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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.761-764

2005

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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

Biochemical journal, 2005-01, Vol.385 (Pt 2), p.399-408

2005

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Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

Molecular cancer therapeutics, 2005-02, Vol.4 (2), p.271-279

2005

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Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.905-909

2005

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A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo

Nature medicine, 2000-11, Vol.6 (11), p.1248-1252

2000

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Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3178-3182

2008

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Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.834-836

2009

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A Prostate-specific Antigen (PSA)-activated Vinblastine Prodrug Selectively Kills PSA-secreting Cells in Vivo

Molecular cancer therapeutics, 2002-05, Vol.1 (7), p.451

2002

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Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity

Bioorganic & medicinal chemistry, 2008, Vol.18 (1), p.49-53

2008

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Rapid assembly of diverse and potent allosteric Akt inhibitors

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.2211-2214

2008

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The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4191-4194

2008

Volltextzugriff (PDF)

Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.2194-2197

2008

Volltextzugriff (PDF)

The Synthesis of a Prodrug of Doxorubicin Designed to Provide Reduced Systemic Toxicity and Greater Target Efficacy

Journal of medicinal chemistry, 2001-11, Vol.44 (24), p.4216-4224

2001

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Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4186-4190

2008

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Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (4), p.1274-1279

2008

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PSA-specific and non-PSA-specific conversion of a PSA-targeted peptide conjugate of doxorubicin to its active metabolites

Drug metabolism and disposition, 2001-03, Vol.29 (3), p.313

2001

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Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

Nature (London), 1991-07, Vol.352 (6332), p.251-254

1991

Volltextzugriff (PDF)

Beyond Window-Dressing? Canadian Children's Fantasy at the Millennium (review)

Children's Literature Association Quarterly, 2008-12, Vol.33 (4), p.448-451

Jones, Raymond E

2008

Volltextzugriff (PDF)

'Different Moments in the One Cycle': Alchemical and Blakean Symbolism in Michael Bedard's Redwork

Children's Literature Association Quarterly, 1995-03, Vol.20 (1), p.3-8

Jones, Raymond E

1995

Volltextzugriff (PDF)

Allosteric inhibitors of Aktl and Akt2 : Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (3), p.834-836

2009

Volltextzugriff (PDF)

The Intimate Life of L. M. Montgomery (review)

Children's Literature Association Quarterly, 2005-12, Vol.30 (4), p.437-440

Jones, Raymond E

2005

Volltextzugriff (PDF)

Expression and secretion in yeast of a 400-kda envelope glycoprotein derived from epstein-barr virus

Gene, 1987, Vol.54 (1), p.113-123

1987

Volltextzugriff (PDF)

Windows and Words: A Look at Canadian Children's Literature in English (review)

Children's Literature Association Quarterly, 2005-07, Vol.30 (2), p.229-232

Jones, Raymond E

2005

Volltextzugriff (PDF)

Characterization of the retinoblastoma binding proteins RBP1 and RBP2

Oncogene, 1993-11, Vol.8 (11), p.3149-3156

1993

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Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides

Molecular and Cellular Biology, 1991-11, Vol.11 (11), p.5792-5799

1991

Volltextzugriff (PDF)

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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo

Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model

Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

A Prostate-specific Antigen (PSA)-activated Vinblastine Prodrug Selectively Kills PSA-secreting Cells in Vivo

Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity

Rapid assembly of diverse and potent allosteric Akt inhibitors

The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity

Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors

The Synthesis of a Prodrug of Doxorubicin Designed to Provide Reduced Systemic Toxicity and Greater Target Efficacy

Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors

Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors

PSA-specific and non-PSA-specific conversion of a PSA-targeted peptide conjugate of doxorubicin to its active metabolites

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

Beyond Window-Dressing? Canadian Children's Fantasy at the Millennium (review)

'Different Moments in the One Cycle': Alchemical and Blakean Symbolism in Michael Bedard's Redwork

Allosteric inhibitors of Aktl and Akt2 : Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

The Intimate Life of L. M. Montgomery (review)

Expression and secretion in yeast of a 400-kda envelope glycoprotein derived from epstein-barr virus

Windows and Words: A Look at Canadian Children's Literature in English (review)

Characterization of the retinoblastoma binding proteins RBP1 and RBP2

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides

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