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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Science (American Association for the Advancement of Science), 2020-02, Vol.367 (6478), p.643-652

2020

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Structural Insights into FGFR Kinase Isoform Selectivity: Diverse Binding Modes of AZD4547 and Ponatinib in Complex with FGFR1 and FGFR4

Structure (London), 2014-12, Vol.22 (12), p.1764-1774

2014

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The thrombopoietin receptor: revisiting the master regulator of platelet production

Platelets (Edinburgh), 2021-08, Vol.32 (6), p.770-778

2021

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Comparative study of the hot processing behavior in advanced Ni-based superalloys for use in A-USC applications

Journal of alloys and compounds, 2020-03, Vol.818, p.152907, Article 152907

2020

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Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for

Biochemical Society transactions, 2020-10, Vol.48 (5), p.1859-1875

2020

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Recent Advances in Kinase Drug Discovery Part I: The Editors’ Take

International journal of molecular sciences, 2021-07, Vol.22 (14), p.7560

2021

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Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives

PloS one, 2012-12, Vol.7 (12), p.e50889-e50889

2012

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Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors

Nature communications, 2020-03, Vol.11 (1), p.1383-1383, Article 1383

2020

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Prevalence of moderate or greater permanent childhood hearing impairment and effectiveness of targeted surveillance for babies who pass newborn hearing screening

International journal of audiology, 2024-08, Vol.ahead-of-print (ahead-of-print), p.1-8

2024

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Evaluation of Microstructural Evolution in Isothermally Aged Ferritic Candidate Cladding Materials for Sodium-cooled Fast Reactor Applications

Microscopy and microanalysis, 2022-08, Vol.28 (S1), p.2084-2084

2022

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Keep it together: restraints in crystallographic refinement of macromolecule–ligand complexes

Acta crystallographica. Section D, Biological crystallography., 2017-02, Vol.73 (2), p.93-102

2017

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An atom probe perspective on phase separation and precipitation in duplex stainless steels

Nanotechnology, 2016-06, Vol.27 (25), p.254004-254004

2016

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Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis

Cell, 2023-09, Vol.186 (19), p.4189-4203.e22

2023

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Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2265-2274

2015

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Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

Journal of medicinal chemistry, 2012-04, Vol.55 (7), p.3285-3306

2012

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Cyclic and time-dependent crack growth mechanisms in Alloy 617 at 800 °C

Materials science & engineering. A, Structural materials : properties, microstructure and processing, 2018-11, Vol.737 (C), p.205-212

2018

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Validation of ion mobility spectrometry - mass spectrometry as a screening tool to identify type II kinase inhibitors of FGFR1 kinase

Rapid communications in mass spectrometry, 2021-06, p.e9130-e9130

2021

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Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides

Journal of medicinal chemistry, 2018-12, Vol.61 (23), p.10767-10792

2018

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Characterization of Irradiated 309L Stainless Steel Cladding Produced by Laser Directed Energy Deposition

Microscopy and microanalysis, 2022-08, Vol.28 (S1), p.2068-2068

2022

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Corrigendum to “Cyclic and time-dependent crack growth mechanisms in Alloy 617 at 800 °C” [Mater. Sci. Eng. A 737 (2018) 205–212]

Materials science & engineering. A, Structural materials : properties, microstructure and processing, 2019-09, Vol.764, p.138207, Article 138207

2019

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Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

Nature communications, 2015-07, Vol.6 (1), p.7877-7877, Article 7877

2015

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Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

Journal of medicinal chemistry, 2022-05, Vol.65 (9), p.6513-6540

2022

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Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3‑Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors

Journal of medicinal chemistry, 2015-01, Vol.58 (2), p.753-766

2015

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Phase Separation in Lean-Grade Duplex Stainless Steel 2101

JOM (1989), 2015-10, Vol.67 (10), p.2216-2222

2015

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How Tyrosine 15 Phosphorylation Inhibits the Activity of Cyclin-dependent Kinase 2-Cyclin A

The Journal of biological chemistry, 2007-02, Vol.282 (5), p.3173-3181

2007

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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Structural Insights into FGFR Kinase Isoform Selectivity: Diverse Binding Modes of AZD4547 and Ponatinib in Complex with FGFR1 and FGFR4

The thrombopoietin receptor: revisiting the master regulator of platelet production

Comparative study of the hot processing behavior in advanced Ni-based superalloys for use in A-USC applications

Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for

Recent Advances in Kinase Drug Discovery Part I: The Editors’ Take

Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors

Prevalence of moderate or greater permanent childhood hearing impairment and effectiveness of targeted surveillance for babies who pass newborn hearing screening

Evaluation of Microstructural Evolution in Isothermally Aged Ferritic Candidate Cladding Materials for Sodium-cooled Fast Reactor Applications

Keep it together: restraints in crystallographic refinement of macromolecule–ligand complexes

An atom probe perspective on phase separation and precipitation in duplex stainless steels

Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

Cyclic and time-dependent crack growth mechanisms in Alloy 617 at 800 °C

Validation of ion mobility spectrometry - mass spectrometry as a screening tool to identify type II kinase inhibitors of FGFR1 kinase

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides

Characterization of Irradiated 309L Stainless Steel Cladding Produced by Laser Directed Energy Deposition

Corrigendum to “Cyclic and time-dependent crack growth mechanisms in Alloy 617 at 800 °C” [Mater. Sci. Eng. A 737 (2018) 205–212]

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3‑Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors

Phase Separation in Lean-Grade Duplex Stainless Steel 2101

How Tyrosine 15 Phosphorylation Inhibits the Activity of Cyclin-dependent Kinase 2-Cyclin A

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