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Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog

The Journal of biological chemistry, 2013-05, Vol.288 (21), p.15256-15267

2013

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Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

PLoS neglected tropical diseases, 2015-12, Vol.9 (12), p.e0004299-e0004299

2015

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Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

Molecular microbiology, 2012-10, Vol.86 (1), p.51-64

2012

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Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

ChemMedChem, 2009-08, Vol.4 (8), p.1333-1340

2009

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Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

ChemMedChem, 2009-08, Vol.4 (8), p.1341-1353

2009

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Trypanosoma brucei UDP-Glucose:Glycoprotein Glucosyltransferase Has Unusual Substrate Specificity and Protects the Parasite from Stress

Eukaryotic Cell, 2009-02, Vol.8 (2), p.230-240

2009

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Deletion of the Glucosidase II Gene in Trypanosoma brucei Reveals Novel N-Glycosylation Mechanisms in the Biosynthesis of Variant Surface Glycoprotein

The Journal of biological chemistry, 2005-10, Vol.280 (43), p.35929-35942

2005

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Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

Journal of medicinal chemistry, 2011-10, Vol.54 (19), p.6514-6530

2011

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Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

Biochemical pharmacology, 2010-11, Vol.80 (10), p.1478-1486

2010

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Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity

Bioorganic & medicinal chemistry, 2015-08, Vol.23 (16), p.5156-5167

2015

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Development of a Novel Virtual Screening Cascade Protocol to Identify Potential Trypanothione Reductase Inhibitors

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1670-1680

2009

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Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi

Molecular and biochemical parasitology, 2010-01, Vol.169 (1), p.12-19

2010

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High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (5), p.1280-1283

2007

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Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase

ChemMedChem, 2011-02, Vol.6 (2), p.321-328

2011

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Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome: e0004299

PLoS neglected tropical diseases, 2015-12, Vol.9 (12)

2015

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Cover Picture: Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis / Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase (ChemMedChem 8/2009)

ChemMedChem, 2009-08, Vol.4 (8), p.1209-1209

2009

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Cover Picture: Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 / Modified 5′-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase (ChemMedChem 2/2011)

ChemMedChem, 2011-02, Vol.6 (2), p.209-209

2011

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Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

Trypanosoma brucei UDP-Glucose:Glycoprotein Glucosyltransferase Has Unusual Substrate Specificity and Protects the Parasite from Stress

Deletion of the Glucosidase II Gene in Trypanosoma brucei Reveals Novel N-Glycosylation Mechanisms in the Biosynthesis of Variant Surface Glycoprotein

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity

Development of a Novel Virtual Screening Cascade Protocol to Identify Potential Trypanothione Reductase Inhibitors

Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi

High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity

Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome: e0004299

Cover Picture: Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis / Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase (ChemMedChem 8/2009)

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