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Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators

Journal of the American Chemical Society, 2016-06, Vol.138 (21), p.6754-6764

2016

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Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

Nature communications, 2017-10, Vol.8 (1), p.1-11, Article 763

2017

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Single-molecule analysis of ligand efficacy in β2AR–G-protein activation

Nature (London), 2017-07, Vol.547 (7661), p.68-73

2017

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Roles of the Akt/GSK-3 and Wnt Signaling Pathways in Schizophrenia and Antipsychotic Drug Action

American Journal of Psychiatry, 2010-04, Vol.167 (4), p.388-396

2010

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The role of kinetic context in apparent biased agonism at GPCRs

Nature communications, 2016-02, Vol.7 (1), p.10842-10842, Article 10842

2016

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CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out

The Journal of physiology, 2014-06, Vol.592 (12), p.2443-2445

2014

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The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na + and Substrate Is Triggered by Substrate in a Second Binding Site

Molecular cell, 2008-06, Vol.30 (6), p.667-677

2008

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Potentiating SLC transporter activity: Emerging drug discovery opportunities

Biochemical pharmacology, 2017-07, Vol.135, p.1-11

2017

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Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum

Nature communications, 2018-03, Vol.9 (1), p.1086-13, Article 1086

2018

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What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?

Pharmacological reviews, 2015-01, Vol.67 (1), p.198-213

2015

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Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

Nature Chemical Biology, 2009-09, Vol.5 (9), p.688-695

2009

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Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer

Nature communications, 2024-10, Vol.15 (1), p.8552-15, Article 8552

2024

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Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor

Journal of the American Chemical Society, 2019-07, Vol.141 (29), p.11522-11530

2019

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Single-molecule dynamics of gating in a neurotransmitter transporter homologue

Nature (London), 2010-05, Vol.465 (7295), p.188-193

2010

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Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain

Neuropsychopharmacology (New York, N.Y.), 2023-10, Vol.48 (11), p.1680-1689

2023

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The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter

PloS one, 2011-01, Vol.6 (1), p.e16350-e16350

2011

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Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist

Journal of the American Chemical Society, 2017-12, Vol.139 (51), p.18522-18535

2017

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Dopamine D2 receptors form higher order oligomers at physiological expression levels

The EMBO journal, 2008-09, Vol.27 (17), p.2293-2304

2008

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Monitoring the function of membrane transport proteins in detergent-solubilized form

Proceedings of the National Academy of Sciences - PNAS, 2007-02, Vol.104 (9), p.3603-3608

2007

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Conformational dynamics of ligand-dependent alternating access in LeuT

Nature structural & molecular biology, 2014-05, Vol.21 (5), p.472-479

2014

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Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder

Nature communications, 2021-09, Vol.12 (1), p.4087-4087, Article 4087

2021

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Structure of human GABAB receptor in an inactive state

Nature (London), 2020-08, Vol.584 (7820), p.304-309

2020

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Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

Nature (London), 2011-06, Vol.474 (7349), p.109-113

2011

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Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence

Frontiers in pharmacology, 2019-04, Vol.10, p.350-350

2019

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Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum

BioTechniques, 2011-08, Vol.51 (2), p.111-118

2011

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Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

Single-molecule analysis of ligand efficacy in β2AR–G-protein activation

Roles of the Akt/GSK-3 and Wnt Signaling Pathways in Schizophrenia and Antipsychotic Drug Action

The role of kinetic context in apparent biased agonism at GPCRs

CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out

The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na + and Substrate Is Triggered by Substrate in a Second Binding Site

Potentiating SLC transporter activity: Emerging drug discovery opportunities

Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum

What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer

Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain

The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist

Dopamine D2 receptors form higher order oligomers at physiological expression levels

Monitoring the function of membrane transport proteins in detergent-solubilized form

Conformational dynamics of ligand-dependent alternating access in LeuT

Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder

Structure of human GABAB receptor in an inactive state

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence

Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum

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