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Hyposecretion, Not Hyperabsorption, Is the Basic Defect of Cystic Fibrosis Airway Glands

The Journal of biological chemistry, 2006-03, Vol.281 (11), p.7392-7398

2006

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Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis

The Journal of clinical investigation, 2007-10, Vol.117 (10), p.3118-3127

2007

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Variation in CFTR-dependent 'β-sweating' among healthy adults

PloS one, 2022-03, Vol.17 (3), p.e0265432-e0265432

2022

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Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis

The Journal of clinical investigation, 2010-09, Vol.120 (9), p.3149-3160

2010

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Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs

The Journal of clinical investigation, 2010-09, Vol.120 (9), p.3161-3166

2010

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Proteomic analysis of pure human airway gland mucus reveals a large component of protective proteins

PloS one, 2015-02, Vol.10 (2), p.e0116756-e0116756

2015

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Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model

Scientific reports, 2021-09, Vol.11 (1), p.18828-18828, Article 18828

2021

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Acid and base secretion in the Calu-3 model of human serous cells

American journal of physiology. Lung cellular and molecular physiology, 2004-12, Vol.287 (6), p.L1274-L1283

2004

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In vivo readout of CFTR function: ratiometric measurement of CFTR-dependent secretion by individual, identifiable human sweat glands

PloS one, 2013-10, Vol.8 (10), p.e77114

2013

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Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process

The Journal of clinical investigation, 2009-05, Vol.119 (5), p.1189-1200

2009

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Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease

PloS one, 2017, Vol.12 (12), p.e0189894-e0189894

2017

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Submucosal Gland Secretions in Airways from Cystic Fibrosis Patients Have Normal [Na+]and pH but Elevated Viscosity

Proceedings of the National Academy of Sciences - PNAS, 2001-07, Vol.98 (14), p.8119-8123

2001

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Absent Secretion to Vasoactive Intestinal Peptide in Cystic Fibrosis Airway Glands

The Journal of biological chemistry, 2002-12, Vol.277 (52), p.50710-50715

2002

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QUEST FOR CYSTIC FIBROSIS PHARMACOTHERAPY

Clinical and experimental pharmacology & physiology, 2008-08, Vol.35 (8), p.861-862

Soo Joo, Nam

2008

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Regulation of Antiprotease and Antimicrobial Protein Secretion by Airway Submucosal Gland Serous Cells

The Journal of biological chemistry, 2004-09, Vol.279 (37), p.38854-38860

2004

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Variation in CFTR-dependent '[beta]-sweating' among healthy adults

PloS one, 2022-03, Vol.17 (3), p.e0265432

2022

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Optical method for quantifying rates of mucus secretion from single submucosal glands

American journal of physiology. Lung cellular and molecular physiology, 2001-08, Vol.281 (2), p.458-L468

2001

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A "virtual gland" method for quantifying epithelial fluid secretion

American journal of physiology. Lung cellular and molecular physiology, 2004-10, Vol.287 (4), p.L784-L793

2004

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Defective fluid secretion from submucosal glands of nasal turbinates from CFTR-/- and CFTR (ΔF508/ΔF508) pigs

PloS one, 2011, Vol.6 (8), p.e24424

2011

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Progress in understanding mucus abnormalities in cystic fibrosis airways

Journal of cystic fibrosis, 2018-03, Vol.17 (2), p.S35-S39

2018

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Notch signaling inactivation by small molecule γ-secretase inhibitors restores the multiciliated cell population in the airway epithelium

American journal of physiology. Lung cellular and molecular physiology, 2023-06, Vol.324 (6), p.L771-L782

2023

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A virtual gland method for quantifying epithelial fluid secretion

American journal of physiology. Lung cellular and molecular physiology, 2004-10, Vol.31 (4), p.L784-L793

2004

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Marked increases in mucociliary clearance produced by synergistic secretory agonists or inhibition of the epithelial sodium channel

Scientific reports, 2016-11, Vol.6 (1), p.36806-36806, Article 36806

2016

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Defective Fluid Secretion from Submucosal Glands of Nasal Turbinates from CFTR-/- and CFTRΔF508/ΔF508 Pigs

PloS one, 2011-08, Vol.6 (8), p.e24424

2011

Volltextzugriff (PDF)

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Hyposecretion, Not Hyperabsorption, Is the Basic Defect of Cystic Fibrosis Airway Glands

Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis

Variation in CFTR-dependent 'β-sweating' among healthy adults

Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis

Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs

Proteomic analysis of pure human airway gland mucus reveals a large component of protective proteins

Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model

Acid and base secretion in the Calu-3 model of human serous cells

In vivo readout of CFTR function: ratiometric measurement of CFTR-dependent secretion by individual, identifiable human sweat glands

Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process

Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease

Submucosal Gland Secretions in Airways from Cystic Fibrosis Patients Have Normal [Na+]and pH but Elevated Viscosity

Absent Secretion to Vasoactive Intestinal Peptide in Cystic Fibrosis Airway Glands

QUEST FOR CYSTIC FIBROSIS PHARMACOTHERAPY

Regulation of Antiprotease and Antimicrobial Protein Secretion by Airway Submucosal Gland Serous Cells

Variation in CFTR-dependent '[beta]-sweating' among healthy adults

Optical method for quantifying rates of mucus secretion from single submucosal glands

A "virtual gland" method for quantifying epithelial fluid secretion

Defective fluid secretion from submucosal glands of nasal turbinates from CFTR-/- and CFTR (ΔF508/ΔF508) pigs

Progress in understanding mucus abnormalities in cystic fibrosis airways

Notch signaling inactivation by small molecule γ-secretase inhibitors restores the multiciliated cell population in the airway epithelium

Transgenic ferret models define pulmonary ionocyte diversity and function

A virtual gland method for quantifying epithelial fluid secretion

Marked increases in mucociliary clearance produced by synergistic secretory agonists or inhibition of the epithelial sodium channel

Defective Fluid Secretion from Submucosal Glands of Nasal Turbinates from CFTR-/- and CFTRΔF508/ΔF508 Pigs

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