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Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders

Journal of medicinal chemistry, 2018-10, Vol.61 (20), p.9062-9084

2018

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A One-Step Synthesis of 2,4-Unsubstituted Quinoline-3-carboxylic Acid Esters from o-Nitrobenzaldehydes

Journal of organic chemistry, 2010-05, Vol.75 (10), p.3488-3491

2010

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Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1523-1526

2007

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Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines

Journal of medicinal chemistry, 1998-02, Vol.41 (4), p.623-639

1998

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Library Enhancement through the Wisdom of Crowds

Journal of chemical information and modeling, 2011-12, Vol.51 (12), p.3275-3286

2011

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Inhibition of Fructose-1,6-bisphosphatase by a New Class of Allosteric Effectors

The Journal of biological chemistry, 2003-12, Vol.278 (51), p.51176-51183

2003

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Total synthesis of the macrolide antibiotic cytovaricin

Journal of the American Chemical Society, 1990-09, Vol.112 (19), p.7001-7031

1990

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Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: Synthesis and preliminary SAR analysis

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (10), p.2723-2727

2007

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A practical enantioselective synthesis of .alpha.,.alpha.-diaryl-2-pyrrolidinemethanol. Preparation and chemistry of the corresponding oxazaborolidines

Journal of organic chemistry, 1991-01, Vol.56 (2), p.751-762

1991

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Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (10), p.2718-2722

2007

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Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4- f]quinoline derivatives as progesterone receptor modulators

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (12), p.2071-2074

2003

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Design of Concise, Scalable Route to a Cholecystokinin 1 (CCK 1) Receptor Antagonist

Journal of organic chemistry, 2007-10, Vol.72 (22), p.8243-8250

2007

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Discovery and Preliminary SAR Studies of a Novel, Nonsteroidal Progesterone Receptor Antagonist Pharmacophore

Journal of medicinal chemistry, 1998-08, Vol.41 (18), p.3461-3466

1998

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Non-imidazole heterocyclic histamine H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-05, Vol.13 (10), p.1767-1770

2003

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Chemistry of tricarbonyl hemiketals and application of Evans technology to the total synthesis of the immunosuppressant (-)-FK-506

Journal of the American Chemical Society, 1990-04, Vol.112 (8), p.2998-3017

1990

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Novel Series of Potent, Nonsteroidal, Selective Androgen Receptor Modulators Based on 7H-[1,4]Oxazino[3,2-g]quinolin-7-ones

Journal of medicinal chemistry, 2007-05, Vol.50 (10), p.2486-2496

2007

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Preparation, Resolution, and Biological Evaluation of 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines: Potent, Orally Active, Nonsteroidal Progesterone Receptor Agonists

Journal of medicinal chemistry, 1998-07, Vol.41 (15), p.2779-2785

1998

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5-Benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as Selective Progesterone Receptor Modulators

Journal of medicinal chemistry, 2003-09, Vol.46 (19), p.4104-4112

2003

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Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2379-2382

2010

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Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX 2R) antagonists

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (16), p.4225-4229

2004

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Stereoselective Synthesis of Z-α-Aryl-α,β-unsaturated Esters

Journal of organic chemistry, 2006-06, Vol.71 (13), p.5039-5042

2006

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Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2375-2378

2010

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A Scalable Synthesis of a Histamine H3 Receptor Antagonist

Journal of organic chemistry, 2004-11, Vol.69 (23), p.8115-8117

2004

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Total synthesis of immunosuppressant (-)-FK-506

Journal of the American Chemical Society, 1989-02, Vol.111 (3), p.1157-1159

1989

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Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: Part 1

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2370-2374

2010

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Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders

A One-Step Synthesis of 2,4-Unsubstituted Quinoline-3-carboxylic Acid Esters from o-Nitrobenzaldehydes

Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones

Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines

Library Enhancement through the Wisdom of Crowds

Inhibition of Fructose-1,6-bisphosphatase by a New Class of Allosteric Effectors

Total synthesis of the macrolide antibiotic cytovaricin

Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: Synthesis and preliminary SAR analysis

A practical enantioselective synthesis of .alpha.,.alpha.-diaryl-2-pyrrolidinemethanol. Preparation and chemistry of the corresponding oxazaborolidines

Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains

Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4- f]quinoline derivatives as progesterone receptor modulators

Design of Concise, Scalable Route to a Cholecystokinin 1 (CCK 1) Receptor Antagonist

Discovery and Preliminary SAR Studies of a Novel, Nonsteroidal Progesterone Receptor Antagonist Pharmacophore

Non-imidazole heterocyclic histamine H3 receptor antagonists

Chemistry of tricarbonyl hemiketals and application of Evans technology to the total synthesis of the immunosuppressant (-)-FK-506

Novel Series of Potent, Nonsteroidal, Selective Androgen Receptor Modulators Based on 7H-[1,4]Oxazino[3,2-g]quinolin-7-ones

Preparation, Resolution, and Biological Evaluation of 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines: Potent, Orally Active, Nonsteroidal Progesterone Receptor Agonists

5-Benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as Selective Progesterone Receptor Modulators

Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors

Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX 2R) antagonists

Stereoselective Synthesis of Z-α-Aryl-α,β-unsaturated Esters

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions

A Scalable Synthesis of a Histamine H3 Receptor Antagonist

Total synthesis of immunosuppressant (-)-FK-506

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: Part 1

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