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Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles

Nature reviews. Drug discovery, 2019-11, Vol.18 (11), p.845-867

2019

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RACK1 Controls IRES-Mediated Translation of Viruses

Cell, 2014-11, Vol.159 (5), p.1086-1095

2014

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Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells

Cell reports (Cambridge), 2024-02, Vol.43 (2), p.113677-113677, Article 113677

2024

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Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila

The Journal of immunology (1950), 2013-01, Vol.190 (2), p.650-658

2013

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Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity

Journal of virology, 2016-06, Vol.90 (11), p.5415-5426

2016

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Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila

Nature Immunology, 2006-06, Vol.7 (6), p.590-597

2006

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The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila

Nature immunology, 2008-12, Vol.9 (12), p.1425-1432

2008

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Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila

Proceedings of the National Academy of Sciences - PNAS, 2016-01, Vol.113 (3), p.698-703

2016

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Drosophila C virus systemic infection leads to intestinal obstruction

Journal of virology, 2014-12, Vol.88 (24), p.14057-14069

2014

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A model of bacterial intestinal infections in Drosophila melanogaster

PLoS pathogens, 2007-11, Vol.3 (11), p.e173-e173

2007

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Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2

PLoS pathogens, 2006-02, Vol.2 (2), p.e14-e14

2006

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Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors

Cell, 2006-12, Vol.127 (7), p.1425-1437

2006

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big bang gene modulates gut immune tolerance in Drosophila

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (8), p.2957-2962

2013

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Genetic analysis of resistance to viral infection

Nature Reviews: Immunology, 2007-10, Vol.7 (10), p.753-766

2007

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RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila

Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (45), p.19390-19395

2010

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Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium

Cell host & microbe, 2009-03, Vol.5 (3), p.273-284

2009

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Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein

Nature (London), 2001-12, Vol.414 (6865), p.756-759

2001

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Single Cell Analysis of the Fate of Injected Oncogenic RasV12 Cells in Adult Wild Type Drosophila

Journal of innate immunity, 2023-01, Vol.15 (1), p.442-467

2023

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Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila

Cell, 2005-10, Vol.123 (2), p.335-346

2005

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Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif

PloS one, 2012-08, Vol.7 (8), p.e42725-e42725

2012

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The N-terminal Domain of Drosophila Gram-negative Binding Protein 3 (GNBP3) Defines a Novel Family of Fungal Pattern Recognition Receptors

The Journal of biological chemistry, 2009-10, Vol.284 (42), p.28687-28697

2009

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The immune response of Drosophila

Nature, 2003-11, Vol.426 (6962), p.33-38

Hoffmann, Jules A

2003

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Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria

Nature immunology, 2004-11, Vol.5 (11), p.1175-1180

2004

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ATP-sensitive potassium channel (KATP)-dependent regulation of cardiotropic viral infections

Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (29), p.12024-12029

2011

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Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

Nature immunology, 2003-08, Vol.4 (8), p.794-800

2003

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Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles

RACK1 Controls IRES-Mediated Translation of Viruses

Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells

Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila

Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity

Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila

The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila

Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila

Drosophila C virus systemic infection leads to intestinal obstruction

A model of bacterial intestinal infections in Drosophila melanogaster

Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2

Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors

big bang gene modulates gut immune tolerance in Drosophila

Genetic analysis of resistance to viral infection

RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila

Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein

Single Cell Analysis of the Fate of Injected Oncogenic RasV12 Cells in Adult Wild Type Drosophila

Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila

Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif

The N-terminal Domain of Drosophila Gram-negative Binding Protein 3 (GNBP3) Defines a Novel Family of Fungal Pattern Recognition Receptors

The immune response of Drosophila

Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria

ATP-sensitive potassium channel (KATP)-dependent regulation of cardiotropic viral infections

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

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