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Linking stochastic fluctuations in chromatin structure and gene expression

PLoS biology, 2013-08, Vol.11 (8), p.e1001621-e1001621

2013

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Broad variation in response of individual introns to splicing inhibitors in a humanized yeast strain

RNA (Cambridge), 2024-02, Vol.30 (2), p.149

2024

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Spliceosome database: a tool for tracking components of the spliceosome

Nucleic acids research, 2013-01, Vol.41 (Database issue), p.D132

2013

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U2 snRNA structure is influenced by SF3A and SF3B proteins but not by SF3B inhibitors

PloS one, 2021-10, Vol.16 (10), p.e0258551-e0258551

2021

Volltextzugriff (PDF)

Modulating splicing with small molecular inhibitors of the spliceosome

Wiley interdisciplinary reviews. RNA, 2017-03, Vol.8 (2), p.np-n/a

2017

Volltextzugriff (PDF)

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

Nucleic acids research, 2010-10, Vol.38 (19), p.6664

2010

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Pre-mRNA Splicing: Awash in a Sea of Proteins

Molecular Cell, 2003-07, Vol.12 (1), p.5-14

2003

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Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors

Journal of natural products (Washington, D.C.), 2021-05, Vol.84 (5), p.1681-1706

2021

Volltextzugriff (PDF)

A model for DHX15 mediated disassembly of A-complex spliceosomes

RNA (Cambridge), 2022-04, Vol.28 (4), p.583-595

2022

Volltextzugriff (PDF)

Copper-Catalyzed Stille Cross-Coupling Reaction and Application in the Synthesis of the Spliceostatin Core Structure

Journal of organic chemistry, 2020-06, Vol.85 (12), p.8111-8120

2020

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Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

Nature communications, 2021-07, Vol.12 (1), p.4491-4491, Article 4491

2021

Volltextzugriff (PDF)

Enantioselective Synthesis of Spliceostatin G and Evaluation of Bioactivity of Spliceostatin G and Its Methyl Ester

Organic letters, 2018-01, Vol.20 (1), p.96-99

2018

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Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages

RNA (Cambridge), 2016-03, Vol.22 (3), p.350-359

2016

Volltextzugriff (PDF)

Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in Vitro Splicing Inhibition

Journal of organic chemistry, 2018-05, Vol.83 (9), p.5187-5198

2018

Volltextzugriff (PDF)

Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity

Organic letters, 2018-11, Vol.20 (22), p.7293-7297

2018

Volltextzugriff (PDF)

Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs

The Journal of biological chemistry, 2014-01, Vol.289 (4), p.1938-1947

2014

Volltextzugriff (PDF)

Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

Cell chemical biology, 2020-11, Vol.27 (11), p.1359-1370.e8

2020

Volltextzugriff (PDF)

Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives

Journal of organic chemistry, 2014-06, Vol.79 (12), p.5697-5709

2014

Volltextzugriff (PDF)

A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

Cell chemical biology, 2021-08, Vol.28 (8), p.1145-1157.e6

2021

Volltextzugriff (PDF)

Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core

RNA (Cambridge), 2005-12, Vol.11 (12), p.1869-1883

2005

Volltextzugriff (PDF)

Design and synthesis of herboxidiene derivatives that potently inhibit in vitro splicing

Organic & biomolecular chemistry, 2021-02, Vol.19 (6), p.1365-1377

2021

Volltextzugriff (PDF)

Herboxidiene Features That Mediate Conformation-Dependent SF3B1 Interactions to Inhibit Splicing

ACS chemical biology, 2021-03, Vol.16 (3), p.520-528

2021

Volltextzugriff (PDF)

Rearrangements within human spliceosomes captured after exon ligation

RNA (Cambridge), 2013-03, Vol.19 (3), p.400-412

2013

Volltextzugriff (PDF)

Prp8 positioning of U5 snRNA is linked to 5' splice site recognition

RNA (Cambridge), 2018-06, Vol.24 (6), p.769-777

2018

Volltextzugriff (PDF)

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

RNA (Cambridge), 2002-04, Vol.8 (4), p.426-439, Article S1355838202021088

2002

Volltextzugriff (PDF)

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Linking stochastic fluctuations in chromatin structure and gene expression

Broad variation in response of individual introns to splicing inhibitors in a humanized yeast strain

Spliceosome database: a tool for tracking components of the spliceosome

U2 snRNA structure is influenced by SF3A and SF3B proteins but not by SF3B inhibitors

Modulating splicing with small molecular inhibitors of the spliceosome

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

Pre-mRNA Splicing: Awash in a Sea of Proteins

Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors

A model for DHX15 mediated disassembly of A-complex spliceosomes

Copper-Catalyzed Stille Cross-Coupling Reaction and Application in the Synthesis of the Spliceostatin Core Structure

Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

Enantioselective Synthesis of Spliceostatin G and Evaluation of Bioactivity of Spliceostatin G and Its Methyl Ester

Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages

Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in Vitro Splicing Inhibition

Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity

Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs

Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives

A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core

Design and synthesis of herboxidiene derivatives that potently inhibit in vitro splicing

Herboxidiene Features That Mediate Conformation-Dependent SF3B1 Interactions to Inhibit Splicing

Rearrangements within human spliceosomes captured after exon ligation

Prp8 positioning of U5 snRNA is linked to 5' splice site recognition

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

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