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Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain

The Journal of neuroscience, 2016-12, Vol.36 (49), p.12485-12497

2016

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Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo

Scientific reports, 2018-01, Vol.8 (1), p.1552-18, Article 1552

2018

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Behavioural and dopaminergic changes in double mutated human A30PA53T alpha-synuclein transgenic mouse model of Parkinson´s disease

Scientific reports, 2019-11, Vol.9 (1), p.17382-13, Article 17382

2019

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Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A

Pharmacological research, 2020-01, Vol.151, p.104558, Article 104558

2020

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New tricks of prolyl oligopeptidase inhibitors – A common drug therapy for several neurodegenerative diseases

Biochemical pharmacology, 2019-03, Vol.161, p.113-120

2019

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Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner

International journal of molecular sciences, 2021-02, Vol.22 (4), p.1777

2021

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Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model

Neuropharmacology, 2022-11, Vol.218, p.109213-109213, Article 109213

2022

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A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy

Science translational medicine, 2023-04, Vol.15 (691), p.eabq2915

2023

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Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α‑Synuclein Mouse Models of Parkinson’s Disease

Journal of medicinal chemistry, 2023-06, Vol.66 (11), p.7475-7496

2023

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Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Fluids and barriers of the CNS, 2022-12, Vol.19 (1), p.99-99, Article 99

2022

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Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson’s Disease

Neuroscience, 2018-03, Vol.374, p.250-263

2018

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Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Alzheimer's research & therapy, 2023-05, Vol.15 (1), p.90-90, Article 90

2023

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Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Pharmaceutics, 2022-07, Vol.14 (7), p.1412

2022

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Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse

Molecular neurobiology, 2018-01, Vol.55 (1), p.470-482

2018

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Multiplexed analysis of amino acids in mice brain microdialysis samples using isobaric labeling and liquid chromatography-high resolution tandem mass spectrometry

Journal of Chromatography A, 2021-10, Vol.1656, p.462537, Article 462537

2021

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PET Imaging in Preclinical Anti-Aβ Drug Development

Pharmaceutical research, 2022-07, Vol.39 (7), p.1481-1496

2022

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Novel Small‐Molecular Ligands for Prolyl Oligopeptidase to Combat Tauopathies

Alzheimer's & dementia, 2023-12, Vol.19 (S21), p.n/a

2023

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Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the [alpha]-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing [alpha]-Synuclein Oligomeric Species in Mouse Brain

The Journal of neuroscience, 2016-12, Vol.36 (49), p.12485-12497

2016

Volltextzugriff (PDF)

Brain pharmacokinetics of mono- and bispecific amyloid-[beta] antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Fluids and barriers of the CNS, 2022-12, Vol.19 (1)

2022

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Long-term effects of immunotherapy with a brain penetrating A[beta] antibody in a mouse model of Alzheimer's disease

Alzheimer's research & therapy, 2023-05, Vol.15 (1)

2023

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Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain

Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo

Behavioural and dopaminergic changes in double mutated human A30PA53T alpha-synuclein transgenic mouse model of Parkinson´s disease

Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A

New tricks of prolyl oligopeptidase inhibitors – A common drug therapy for several neurodegenerative diseases

Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner

Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model

A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy

Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α‑Synuclein Mouse Models of Parkinson’s Disease

Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson’s Disease

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse

Multiplexed analysis of amino acids in mice brain microdialysis samples using isobaric labeling and liquid chromatography-high resolution tandem mass spectrometry

PET Imaging in Preclinical Anti-Aβ Drug Development

Novel Small‐Molecular Ligands for Prolyl Oligopeptidase to Combat Tauopathies

Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the [alpha]-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing [alpha]-Synuclein Oligomeric Species in Mouse Brain

Brain pharmacokinetics of mono- and bispecific amyloid-[beta] antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Long-term effects of immunotherapy with a brain penetrating A[beta] antibody in a mouse model of Alzheimer's disease

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