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Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma

Blood, 2019-04, Vol.133 (14), p.1572-1584

2019

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Intravenous Immunoglobulin G (IVIg) Suppresses HSP70-1 and Has Potential Therapeutic Effects Against Multiple Myeloma and Lymphoma

Blood, 2013-11, Vol.122 (21), p.3845-3845

2013

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Drug Resistance to the HDM-2 Inhibitors MI-63 and Nutlin Is Mediated by Point Mutations of p53, but Can Be Overcome with the p53 Targeting Agent RITA

Blood, 2011-11, Vol.118 (21), p.2726-2726

2011

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Exosome targeted therapy—a step in the future

Translational cancer research, 2017-12, Vol.6 (S9), p.S1398-S1401

2017

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Thalidomide, Lenalidomide and Pomalidomide Disrupt Epstein-Barr Virus (EBV) Latency: Clinical Implications

Blood, 2013-11, Vol.122 (21), p.3499-3499

2013

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The Anti-Tumor Effect of the Ubiquitin-Activating Enzyme (UAE) Inhibitor TAK-243 on Pre-Clinical Models of Multiple Myeloma

Blood, 2016-12, Vol.128 (22), p.3296-3296

2016

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RNA Polymerase I Inhibition with CX-5461 As a Novel Strategy to Target MYC in Multiple Myeloma

Blood, 2015-12, Vol.126 (23), p.3010-3010

2015

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Inhibition of the HDM-2 E3 Ligase Induces Types I and II Cell Death in Wild-Type and Mutant p53 Models of Multiple Myeloma, and Acts Synergistically in Both with ABT-737

Blood, 2012-11, Vol.120 (21), p.2940-2940

2012

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CX-5461, a Novel RNA Polymerase I Inhibitor, Is Active Against Wild-Type and Mutant p53 Myeloma Models

Blood, 2013-11, Vol.122 (21), p.4438-4438

2013

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Blockade of IGF-1R with OSI-906 Overcomes Bortezomib-Resistance in Multiple Myeloma

Blood, 2011-11, Vol.118 (21), p.925-925

2011

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Inhibition of the Human Double Minute (HDM)-2 E3 Ubiquitin Ligase Activates Different Programmed Cell Death (PCD) Pathways in Models of Non-Hodgkin Lymphoma (NHL) with Wild Type (wt) and Mutant (mut) p53

Blood, 2008-11, Vol.112 (11), p.3618-3618

2008

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The baltic countries: from economic stabilization to EU accession.

1998

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Classification of Intrinsically Disordered Regions and Proteins

Chemical reviews, 2014-07, Vol.114 (13), p.6589-6631

2014

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Conservative versus Interventional Treatment for Spontaneous Pneumothorax

The New England journal of medicine, 2020-01, Vol.382 (5), p.405-415

2020

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Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis

Nature (London), 2016-06, Vol.534 (7605), p.124-128

2016

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Controlling particle size in the Stöber process and incorporation of calcium

Journal of colloid and interface science, 2016-05, Vol.469, p.213-223

2016

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Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11004-11018

2019

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Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point

Journal of medicinal chemistry, 2017-04, Vol.60 (8), p.3438-3450

2017

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Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis

Gut microbes, 2023-12, Vol.15 (1), p.2208501-2208501

2023

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Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

Cancer cell, 2017-08, Vol.32 (2), p.204-220.e15

2017

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Mild encephalitis/encephalopathy with reversible splenial lesion in association with Staphylococcus aureus bacteraemia

Journal of paediatrics and child health, 2022-05, Vol.58 (5), p.913-917

2022

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Risk factors for SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study

The Lancet infectious diseases, 2020-09, Vol.20 (9), p.1034-1042

2020

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A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants

Journal of materials science. Materials in medicine, 2015-02, Vol.26 (2), p.115-10, Article 115

2015

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Regional climate models downscaling analysis of general circulation models present climate biases propagation into future change projections

Geophysical research letters, 2008-04, Vol.35 (8), p.L08709-n/a

2008

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Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma

Intravenous Immunoglobulin G (IVIg) Suppresses HSP70-1 and Has Potential Therapeutic Effects Against Multiple Myeloma and Lymphoma

Drug Resistance to the HDM-2 Inhibitors MI-63 and Nutlin Is Mediated by Point Mutations of p53, but Can Be Overcome with the p53 Targeting Agent RITA

Exosome targeted therapy—a step in the future

Thalidomide, Lenalidomide and Pomalidomide Disrupt Epstein-Barr Virus (EBV) Latency: Clinical Implications

The Anti-Tumor Effect of the Ubiquitin-Activating Enzyme (UAE) Inhibitor TAK-243 on Pre-Clinical Models of Multiple Myeloma

RNA Polymerase I Inhibition with CX-5461 As a Novel Strategy to Target MYC in Multiple Myeloma

Inhibition of the HDM-2 E3 Ligase Induces Types I and II Cell Death in Wild-Type and Mutant p53 Models of Multiple Myeloma, and Acts Synergistically in Both with ABT-737

CX-5461, a Novel RNA Polymerase I Inhibitor, Is Active Against Wild-Type and Mutant p53 Myeloma Models

Blockade of IGF-1R with OSI-906 Overcomes Bortezomib-Resistance in Multiple Myeloma

Inhibition of the Human Double Minute (HDM)-2 E3 Ubiquitin Ligase Activates Different Programmed Cell Death (PCD) Pathways in Models of Non-Hodgkin Lymphoma (NHL) with Wild Type (wt) and Mutant (mut) p53

The baltic countries: from economic stabilization to EU accession.

Classification of Intrinsically Disordered Regions and Proteins

Conservative versus Interventional Treatment for Spontaneous Pneumothorax

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis

Controlling particle size in the Stöber process and incorporation of calcium

Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)

Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point

Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

Mild encephalitis/encephalopathy with reversible splenial lesion in association with Staphylococcus aureus bacteraemia

Risk factors for SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study

Bayesian refinement of association signals for 14 loci in 3 common diseases

A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants

Regional climate models downscaling analysis of general circulation models present climate biases propagation into future change projections

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