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Site-specific antibody drug conjugates for cancer therapy

mAbs, 2014-01, Vol.6 (1), p.34-45

2014

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Exploration of the antibody-drug conjugate clinical landscape

mAbs, 2023-12, Vol.15 (1), p.2229101-2229101

2023

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High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

Bioconjugate chemistry, 2018-02, Vol.29 (2), p.473-485

2018

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Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

Communications biology, 2021-04, Vol.4 (1), p.475-11, Article 475

2021

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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Nature biotechnology, 2008-08, Vol.26 (8), p.925-932

2008

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Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry

Analytical biochemistry, 2011-05, Vol.412 (1), p.56-66

2011

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Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma

Blood, 2009-09, Vol.114 (13), p.2721-2729

2009

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Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice

Diabetologia, 2015-07, Vol.58 (7), p.1587-1600

2015

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Characterization of the Role of the Rab GTPase-activating Protein AS160 in Insulin-regulated GLUT4 Trafficking

The Journal of biological chemistry, 2005-11, Vol.280 (45), p.37803-37813

2005

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Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway

The Journal of biological chemistry, 2015-10, Vol.290 (43), p.25834-25846

2015

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Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes

The Journal of biological chemistry, 2012-02, Vol.287 (9), p.6128-6138

2012

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An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer

Molecular cancer therapeutics, 2018-03, Vol.17 (3), p.638-649

2018

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Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs

Journal of immunological methods, 2008-03, Vol.332 (1), p.41-52

2008

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CLT030, a leukemic stem cell–targeting CLL1 antibody-drug conjugate for treatment of acute myeloid leukemia

Blood advances, 2018-07, Vol.2 (14), p.1738-1749

2018

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Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria

The EMBO journal, 2013-03, Vol.32 (5), p.713-727

2013

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Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase

The EMBO journal, 2005-06, Vol.24 (12), p.2064-2074

2005

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Rab14 is involved in membrane trafficking between the Golgi complex and endosomes

Molecular biology of the cell, 2004-05, Vol.15 (5), p.2218-2229

2004

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Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells

Journal of cell science, 2013-10, Vol.126 (Pt 20), p.4647-4658

2013

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Emerging role of immunoPET in receptor targeted cancer therapy

Current drug delivery, 2011-01, Vol.8 (1), p.70

2011

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Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene

Proceedings of the National Academy of Sciences - PNAS, 2007-01, Vol.104 (4), p.1236-1241

2007

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Molecular Characterization of Rab11 Interactions with Members of the Family of Rab11-interacting Proteins

The Journal of biological chemistry, 2004-08, Vol.279 (32), p.33430-33437

2004

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Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

Chemical science (Cambridge), 2017-01, Vol.8 (1), p.366-370

2017

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The RCP-Rab11 complex regulates endocytic protein sorting

Molecular biology of the cell, 2004-08, Vol.15 (8), p.3530-3541

2004

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An improved and robust DNA immunization method to develop antibodies against extra-cellular loops of multi-transmembrane proteins

mAbs, 2014-01, Vol.6 (1), p.95-107

2014

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Site-specific antibody drug conjugates for cancer therapy

Exploration of the antibody-drug conjugate clinical landscape

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry

Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma

Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice

Characterization of the Role of the Rab GTPase-activating Protein AS160 in Insulin-regulated GLUT4 Trafficking

Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway

Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes

An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer

Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs

CLT030, a leukemic stem cell–targeting CLL1 antibody-drug conjugate for treatment of acute myeloid leukemia

Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria

Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase

Rab14 is involved in membrane trafficking between the Golgi complex and endosomes

Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells

Emerging role of immunoPET in receptor targeted cancer therapy

Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene

Molecular Characterization of Rab11 Interactions with Members of the Family of Rab11-interacting Proteins

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

The RCP-Rab11 complex regulates endocytic protein sorting

An improved and robust DNA immunization method to develop antibodies against extra-cellular loops of multi-transmembrane proteins

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