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Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

Nature biotechnology, 2015-07, Vol.33 (7), p.733-735

2015

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Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models

Cancer research (Chicago, Ill.), 2016-05, Vol.76 (9), p.2710-2719

2016

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Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody-Drug Conjugates

Molecular cancer therapeutics, 2017-07, Vol.16 (7), p.1347-1354

2017

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A Role for Cysteinyl Leukotrienes in Airway Remodeling in a Mouse Asthma Model

American journal of respiratory and critical care medicine, 2002-01, Vol.165 (1), p.108-116

2002

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Characterization of SGN-CD123A, A Potent CD123-Directed Antibody-Drug Conjugate for Acute Myeloid Leukemia

Molecular cancer therapeutics, 2018-02, Vol.17 (2), p.554-564

2018

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Neutrophil apoptosis in the acute respiratory distress syndrome

American journal of respiratory and critical care medicine, 1997-12, Vol.156 (6), p.1969-1977

1997

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Anti-leukemic activity of Lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia

mAbs, 2009-09, Vol.1 (5), p.481-490

2009

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Brentuximab Vedotin-Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity

Molecular cancer therapeutics, 2024-01, Vol.23 (1), p.68

2024

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Abstract 2906: SGN-B6A: A new MMAE ADC targeting integrin beta-6 in multiple carcinoma indications

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2906-2906

2020

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Characterization of Group B Streptococcal Invasion of Human Chorion and Amnion Epithelial Cells In Vitro

Infection and Immunity, 1998-10, Vol.66 (10), p.4932-4941

1998

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Abstract 351: Uptake of antibody-drug conjugates by cultured Kupffer cells can predict pharmacokinetics

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.351-351

2016

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An in Vitro Assay Using Cultured Kupffer Cells Can Predict the Impact of Drug Conjugation on in Vivo Antibody Pharmacokinetics

Molecular pharmaceutics, 2020-03, Vol.17 (3), p.802-809

2020

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Abstract 1686: CD70 as a target in non-Hodgkin lymphoma (NHL) and renal cell carcinoma (RCC)

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.1686-1686

2015

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Abstract 5507: Characterization of ADC bystander killing in admixed tumor model

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5507-5507

2015

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Abstract 1285: Tumor associated macrophages can process antibody-drug conjugates and contribute to antitumor activity in preclinical xenograft models

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1285-1285

2016

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A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model

American journal of respiratory and critical care medicine, 2002-01, Vol.165 (1), p.108

2002

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Abstract 1195: SGN-CD352A: A novel humanized anti-CD352 antibody-drug conjugate for the treatment of multiple myeloma

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1195-1195

2016

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SGN-CD123A, a Pyrrolobenzodiazepine Dimer Linked Anti-CD123 Antibody Drug Conjugate, Demonstrates Effective Anti-Leukemic Activity in Multiple Preclinical Models of AML

Blood, 2015-12, Vol.126 (23), p.330-330

2015

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Abstract 2890: Mechanistic evaluation of the anti-tumor activities of 2-fluorofucose alone and in combination with anti-idiotype vaccination

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.2890-2890

2014

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Abstract 3694: Relationship between in vivo antitumor activity of ADC and payload release in preclinical models

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.3694-3694

2014

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Abstract 2647: SGN-CD70A, a novel and highly potent anti-CD70 ADC, induces double-strand DNA breaks and is active in models of MDR+ renal cell carcinoma (RCC) and non-Hodgkin lymphoma (NHL)

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.2647-2647

2014

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Fas (CD95) Induces Alveolar Epithelial Cell Apoptosis in Vivo : Implications for Acute Pulmonary Inflammation

The American journal of pathology, 2001-01, Vol.158 (1), p.153-161

2001

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Soluble Fas Ligand Induces Epithelial Cell Apoptosis in Humans with Acute Lung Injury (ARDS)

The Journal of immunology (1950), 1999-08, Vol.163 (4), p.2217-2225

1999

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Abstract 4630: Integrin αVα6 is expressed on multiple solid tumors and is a potential therapeutic target for auristatin-based antibody-drug conjugates

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.4630-4630

2012

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Translocation of the 85-kDa Phospholipase A from Cytosol to the Nuclear Envelope in Rat Basophilic Leukemia Cells Stimulated with Calcium Ionophore or IgE/Antigen

The Journal of biological chemistry, 1995-06, Vol.270 (25), p.15359

1995

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Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models

Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody-Drug Conjugates

A Role for Cysteinyl Leukotrienes in Airway Remodeling in a Mouse Asthma Model

Characterization of SGN-CD123A, A Potent CD123-Directed Antibody-Drug Conjugate for Acute Myeloid Leukemia

Neutrophil apoptosis in the acute respiratory distress syndrome

Anti-leukemic activity of Lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia

Brentuximab Vedotin-Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity

Abstract 2906: SGN-B6A: A new MMAE ADC targeting integrin beta-6 in multiple carcinoma indications

Characterization of Group B Streptococcal Invasion of Human Chorion and Amnion Epithelial Cells In Vitro

Abstract 351: Uptake of antibody-drug conjugates by cultured Kupffer cells can predict pharmacokinetics

An in Vitro Assay Using Cultured Kupffer Cells Can Predict the Impact of Drug Conjugation on in Vivo Antibody Pharmacokinetics

Abstract 1686: CD70 as a target in non-Hodgkin lymphoma (NHL) and renal cell carcinoma (RCC)

Abstract 5507: Characterization of ADC bystander killing in admixed tumor model

Abstract 1285: Tumor associated macrophages can process antibody-drug conjugates and contribute to antitumor activity in preclinical xenograft models

A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model

Abstract 1195: SGN-CD352A: A novel humanized anti-CD352 antibody-drug conjugate for the treatment of multiple myeloma

SGN-CD123A, a Pyrrolobenzodiazepine Dimer Linked Anti-CD123 Antibody Drug Conjugate, Demonstrates Effective Anti-Leukemic Activity in Multiple Preclinical Models of AML

Abstract 2890: Mechanistic evaluation of the anti-tumor activities of 2-fluorofucose alone and in combination with anti-idiotype vaccination

Abstract 3694: Relationship between in vivo antitumor activity of ADC and payload release in preclinical models

Abstract 2647: SGN-CD70A, a novel and highly potent anti-CD70 ADC, induces double-strand DNA breaks and is active in models of MDR+ renal cell carcinoma (RCC) and non-Hodgkin lymphoma (NHL)

Fas (CD95) Induces Alveolar Epithelial Cell Apoptosis in Vivo : Implications for Acute Pulmonary Inflammation

Soluble Fas Ligand Induces Epithelial Cell Apoptosis in Humans with Acute Lung Injury (ARDS)

Abstract 4630: Integrin αVα6 is expressed on multiple solid tumors and is a potential therapeutic target for auristatin-based antibody-drug conjugates

Translocation of the 85-kDa Phospholipase A from Cytosol to the Nuclear Envelope in Rat Basophilic Leukemia Cells Stimulated with Calcium Ionophore or IgE/Antigen

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