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Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro–In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2795-2804

2017

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Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance

Drug metabolism and disposition, 2018-07, Vol.46 (7), p.989-1000

2018

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Relative contributions of cytochrome CYP3A4 versus CYP3A5 for CYP3A-cleared drugs assessed in vitro using a CYP3A4-selective inactivator (CYP3cide)

Drug metabolism and disposition, 2014-07, Vol.42 (7), p.1163

2014

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Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides

Drug metabolism and disposition, 2017-07, Vol.45 (7), p.721-733

2017

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The effect of fermented wheat germ extract on production parameters and immune status of growing pigs

Journal of Animal and Feed Sciences, 2011-01, Vol.20 (1), p.36-46

2011

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Novel Method to Predict In Vivo Liver-to-Plasma K puu for OATP Substrates Using Suspension Hepatocytes

Drug metabolism and disposition, 2017-05, Vol.45 (5), p.576-580

2017

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Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Journal of medicinal chemistry, 2012-02, Vol.55 (3), p.1318-1333

2012

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Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey

Drug metabolism and disposition, 2018-08, Vol.46 (8), p.1179-1189

2018

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Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey

The Journal of pharmacology and experimental therapeutics, 2021-04, Vol.377 (1), p.169

2021

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Testing the efficacy of fermented wheat germ extract against Mycoplasma gallisepticum infection of chickens

Poultry science, 2004-11, Vol.83 (11), p.1844-1848

2004

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Unbound tissue exposure (Kpuu) of oatps substrates in the cynomolgus monkey

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S105-S105

2017

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The effect of syndepositional deformation within the Upper Permian Capitan Platform on the speleogenesis and geomorphology of the Guadalupe Mountains, New Mexico, USA

Geomorphology (Amsterdam, Netherlands), 2006-08, Vol.78 (3), p.279-308

2006

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In vitro to in vivo translation of OATP-mediated drug–drug interactions in cynomolgus monkey

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S16-S16

2018

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Relationship between S-methylmethionine treatment and the activities of antioxidant enzymes in maize ( Zea mays L.) leaves at chilling temperatures

Acta agronomica Hungarica, 2009-12, Vol.57 (4), p.461-469

2009

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Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

ACS medicinal chemistry letters, 2014-05, Vol.5 (5), p.474-479

2014

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Role of S-methylmethionine in the plant metabolism

Acta agronomica Hungarica, 2007-12, Vol.55 (4), p.491-508

2007

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Analysis of Volatile Organic Compounds in Mainstream Cigarette Smoke

Environmental science & technology, 2007-02, Vol.41 (4), p.1297-1302

2007

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Differential subsidence driving the formation of mounded stratigraphy in deep-water sediments; Palaeocene, central North Sea

Marine and petroleum geology, 2007-12, Vol.24 (10), p.632-652

KOSA, Eduard

2007

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Effects of pinealectomy on glucagon responsiveness to hypoglycaemia induced by insulin injections in fed rats

Experimental physiology, 2001-09, Vol.86 (5), p.617-620

2001

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Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione- S-transferases and in vivo quantitation of a glutathione conjugate in rats

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (21), p.6262-6267

2010

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Effect of increased UV-B radiation on the anthocyanin content of maize ( Zea mays L.) leaves

Acta agronomica Hungarica, 2007-03, Vol.55 (1), p.7-17

2007

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Growth of syndepositional faults in carbonate strata: Upper Permian Capitan platform, New Mexico, USA

Journal of structural geology, 2005-06, Vol.27 (6), p.1069-1094

2005

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Experiences with fetal phonocardiographic telemonitoring and future possibilities

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2008, Vol.2008, p.5859-5862

2008

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IEEE_Xplore

Schilddrüse 1993: Therapie der Hyperthyreose. 11. Konferenz über die menschliche Schilddrüse, Heidelberg

D. Reinwein, B. Weinheimer / D. Reinwein, B. Weinheimer

2020

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Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro–In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance

Relative contributions of cytochrome CYP3A4 versus CYP3A5 for CYP3A-cleared drugs assessed in vitro using a CYP3A4-selective inactivator (CYP3cide)

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides

The effect of fermented wheat germ extract on production parameters and immune status of growing pigs

Novel Method to Predict In Vivo Liver-to-Plasma K puu for OATP Substrates Using Suspension Hepatocytes

Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey

Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)

Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey

Testing the efficacy of fermented wheat germ extract against Mycoplasma gallisepticum infection of chickens

Unbound tissue exposure (Kpuu) of oatps substrates in the cynomolgus monkey

The effect of syndepositional deformation within the Upper Permian Capitan Platform on the speleogenesis and geomorphology of the Guadalupe Mountains, New Mexico, USA

In vitro to in vivo translation of OATP-mediated drug–drug interactions in cynomolgus monkey

Relationship between S-methylmethionine treatment and the activities of antioxidant enzymes in maize ( Zea mays L.) leaves at chilling temperatures

Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

Role of S-methylmethionine in the plant metabolism

Analysis of Volatile Organic Compounds in Mainstream Cigarette Smoke

Differential subsidence driving the formation of mounded stratigraphy in deep-water sediments; Palaeocene, central North Sea

Effects of pinealectomy on glucagon responsiveness to hypoglycaemia induced by insulin injections in fed rats

Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione- S-transferases and in vivo quantitation of a glutathione conjugate in rats

Effect of increased UV-B radiation on the anthocyanin content of maize ( Zea mays L.) leaves

Growth of syndepositional faults in carbonate strata: Upper Permian Capitan platform, New Mexico, USA

Experiences with fetal phonocardiographic telemonitoring and future possibilities

Schilddrüse 1993: Therapie der Hyperthyreose. 11. Konferenz über die menschliche Schilddrüse, Heidelberg

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