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Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

Scientific reports, 2023-11, Vol.13 (1), p.19052-19052, Article 19052

2023

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GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain

ACS medicinal chemistry letters, 2016-06, Vol.7 (6), p.552-557

2016

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A kinetic intra-cellular assay (KICA) to measure quantitative compound binding kinetics within living cells

STAR protocols, 2022-03, Vol.3 (1), p.101078-101078, Article 101078

2022

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Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins

Journal of medicinal chemistry, 2020-09, Vol.63 (17), p.9070-9092

2020

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Development of an intracellular quantitative assay to measure compound binding kinetics

Cell chemical biology, 2023-12, Vol.30 (12), p.1692-1692

2023

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Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors

Journal of medicinal chemistry, 2015-08, Vol.58 (15), p.6151-6178

2015

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Development of an intracellular quantitative assay to measure compound binding kinetics

Cell chemical biology, 2022-02, Vol.29 (2), p.287-299.e8

2022

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Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors

Journal of medicinal chemistry, 2015-07, Vol.58 (14), p.5649-5673

2015

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A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification

Journal of medicinal chemistry, 2019-08, Vol.62 (16), p.7506-7525

2019

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1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

ACS medicinal chemistry letters, 2014-11, Vol.5 (11), p.1190-1195

2014

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Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions

SLAS discovery, 2020-02, Vol.25 (2), p.163-175

2020

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1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (8), p.2230-2234

2009

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Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

Journal of medicinal chemistry, 2011-06, Vol.54 (11), p.3827-3838

2011

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Identification, Cloning, and Expression of a Functional Phenylalanyl-tRNA Synthetase (pheRS) from Staphylococcus aureus

Protein expression and purification, 2001-04, Vol.21 (3), p.470-484

2001

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Management of the Sick Infant

The American Journal of Nursing, 1924, Vol.24 (9), p.783-783

1924

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Management of the Sick Infant

The American journal of nursing, 1924-06, Vol.24 (9), p.783

1924

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Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response

British journal of cancer, 2021-12, Vol.125 (12), p.1666-1676

2021

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Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

PLoS biology, 2015-12, Vol.13 (12), p.e1002309-e1002309

2015

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Dual role of USP30 in controlling basal pexophagy and mitophagy

EMBO reports, 2018-07, Vol.19 (7), p.n/a

2018

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ELF3 Controls Thermoresponsive Growth in Arabidopsis

Current biology, 2015-01, Vol.25 (2), p.194-199

2015

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Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

Nature communications, 2021-02, Vol.12 (1), p.1209-13, Article 1209

2021

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The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

Immunity (Cambridge, Mass.), 2015-01, Vol.42 (1), p.41-54

2015

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Interfamily transfer of a plant pattern-recognition receptor confers broad-spectrum bacterial resistance

Nature biotechnology, 2010-04, Vol.28 (4), p.365-369

2010

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Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

Cell metabolism, 2016-07, Vol.24 (1), p.158-166

2016

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Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain

A kinetic intra-cellular assay (KICA) to measure quantitative compound binding kinetics within living cells

Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins

Development of an intracellular quantitative assay to measure compound binding kinetics

Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors

Development of an intracellular quantitative assay to measure compound binding kinetics

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors

A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions

1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3

Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

Identification, Cloning, and Expression of a Functional Phenylalanyl-tRNA Synthetase (pheRS) from Staphylococcus aureus

Management of the Sick Infant

Management of the Sick Infant

Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

Dual role of USP30 in controlling basal pexophagy and mitophagy

ELF3 Controls Thermoresponsive Growth in Arabidopsis

Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

Interfamily transfer of a plant pattern-recognition receptor confers broad-spectrum bacterial resistance

Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

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