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Adoptive T cell therapy for cancer in the clinic

The Journal of clinical investigation, 2007-06, Vol.117 (6), p.1466-1476

June, Carl H

2007

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Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

Immunity (Cambridge, Mass.), 2009-05, Vol.30 (5), p.656-665

2009

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CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia

Leukemia, 2015-08, Vol.29 (8), p.1637-1647

2015

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NEXT GENERATION CAR T CELLS FOR LYMPHOMA AND BEYOND

Hematological oncology, 2019-06, Vol.37 (S2), p.34-34

June, C.H.

2019

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Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells

Science translational medicine, 2012-05, Vol.4 (132), p.132ra53

2012

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The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation

Blood, 2005-01, Vol.105 (1), p.13-21

2005

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Generation and Large‐Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft‐Versus‐Host Disease

American journal of transplantation, 2011-06, Vol.11 (6), p.1148-1157

2011

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Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

Science (American Association for the Advancement of Science), 1989-04, Vol.244 (4902), p.339-343

1989

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SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation

The Journal of immunology (1950), 2004-07, Vol.173 (2), p.945-954

2004

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Putting the brakes on BTLA in T cell-mediated cancer immunotherapy

The Journal of clinical investigation, 2010-01, Vol.120 (1), p.76-80

2010

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4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies

Human gene therapy, 2010-01, Vol.21 (1), p.75-86

2010

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CD28 Activation Pathway Regulates the Production of Multiple T-Cell-Derived Lymphokines/Cytokines

Proceedings of the National Academy of Sciences - PNAS, 1989-02, Vol.86 (4), p.1333-1337

1989

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The CD28 Signaling Pathway Regulates Glucose Metabolism

Immunity (Cambridge, Mass.), 2002-06, Vol.16 (6), p.769-777

2002

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Regulatory CD4+CD25+ T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer

Cancer research (Chicago, Ill.), 2001-06, Vol.61 (12), p.4766-4772

2001

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Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation

The Journal of immunology (1950), 2002-05, Vol.168 (9), p.4272-4276

2002

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L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection

Blood, 2004-12, Vol.104 (12), p.3804-3812

2004

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In vitro–expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell–stimulated MLR cultures

Blood, 2004-07, Vol.104 (2), p.453-461

2004

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Cord blood CD4+CD25+-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function

Blood, 2005-01, Vol.105 (2), p.750-758

2005

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Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig-coated artificial antigen-presenting cells

Nature medicine, 2003-05, Vol.9 (5), p.619-625

2003

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Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer

Nature medicine, 2005-11, Vol.11 (11), p.1230-1237

2005

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A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation

Blood, 2006-02, Vol.107 (4), p.1325-1331

2006

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Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB

Nature biotechnology, 2002-02, Vol.20 (2), p.143-148

2002

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Clinical application of expanded CD4 +25 + cells

Seminars in immunology, 2006-04, Vol.18 (2), p.78-88

2006

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CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy

Blood, 2005-11, Vol.106 (9), p.3068-3073

2005

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Modulation of TCR-Induced Transcriptional Profiles by Ligation of CD28, ICOS, and CTLA-4 Receptors

Proceedings of the National Academy of Sciences - PNAS, 2002-09, Vol.99 (18), p.11790-11795

2002

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Adoptive T cell therapy for cancer in the clinic

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia

NEXT GENERATION CAR T CELLS FOR LYMPHOMA AND BEYOND

Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation

Generation and Large‐Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft‐Versus‐Host Disease

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation

Putting the brakes on BTLA in T cell-mediated cancer immunotherapy

4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies

CD28 Activation Pathway Regulates the Production of Multiple T-Cell-Derived Lymphokines/Cytokines

The CD28 Signaling Pathway Regulates Glucose Metabolism

Regulatory CD4+CD25+ T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer

Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation

L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection

In vitro–expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell–stimulated MLR cultures

Cord blood CD4+CD25+-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function

Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig-coated artificial antigen-presenting cells

Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer

A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation

Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB

Clinical application of expanded CD4 +25 + cells

CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy

Modulation of TCR-Induced Transcriptional Profiles by Ligation of CD28, ICOS, and CTLA-4 Receptors

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