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Discovery of a Novel, Potent Spirocyclic Series of γ‑Secretase Inhibitors

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.8806-8817

2015

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Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors

European journal of medicinal chemistry, 2016-11, Vol.124, p.36-48

2016

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Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.205-207

2007

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Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Bioorganic & medicinal chemistry, 2007-11, Vol.17 (22), p.6290-6294

2007

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2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.57-62

2007

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Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease

Bioorganic & medicinal chemistry letters, 2007-01, Vol.17 (2), p.511-516

2007

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Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2311-2314

2001

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Metabolic stabilization of benzylidene ketal M 2 muscarinic receptor antagonists via halonaphthoic acid substitution

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2311-2314

2001

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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

Nature structural & molecular biology, 2017-07, Vol.24 (7), p.570-577

2017

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Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells

Cell reports (Cambridge), 2016-07, Vol.16 (3), p.622-630

2016

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Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor

Circulation (New York, N.Y.), 2023-07, Vol.148 (2), p.144-158

2023

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Two Phenotypically Distinct Subsets of Spleen Dendritic Cells in Rats Exhibit Different Cytokine Production and T Cell Stimulatory Activity

The Journal of immunology (1950), 2002-09, Vol.169 (5), p.2284-2291

2002

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Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs

Bioorganic & medicinal chemistry letters, 2019-07, Vol.29 (14), p.1842-1848

2019

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A General Synthetic Approach to the (20S)-Camptothecin Family of Antitumor Agents by a Regiocontrolled Cascade Radical Cyclization of Aryl Isonitriles

Chemistry : a European journal, 1998-01, Vol.4 (1), p.67-83

1998

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Design and Synthesis of Novel, Selective GPR40 AgoPAMs

ACS medicinal chemistry letters, 2017-02, Vol.8 (2), p.221-226

2017

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Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity

Journal of medicinal chemistry, 2002-07, Vol.45 (14), p.3143-3160

2002

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Tandem radical reactions of isonitriles with 2-pyridonyl and other aryl radicals: Scope and limitations, and a first generation synthesis of (±)-camptothecin

Tetrahedron, 1996-08, Vol.52 (35), p.11385-11404

1996

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Selective N-functionalization of 6-substituted-2-pyridones

Tetrahedron letters, 1995-12, Vol.36 (49), p.8917-8920

1995

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Nouvelle approche thérapeutique potentielle des ostéosarcomes par immunothérapie active utilisant une sous-population de cellules dendritiques spléniques chez le rat

Morphologie, 2006-06, Vol.90 (289), p.93-93

2006

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Second Generation Synthesis of (20S)-Camptothecin and Derivatives via a Cascade Radical Reaction

Annals of the New York Academy of Sciences, 1996-12, Vol.803 (1), p.310-311

1996

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Discovery of a Novel, Potent Spirocyclic Series of γ‑Secretase Inhibitors

Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors

Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease

Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution

Metabolic stabilization of benzylidene ketal M 2 muscarinic receptor antagonists via halonaphthoic acid substitution

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells

Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor

Two Phenotypically Distinct Subsets of Spleen Dendritic Cells in Rats Exhibit Different Cytokine Production and T Cell Stimulatory Activity

Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs

A General Synthetic Approach to the (20S)-Camptothecin Family of Antitumor Agents by a Regiocontrolled Cascade Radical Cyclization of Aryl Isonitriles

Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo

Design and Synthesis of Novel, Selective GPR40 AgoPAMs

Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity

Tandem radical reactions of isonitriles with 2-pyridonyl and other aryl radicals: Scope and limitations, and a first generation synthesis of (±)-camptothecin

Selective N-functionalization of 6-substituted-2-pyridones

Nouvelle approche thérapeutique potentielle des ostéosarcomes par immunothérapie active utilisant une sous-population de cellules dendritiques spléniques chez le rat

Second Generation Synthesis of (20S)-Camptothecin and Derivatives via a Cascade Radical Reaction

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