12, Vol.281 (50), p.38535-38542

2006

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Residues within Transmembrane Helices 2 and 5 of the Human Gonadotropin-Releasing Hormone Receptor Contribute to Agonist and Antagonist Binding

Molecular endocrinology (Baltimore, Md.), 2000-07, Vol.14 (7), p.1099-1115

2000

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Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

Nature structural & molecular biology, 2010-09, Vol.17 (9), p.1037-1042

2010

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The contributions of specific amino acid side chains to signal intensities of peptides in matrix-assisted laser desorption/ionization mass spectrometry

Rapid communications in mass spectrometry, 2004-01, Vol.18 (8), p.863-868

2004

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Temporal variability of selected soil microbiological and biochemical indicators under different soil quality conditions in south-western Nigeria

Biology and fertility of soils, 2002-05, Vol.35 (3), p.155-167

2002

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Efficient Solution Phase Synthesis of PPII Helix Mimicking Ena/VASP EVH1 Inhibitors from Proline‐Derived Modules (ProMs)

European journal of organic chemistry, 2023-10, Vol.26 (39)

2023

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C‐Terminal Decarboxylation of Proline‐Derived Building Blocks for Protein‐Binding Peptides

Chemistry : a European journal, 2024-07, Vol.30 (42), p.e202401678-n/a

2024

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Design and Synthesis of Building Blocks for PPII‐Helix Secondary‐Structure Mimetics: A Stereoselective Entry to 4‐Substituted 5‐Vinylprolines

European journal of organic chemistry, 2018-01, Vol.2018 (4), p.455-460

2018

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Histaprodifens: Synthesis, Pharmacological in Vitro Evaluation, and Molecular Modeling of a New Class of Highly Active and Selective Histamine H1-Receptor Agonists

Journal of medicinal chemistry, 2000-03, Vol.43 (6), p.1071-1084

2000

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Soil microbiological parameters as indicators of soil quality under improved fallow management systems in south-western Nigeria

Plant and soil, 1998-05, Vol.202 (1), p.97-107

1998

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Triple‐Helix‐Stabilizing Effects in Collagen Model Peptides Containing PPII‐Helix‐Preorganized Diproline Modules

Angewandte Chemie International Edition, 2020-03, Vol.59 (14), p.5747-5755

International ed. in English, 2020

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Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo

modular toolkit to inhibit proline-rich motif–mediated protein–protein interactions

Recognition of Proline-Rich Motifs by Protein-Protein-Interaction Domains

Ena/VASP proteins at the crossroads of actin nucleation pathways in dendritic cell migration

Intramolecular bridges formed by photoswitchable click amino acids

Molecular evolution of a peptide GPCR ligand driven by artificial neural networks

Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling

Limits of conservation agriculture to overcome low crop yields in sub-Saharan Africa

Characterization of structural features controlling the receptiveness of empty class II MHC molecules

A single glycine-alanine exchange directs ligand specificity of the elephant progestin receptor

Anchor side chains of short peptide fragments trigger ligand-exchange of class II MHC molecules

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

Design and synthesis of a tetracyclic tripeptide mimetic frozen in a polyproline type II (PP2) helix conformation

Mutational Analysis of the Antagonist-binding Site of the Histamine H1 Receptor

Small Organic Compounds Enhance Antigen Loading of Class II Major Histocompatibility Complex Proteins by Targeting the Polymorphic P1 Pocket

Residues within Transmembrane Helices 2 and 5 of the Human Gonadotropin-Releasing Hormone Receptor Contribute to Agonist and Antagonist Binding

Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

The contributions of specific amino acid side chains to signal intensities of peptides in matrix-assisted laser desorption/ionization mass spectrometry

Temporal variability of selected soil microbiological and biochemical indicators under different soil quality conditions in south-western Nigeria

Efficient Solution Phase Synthesis of PPII Helix Mimicking Ena/VASP EVH1 Inhibitors from Proline‐Derived Modules (ProMs)

C‐Terminal Decarboxylation of Proline‐Derived Building Blocks for Protein‐Binding Peptides

Design and Synthesis of Building Blocks for PPII‐Helix Secondary‐Structure Mimetics: A Stereoselective Entry to 4‐Substituted 5‐Vinylprolines

Histaprodifens: Synthesis, Pharmacological in Vitro Evaluation, and Molecular Modeling of a New Class of Highly Active and Selective Histamine H1-Receptor Agonists

Soil microbiological parameters as indicators of soil quality under improved fallow management systems in south-western Nigeria

Triple‐Helix‐Stabilizing Effects in Collagen Model Peptides Containing PPII‐Helix‐Preorganized Diproline Modules

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