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Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain

ACS medicinal chemistry letters, 2017-12, Vol.8 (12), p.1309-1313

2017

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The Absolute Configuration and Asymmetric Total Synthesis of the CP Molecules (CP-263,114 and CP-225,917, Phomoidrides B and A)

Angewandte Chemie International Edition, 2000-05, Vol.39 (10), p.1829-1832

2000

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(1a R ,5a R )1a,3,5,5a-Tetrahydro-1 H -2,3-diaza-cyclopropa[ a ]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans

Journal of medicinal chemistry, 2012-04, Vol.55 (8), p.3644-3666

2012

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Synthesis and biological evaluation of deoxypreussomerin A and palmarumycin CP1 and related naphthoquinone spiroketals

Tetrahedron, 2001-01, Vol.57 (2), p.283-296

2001

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Formal Total Synthesis of (+)-Diepoxin σ

Journal of organic chemistry, 2000-10, Vol.65 (20), p.6319-6337

2000

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Nucleophilic Additions to 4,4-Disubstituted 2,5-Cyclohexadienones: Can Dipole Effects Control Facial Selectivity?

Chemical reviews, 1999-05, Vol.99 (5), p.1469-1480

1999

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3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice

Journal of medicinal chemistry, 2008-08, Vol.51 (16), p.5101-5108

2008

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New inhibitors of the thioredoxin–thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead

Bioorganic & medicinal chemistry letters, 2001-10, Vol.11 (19), p.2637-2641

2001

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Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.322-326

2015

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Analogues of Acifran: Agonists of the High and Low Affinity Niacin Receptors, GPR109a and GPR109b

Journal of medicinal chemistry, 2007-04, Vol.50 (7), p.1445-1448

2007

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Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (9), p.2797-2800

2010

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GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole–tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (8), p.2121-2124

2009

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GPR109a agonists. Part 2: Pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4472-4474

2010

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Agonist lead identification for the high affinity niacin receptor GPR109a

Bioorganic & medicinal chemistry letters, 2007-09, Vol.17 (17), p.4914-4919

2007

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Long-Range Electrostatic Effects in Synthesis: Dipole-Controlled Nucleophilic Addition to a Naphthoquinone Acetal in Model Studies toward Diepoxin σ

Angewandte Chemie International Edition, 1997-04, Vol.36 (7), p.764-767

1997

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Total Synthesis of the Spiroketal Naphthoquinone (±)-Diepoxin σ

Journal of organic chemistry, 1999-02, Vol.64 (4), p.1092-1093

1999

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Total Synthesis of Palmarumycin CP1 and (±)-Deoxypreussomerin A

Journal of organic chemistry, 1998-05, Vol.63 (11), p.3530-3531

1998

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Antimitotic actions of a novel analog of the fungal metabolite palmarumycin CP1

The Journal of pharmacology and experimental therapeutics, 2001-02, Vol.296 (2), p.364

2001

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(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans

Journal of medicinal chemistry, 2012-04, Vol.55 (8), p.3644-3666

2012

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Discovery of APD371: Identification of a Highly Potent and Selective CB 2 Agonist for the Treatment of Chronic Pain

ACS medicinal chemistry letters, 2017-12, Vol.8 (12), p.1309-1313

2017

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Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxam i des as potent and selective CB sub(2) receptor agonists

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.322-326

2015

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The Absolute Configuration and Asymmetric Total Synthesis of the CP Molecules (CP-263,114 and CP-225,917, Phomoidrides B and A)

Angewandte Chemie, 2000-05, Vol.112 (10), p.1899-1902

2000

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ChemInform Abstract: Formal Total Synthesis of (+)-Diepoxin σ

ChemInform, 2001-02, Vol.32 (6), p.no-no

2001

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ChemInform Abstract: Total Synthesis of the Spiroketal Naphthoquinone (.+-.)-Diepoxin σ

ChemInform, 1999-07, Vol.30 (29), p.no-no

1999

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ChemInform Abstract: Nucleophilic Additions to 4,4-Disubstituted 2,5-Cyclohexadienones: Can Dipole Effects Control Facial Selectivity?

ChemInform, 1999-07, Vol.30 (29), p.no-no

1999

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Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain

The Absolute Configuration and Asymmetric Total Synthesis of the CP Molecules (CP-263,114 and CP-225,917, Phomoidrides B and A)

(1a R ,5a R )1a,3,5,5a-Tetrahydro-1 H -2,3-diaza-cyclopropa[ a ]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans

Synthesis and biological evaluation of deoxypreussomerin A and palmarumycin CP1 and related naphthoquinone spiroketals

Formal Total Synthesis of (+)-Diepoxin σ

Nucleophilic Additions to 4,4-Disubstituted 2,5-Cyclohexadienones: Can Dipole Effects Control Facial Selectivity?

3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice

New inhibitors of the thioredoxin–thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead

Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists

Analogues of Acifran: Agonists of the High and Low Affinity Niacin Receptors, GPR109a and GPR109b

Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)

GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole–tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a

GPR109a agonists. Part 2: Pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a

Agonist lead identification for the high affinity niacin receptor GPR109a

Long-Range Electrostatic Effects in Synthesis: Dipole-Controlled Nucleophilic Addition to a Naphthoquinone Acetal in Model Studies toward Diepoxin σ

Total Synthesis of the Spiroketal Naphthoquinone (±)-Diepoxin σ

Total Synthesis of Palmarumycin CP1 and (±)-Deoxypreussomerin A

Antimitotic actions of a novel analog of the fungal metabolite palmarumycin CP1

(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans

Discovery of APD371: Identification of a Highly Potent and Selective CB 2 Agonist for the Treatment of Chronic Pain

Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxam i des as potent and selective CB sub(2) receptor agonists

The Absolute Configuration and Asymmetric Total Synthesis of the CP Molecules (CP-263,114 and CP-225,917, Phomoidrides B and A)

ChemInform Abstract: Formal Total Synthesis of (+)-Diepoxin σ

ChemInform Abstract: Total Synthesis of the Spiroketal Naphthoquinone (.+-.)-Diepoxin σ

ChemInform Abstract: Nucleophilic Additions to 4,4-Disubstituted 2,5-Cyclohexadienones: Can Dipole Effects Control Facial Selectivity?

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