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Assessment of Mycobacterium tuberculosis Pantothenate Kinase Vulnerability through Target Knockdown and Mechanistically Diverse Inhibitors

Antimicrobial agents and chemotherapy, 2014-06, Vol.58 (6), p.3312-3326

2014

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The Missing Piece of the Type II Fatty Acid Synthase System from Mycobacterium tuberculosis

Proceedings of the National Academy of Sciences - PNAS, 2007-09, Vol.104 (37), p.14628-14633

2007

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Structure and Function of Carbonic Anhydrases from Mycobacterium tuberculosis

The Journal of biological chemistry, 2005-05, Vol.280 (19), p.18782-18789

2005

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Moth Chemosensory Protein Exhibits Drastic Conformational Changes and Cooperativity on Ligand Binding

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (9), p.5069-5074

2003

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X-ray Structure and Ligand Binding Study of a Moth Chemosensory Protein

The Journal of biological chemistry, 2002-08, Vol.277 (35), p.32094-32098

2002

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Structures of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Provide New Insights into Catalysis

The Journal of biological chemistry, 2007-07, Vol.282 (27), p.19905-19916

2007

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Crystal Structures of a Poplar Xyloglucan Endotransglycosylase Reveal Details of Transglycosylation Acceptor Binding

The Plant cell, 2004-04, Vol.16 (4), p.874-886

2004

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Structure of Mycobacterium tuberculosis Glutamine Synthetase in Complex with a Transition-State Mimic Provides Functional Insights

Proceedings of the National Academy of Sciences - PNAS, 2005-07, Vol.102 (30), p.10499-10504

2005

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Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme

Open biology, 2012-01, Vol.2 (1), p.110026-110026

2012

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[27] Detecting folding motifs and similarities in protein structures

Methods in Enzymology, 1997, Vol.277, p.525-545

1997

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Structure of the methyltransferase domain from the Modoc virus, a flavivirus with no known vector

Acta crystallographica. Section D, Biological crystallography., 2009-08, Vol.65 (8), p.796-803

2009

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Structure of Aspergillus niger epoxide hydrolase at 1.8 Å resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases

Structure (London), 2000-02, Vol.8 (2), p.111-122

2000

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Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

European journal of medicinal chemistry, 2024, Vol.278, p.116790, Article 116790

2024

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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Proceedings of the National Academy of Sciences - PNAS, 2024-04, Vol.121 (15), p.e2317274121

2024

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Structural and Biochemical Characterization of Compounds Inhibiting Mycobacterium tuberculosis Pantothenate Kinase

The Journal of biological chemistry, 2013-06, Vol.288 (25), p.18260-18270

2013

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Structural, Biochemical, and In Vivo Investigations of the Threonine Synthase from Mycobacterium tuberculosis

Journal of molecular biology, 2008-09, Vol.381 (3), p.622-633

2008

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Comparison of family 12 glycoside hydrolases and recruited substitutions important for thermal stability

Protein science, 2003-04, Vol.12 (4), p.848-860

2003

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Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active β-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6649-6654

2009

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Structure and function of Rv0130, a conserved hypothetical protein from Mycobacterium tuberculosis

Protein science, 2006-10, Vol.15 (10), p.2300-2309

2006

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The Uppsala Electron-Density Server

Acta crystallographica. Section D, Biological crystallography., 2004-12, Vol.60 (12-1), p.2240-2249

2004

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Interactive electron-density map interpretation: from INTER to O

Acta crystallographica. Section D, Biological crystallography., 2004-12, Vol.60 (12-1), p.2115-2125

Jones, T. Alwyn

2004

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The Telltale Structures of Epoxide Hydrolases

Drug metabolism reviews, 2003-01, Vol.35 (4), p.365-383

2003

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Structural Mechanics of the pH-dependent Activity of β-Carbonic Anhydrase from Mycobacterium tuberculosis

The Journal of biological chemistry, 2006-02, Vol.281 (8), p.4993-4999

2006

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Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design

Journal of molecular biology, 2008-01, Vol.375 (1), p.217-228

2008

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Design, Synthesis, and X-ray Crystallographic Studies of α-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase

Journal of medicinal chemistry, 2011-07, Vol.54 (14), p.4964-4976

2011

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Assessment of Mycobacterium tuberculosis Pantothenate Kinase Vulnerability through Target Knockdown and Mechanistically Diverse Inhibitors

The Missing Piece of the Type II Fatty Acid Synthase System from Mycobacterium tuberculosis

Structure and Function of Carbonic Anhydrases from Mycobacterium tuberculosis

Moth Chemosensory Protein Exhibits Drastic Conformational Changes and Cooperativity on Ligand Binding

X-ray Structure and Ligand Binding Study of a Moth Chemosensory Protein

Structures of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Provide New Insights into Catalysis

Crystal Structures of a Poplar Xyloglucan Endotransglycosylase Reveal Details of Transglycosylation Acceptor Binding

Structure of Mycobacterium tuberculosis Glutamine Synthetase in Complex with a Transition-State Mimic Provides Functional Insights

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme

[27] Detecting folding motifs and similarities in protein structures

Structure of the methyltransferase domain from the Modoc virus, a flavivirus with no known vector

Structure of Aspergillus niger epoxide hydrolase at 1.8 Å resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases

Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Structural and Biochemical Characterization of Compounds Inhibiting Mycobacterium tuberculosis Pantothenate Kinase

Structural, Biochemical, and In Vivo Investigations of the Threonine Synthase from Mycobacterium tuberculosis

Comparison of family 12 glycoside hydrolases and recruited substitutions important for thermal stability

Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active β-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c

Structure and function of Rv0130, a conserved hypothetical protein from Mycobacterium tuberculosis

The Uppsala Electron-Density Server

Interactive electron-density map interpretation: from INTER to O

The Telltale Structures of Epoxide Hydrolases

Structural Mechanics of the pH-dependent Activity of β-Carbonic Anhydrase from Mycobacterium tuberculosis

Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design

Design, Synthesis, and X-ray Crystallographic Studies of α-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase

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