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In vitro metabolism of haloperidol and sila-haloperidol: new metabolic pathways resulting from carbon/silicon exchange

Drug metabolism and disposition, 2010-01, Vol.38 (1), p.73-83

2010

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Engineering highly functional thermostable proteins using ancestral sequence reconstruction

Nature catalysis, 2018-11, Vol.1 (11), p.878-888

2018

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Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design

PloS one, 2015-01, Vol.10 (1), p.e0113705-e0113705

2015

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Novel metabolites of amodiaquine formed by CYP1A1 and CYP1B1: structure elucidation using electrochemistry, mass spectrometry, and NMR

Drug metabolism and disposition, 2009-03, Vol.37 (3), p.571-579

2009

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Development and Evaluation of an Electrochemical Method for Studying Reactive Phase-I Metabolites: Correlation to in Vitro Drug Metabolism

Chemical research in toxicology, 2007-05, Vol.20 (5), p.821-831

2007

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Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions

Rapid communications in mass spectrometry, 2003-01, Vol.17 (8), p.800-810

2003

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Early human in vivo pharmacokinetic predictions in drug discovery

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S43-S43

2018

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The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7302-7305

2012

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Electrochemical generation of reactive drug metabolites – Applications in drug discovery and development

Toxicology letters, 2014-09, Vol.229, p.S250-S250

Jurva, Ulrik

2014

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Electrochemical Oxidation of Troglitazone: Identification and Characterization of the Major Reactive Metabolite in Liver Microsomes

Chemical research in toxicology, 2008-10, Vol.21 (10), p.2035-2041

2008

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In vitro mimicry of metabolic oxidation reactions by electrochemistry/mass spectrometry

Rapid communications in mass spectrometry, 2000-03, Vol.14 (6), p.529-533

2000

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Mimicry of phase I drug metabolism - novel methods for metabolite characterization and synthesis

Rapid communications in mass spectrometry, 2007-01, Vol.21 (14), p.2323-2331

2007

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Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S‑Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes

Chemical research in toxicology, 2015-05, Vol.28 (5), p.886-896

2015

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Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents

Bioorganic & medicinal chemistry letters, 2019-05, Vol.29 (10), p.1241-1245

2019

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Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction

Journal of medicinal chemistry, 2022-09, Vol.65 (17), p.11485-11496

2022

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Use of Electrochemical Oxidation and Model Peptides To Study Nucleophilic Biological Targets of Reactive Metabolites: The Case of Rimonabant

Chemical research in toxicology, 2014-10, Vol.27 (10), p.1808-1820

2014

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Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans

Drug metabolism and disposition, 2023-04, Vol.51 (4), p.464-479

2023

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Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates

Molecular biology and evolution, 2022-06, Vol.39 (6)

2022

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Correction to “Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction”

Journal of medicinal chemistry, 2022-10, Vol.65 (19), p.13482-13482

2022

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Biocatalysis using Thermostable Cytochrome P450 Enzymes in Bacterial Membranes - Comparison of Metabolic Pathways with Human Liver Microsomes and Recombinant Human Enzymes

Drug metabolism and disposition, 2024-03, Vol.52 (3), p.242-251

2024

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Characterization of peptide adducts formed via novel reactive intermediates of the CB1 antagonist rimonabant in a model electrochemical system and human liver microsomes

Toxicology letters, 2014-09, Vol.229, p.S248-S248

2014

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Can Silicon Make an Excellent Drug Even Better? An in vitro and in vivo Head-to-Head Comparison between Loperamide and Its Silicon Analogue Sila-Loperamide

ChemMedChem, 2015-05, Vol.10 (5), p.911-924

2015

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Oxygen Surrogate Systems for Supporting Human Drug-Metabolizing Cytochrome P450 Enzymes

Drug metabolism and disposition, 2020-06, Vol.48 (6), p.432-437

2020

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Application of Accelerator Mass Spectrometry to Characterize the Mass Balance Recovery and Disposition of AZD4831, a Novel Myeloperoxidase Inhibitor, following Administration of an Oral Radiolabeled Microtracer Dose in Humans

Drug metabolism and disposition, 2023-04, Vol.51 (4), p.451-463

2023

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Covalent interactions of reactive rimonabant metabolites with biological targets

Toxicology letters, 2014-09, Vol.229, p.S249-S249

2014

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In vitro metabolism of haloperidol and sila-haloperidol: new metabolic pathways resulting from carbon/silicon exchange

Engineering highly functional thermostable proteins using ancestral sequence reconstruction

Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design

Novel metabolites of amodiaquine formed by CYP1A1 and CYP1B1: structure elucidation using electrochemistry, mass spectrometry, and NMR

Development and Evaluation of an Electrochemical Method for Studying Reactive Phase-I Metabolites: Correlation to in Vitro Drug Metabolism

Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions

Early human in vivo pharmacokinetic predictions in drug discovery

The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold

Electrochemical generation of reactive drug metabolites – Applications in drug discovery and development

Electrochemical Oxidation of Troglitazone: Identification and Characterization of the Major Reactive Metabolite in Liver Microsomes

In vitro mimicry of metabolic oxidation reactions by electrochemistry/mass spectrometry

Mimicry of phase I drug metabolism - novel methods for metabolite characterization and synthesis

Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S‑Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes

Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents

Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction

Use of Electrochemical Oxidation and Model Peptides To Study Nucleophilic Biological Targets of Reactive Metabolites: The Case of Rimonabant

Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans

Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates

Correction to “Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction”

Biocatalysis using Thermostable Cytochrome P450 Enzymes in Bacterial Membranes - Comparison of Metabolic Pathways with Human Liver Microsomes and Recombinant Human Enzymes

Characterization of peptide adducts formed via novel reactive intermediates of the CB1 antagonist rimonabant in a model electrochemical system and human liver microsomes

Can Silicon Make an Excellent Drug Even Better? An in vitro and in vivo Head-to-Head Comparison between Loperamide and Its Silicon Analogue Sila-Loperamide

Oxygen Surrogate Systems for Supporting Human Drug-Metabolizing Cytochrome P450 Enzymes

Application of Accelerator Mass Spectrometry to Characterize the Mass Balance Recovery and Disposition of AZD4831, a Novel Myeloperoxidase Inhibitor, following Administration of an Oral Radiolabeled Microtracer Dose in Humans

Covalent interactions of reactive rimonabant metabolites with biological targets

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