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Galactosylation variations in marketed therapeutic antibodies

mAbs, 2012-05, Vol.4 (3), p.385-391

2012

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Cleavage of IgGs by proteases associated with invasive diseases: an evasion tactic against host immunity?

mAbs, 2010-05, Vol.2 (3), p.212-220

2010

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An Atomic-Level View of Melting Using Femtosecond Electron Diffraction

Science (American Association for the Advancement of Science), 2003-11, Vol.302 (5649), p.1382-1385

2003

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Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo

Breast cancer research : BCR, 2018-06, Vol.20 (1), p.43-43, Article 43

2018

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Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function

The Journal of immunology (1950), 2012-12, Vol.189 (11), p.5457-5466

2012

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Proteinase-nicked IgGs: an unanticipated target for tumor immunotherapy

Oncoimmunology, 2018-09, Vol.7 (9), p.e1480300-e1480300

2018

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Femtosecond electron diffraction: ‘making the molecular movie’

Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences, 2006-03, Vol.364 (1840), p.741-778

2006

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Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

Proceedings of the National Academy of Sciences - PNAS, 2009-10, Vol.106 (42), p.17864-17869

2009

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Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid

Molecular immunology, 2008-04, Vol.45 (7), p.1837-1846

2008

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Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge

Proteins, structure, function, and bioinformatics, 2014-08, Vol.82 (8), p.1656-1667

2014

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Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions

Communications biology, 2022-09, Vol.5 (1), p.960-960, Article 960

2022

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Trastuzumab triggers phagocytic killing of high HER2 cancer cells in vitro and in vivo by interaction with Fcγ receptors on macrophages

The Journal of immunology (1950), 2015-05, Vol.194 (9), p.4379-4386

2015

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The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge

mAbs, 2011-11, Vol.3 (6), p.558-567

2011

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Carrier Relaxation and Lattice Heating Dynamics in Silicon Revealed by Femtosecond Electron Diffraction

The journal of physical chemistry. B, 2006-12, Vol.110 (50), p.25308-25313

2006

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Proteolytic Cleavage and Loss of Function of Biologic Agents That Neutralize Tumor Necrosis Factor in the Mucosa of Patients With Inflammatory Bowel Disease

Gastroenterology (New York, N.Y. 1943), 2015-11, Vol.149 (6), p.1564-1574.e3

2015

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The origins, specificity, and potential biological relevance of human anti-IgG hinge autoantibodies

TheScientificWorld, 2011-01, Vol.11, p.1153-1167

2011

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An additional mechanism of action of abciximab: dispersal of newly formed platelet aggregates

Thrombosis and haemostasis, 2002, Vol.87 (6), p.1020-1025

2002

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Ultrafast electron optics: Propagation dynamics of femtosecond electron packets

Journal of applied physics, 2002-08, Vol.92 (3), p.1643-1648

2002

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Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function

Oncoimmunology, 2016-05, Vol.5 (5), p.e1122861-e1122861

2016

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An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

mAbs, 2015-05, Vol.7 (3), p.494-504

2015

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A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy

Breast cancer research : BCR, 2012-08, Vol.14 (4), p.R116-R116, Article R116

2012

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A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies

Molecular cancer therapeutics, 2015-03, Vol.14 (3), p.681-691

2015

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Pictures and the bottom line: The television epistemology of U.S. annual reports

Accounting, organizations and society, 1996, Vol.21 (1), p.57-88

1996

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Femtosecond electron pulse characterization using laser ponderomotive scattering

Optics letters, 2006-12, Vol.31 (23), p.3517

2006

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A peptide immunization approach to counteract a Staphylococcus aureus protease defense against host immunity

Immunology letters, 2016-04, Vol.172, p.29-39

2016

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Galactosylation variations in marketed therapeutic antibodies

Cleavage of IgGs by proteases associated with invasive diseases: an evasion tactic against host immunity?

An Atomic-Level View of Melting Using Femtosecond Electron Diffraction

Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo

Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function

Proteinase-nicked IgGs: an unanticipated target for tumor immunotherapy

Femtosecond electron diffraction: ‘making the molecular movie’

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid

Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge

Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions

Trastuzumab triggers phagocytic killing of high HER2 cancer cells in vitro and in vivo by interaction with Fcγ receptors on macrophages

The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge

Carrier Relaxation and Lattice Heating Dynamics in Silicon Revealed by Femtosecond Electron Diffraction

Proteolytic Cleavage and Loss of Function of Biologic Agents That Neutralize Tumor Necrosis Factor in the Mucosa of Patients With Inflammatory Bowel Disease

The origins, specificity, and potential biological relevance of human anti-IgG hinge autoantibodies

An additional mechanism of action of abciximab: dispersal of newly formed platelet aggregates

Ultrafast electron optics: Propagation dynamics of femtosecond electron packets

Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy

A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies

Pictures and the bottom line: The television epistemology of U.S. annual reports

Femtosecond electron pulse characterization using laser ponderomotive scattering

A peptide immunization approach to counteract a Staphylococcus aureus protease defense against host immunity

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