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Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

European journal of medicinal chemistry, 2019-04, Vol.168, p.491-514

2019

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Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy

Molecules (Basel, Switzerland), 2017-07, Vol.22 (8), p.1265

2017

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In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2018-05, Vol.14 (3), p.281

2018

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A systematic evaluation of the cucurbit[7]uril pharmacokinetics and toxicity after a single dose and short-term repeated administration in mice

Archives of toxicology, 2022-05, Vol.96 (5), p.1411-1421

2022

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In vitro stress response induced by sulfur mustard in lung fibroblasts NHLF and human pulmonary epithelial cells A-549

Archives of toxicology, 2020-10, Vol.94 (10), p.3503-3514

2020

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Magnetoconductive maghemite core/polyaniline shell nanoparticles: Physico-chemical and biological assessment

Colloids and surfaces, B, Biointerfaces, 2016-05, Vol.141, p.382-389

2016

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Induction and repair of DNA cross-links induced by sulfur mustard in the A-549 cell line followed by a comet assay

Chemico-biological interactions, 2015-07, Vol.237, p.31-37

2015

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Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.8985-9003

2015

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Differentiated SH-SY5Y neuroblastoma cells as a model for evaluation of nerve agent-associated neurotoxicity

Archives of toxicology, 2023-08, Vol.97 (8), p.2209-2217

2023

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Antibiofilm activity of bioactive hop compounds humulone, lupulone and xanthohumol toward susceptible and resistant staphylococci

Research in microbiology, 2018-04, Vol.169 (3), p.127-134

2018

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Epigallocatechin gallate inhibits Francisella tularensis growth and suppresses the function of DNA-binding protein HU

Microbial pathogenesis, 2023-03, Vol.176, p.105999, Article 105999

2023

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Protective potential of different compounds and their combinations with MESNA against sulfur mustard-induced cytotoxicity and genotoxicity

Toxicology letters, 2017-06, Vol.275, p.92-100

2017

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Cytotoxicity of acetylcholinesterase reactivators evaluated in vitro and its relation to their structure

Drug and chemical toxicology (New York, N.Y. 1978), 2019-05, Vol.42 (3), p.252-256

2019

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Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation

Molecules (Basel, Switzerland), 2017-06, Vol.22 (6), p.1006

2017

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Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness

Toxicology letters, 2020-03, Vol.320, p.64-72

2020

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Inter strand crosslinks in DNA induced in vivo by percutaneous application of sulphur mustard to rats and mice

Mutation research. Genetic toxicology and environmental mutagenesis, 2018-08, Vol.832-833, p.35-40

2018

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Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment

Biochimica et biophysica acta. Molecular basis of disease, 2017-02, Vol.1863 (2), p.607-619

2017

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A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299

International journal of molecular sciences, 2019-11, Vol.20 (23), p.5881

2019

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Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide

Journal of applied biomedicine, 2019-06, Vol.17 (2), p.136-145

2019

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Tacrine – Benzothiazoles: Novel class of potential multitarget anti-Alzheimeŕs drugs dealing with cholinergic, amyloid and mitochondrial systems

Bioorganic chemistry, 2021-02, Vol.107, p.104596, Article 104596

2021

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Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

ChemMedChem, 2016-06, Vol.11 (12), p.1264-1269

2016

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Cytotoxicity and genotoxicity evaluation of antidote oxime HI-6 tested on eight cell lines of human and rodent origin

General physiology and biophysics, 2012-03, Vol.31 (1), p.77-84

2012

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A comparison of decontamination effects of commercially available detergents in rats pre-exposed to topical sulphur mustard

Cutaneous and ocular toxicology, 2013-06, Vol.32 (2), p.135-139

2013

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Pooled Safety Analysis of IncobotulinumtoxinA in the Treatment of Neurological Disorders in Adults

Toxins, 2023-05, Vol.15 (6), p.353

2023

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Challenges to scenario-guided adaptive action on food security under climate change

Global environmental change, 2014-09, Vol.28, p.383-394

2014

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Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy

In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?

A systematic evaluation of the cucurbit[7]uril pharmacokinetics and toxicity after a single dose and short-term repeated administration in mice

In vitro stress response induced by sulfur mustard in lung fibroblasts NHLF and human pulmonary epithelial cells A-549

Magnetoconductive maghemite core/polyaniline shell nanoparticles: Physico-chemical and biological assessment

Induction and repair of DNA cross-links induced by sulfur mustard in the A-549 cell line followed by a comet assay

Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

Differentiated SH-SY5Y neuroblastoma cells as a model for evaluation of nerve agent-associated neurotoxicity

Antibiofilm activity of bioactive hop compounds humulone, lupulone and xanthohumol toward susceptible and resistant staphylococci

Epigallocatechin gallate inhibits Francisella tularensis growth and suppresses the function of DNA-binding protein HU

Protective potential of different compounds and their combinations with MESNA against sulfur mustard-induced cytotoxicity and genotoxicity

Cytotoxicity of acetylcholinesterase reactivators evaluated in vitro and its relation to their structure

Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation

Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness

Inter strand crosslinks in DNA induced in vivo by percutaneous application of sulphur mustard to rats and mice

Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment

A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299

Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide

Tacrine – Benzothiazoles: Novel class of potential multitarget anti-Alzheimeŕs drugs dealing with cholinergic, amyloid and mitochondrial systems

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

Cytotoxicity and genotoxicity evaluation of antidote oxime HI-6 tested on eight cell lines of human and rodent origin

A comparison of decontamination effects of commercially available detergents in rats pre-exposed to topical sulphur mustard

Pooled Safety Analysis of IncobotulinumtoxinA in the Treatment of Neurological Disorders in Adults

Challenges to scenario-guided adaptive action on food security under climate change

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