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Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

Journal of endocrinology, 2018-02, Vol.236 (2), p.R109-R143

2018

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Aspalathin Protects Insulin‐Producing β Cells against Glucotoxicity and Oxidative Stress‐Induced Cell Death

Molecular nutrition & food research, 2020-04, Vol.64 (8), p.e1901009-n/a

2020

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Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans

Diabetologia, 2019-12, Vol.62 (12), p.2273-2286

2019

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Transcriptome analysis of islets from diabetes‐resistant and diabetes‐prone obese mice reveals novel gene regulatory networks involved in beta‐cell compensation and failure

The FASEB journal, 2021-06, Vol.35 (6), p.e21608-n/a

2021

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Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells

Diabetologia, 2016-07, Vol.59 (7), p.1492-1502

2016

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Phlda3 regulates beta cell survival during stress

Scientific reports, 2019-09, Vol.9 (1), p.12827-13, Article 12827

2019

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Somatostatin Is Only Partly Required for the Glucagonostatic Effect of Glucose but Is Necessary for the Glucagonostatic Effect of KATP Channel Blockers

Diabetes (New York, N.Y.), 2018-11, Vol.67 (11), p.2239-2253

2018

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Protective antioxidant and antiapoptotic effects of ZnCl2 in rat pancreatic islets cultured in low and high glucose concentrations

PloS one, 2012-10, Vol.7 (10), p.e46831

2012

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Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and Above Metal Homeostasis and Antioxidant Response

Biology (Basel, Switzerland), 2021-02, Vol.10 (3), p.176

2021

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Nutrient Metabolism, Subcellular Redox State, and Oxidative Stress in Pancreatic Islets and β-Cells

Journal of molecular biology, 2020-03, Vol.432 (5), p.1461-1493

2020

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The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes

PloS one, 2014-02, Vol.9 (2), p.e87941-e87941

2014

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Proof-of-concept for 2D/CT element analysis of entire cryofrozen islets of Langerhans using a cryoloop synchrotron X-ray fluorescence setup

Journal of analytical atomic spectrometry, 2020-07, Vol.35 (7), p.1368-1379

2020

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Glucokinase activation is beneficial or toxic to cultured rat pancreatic islets depending on the prevailing glucose concentration

American journal of physiology: endocrinology and metabolism, 2015-10, Vol.309 (7), p.E632-E639

2015

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The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions

Molecular and cellular endocrinology, 2012-11, Vol.364 (1-2), p.1-27

2012

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Role of activating transcription factor 3 in low glucose- and thapsigargin-induced apoptosis in cultured mouse islets

Biochemical and biophysical research communications, 2011-11, Vol.415 (2), p.294-299

2011

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NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

Molecular metabolism (Germany), 2017-06, Vol.6 (6), p.535-547

2017

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In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

Frontiers in cell and developmental biology, 2022-08, Vol.10, p.967765-967765

2022

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Signals and Pools Underlying Biphasic Insulin Secretion

Diabetes (New York, N.Y.), 2002-02, Vol.51 (suppl 1), p.S60-S67

2002

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The lack of functional nicotinamide nucleotide transhydrogenase only moderately contributes to the impairment of glucose tolerance and glucose-stimulated insulin secretion in C57BL/6J vs C57BL/6N mice

Diabetologia, 2021-11, Vol.64 (11), p.2550-2561

2021

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Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes : Many differences, few similarities

Diabetes (New York, N.Y.), 2005-12, Vol.54 (12), p.S97-S107

2005

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Editorial Overview: “Islet Biology in Type 2 Diabetes”

Journal of molecular biology, 2020-03, Vol.432 (5), p.1307-1309

2020

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Control Mechanisms of the Oscillations of Insulin Secretion In Vitro and In Vivo

Diabetes (New York, N.Y.), 2002-02, Vol.51 (suppl 1), p.S144-S151

2002

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MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

The Journal of clinical investigation, 2012-10, Vol.122 (10), p.3541-3551

2012

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Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia

Diabetes (New York, N.Y.), 2002-02, Vol.51 (2), p.413-423

2002

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Glucose Acutely Reduces Cytosolic and Mitochondrial H 2 O 2 in Rat Pancreatic Beta Cells

Antioxidants & redox signaling, 2019-01, Vol.30 (3), p.297-313

2019

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Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

Aspalathin Protects Insulin‐Producing β Cells against Glucotoxicity and Oxidative Stress‐Induced Cell Death

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans

Transcriptome analysis of islets from diabetes‐resistant and diabetes‐prone obese mice reveals novel gene regulatory networks involved in beta‐cell compensation and failure

Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells

Phlda3 regulates beta cell survival during stress

Somatostatin Is Only Partly Required for the Glucagonostatic Effect of Glucose but Is Necessary for the Glucagonostatic Effect of KATP Channel Blockers

Protective antioxidant and antiapoptotic effects of ZnCl2 in rat pancreatic islets cultured in low and high glucose concentrations

Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and Above Metal Homeostasis and Antioxidant Response

Nutrient Metabolism, Subcellular Redox State, and Oxidative Stress in Pancreatic Islets and β-Cells

The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes

Proof-of-concept for 2D/CT element analysis of entire cryofrozen islets of Langerhans using a cryoloop synchrotron X-ray fluorescence setup

Glucokinase activation is beneficial or toxic to cultured rat pancreatic islets depending on the prevailing glucose concentration

The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions

Role of activating transcription factor 3 in low glucose- and thapsigargin-induced apoptosis in cultured mouse islets

NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

Signals and Pools Underlying Biphasic Insulin Secretion

The lack of functional nicotinamide nucleotide transhydrogenase only moderately contributes to the impairment of glucose tolerance and glucose-stimulated insulin secretion in C57BL/6J vs C57BL/6N mice

Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes : Many differences, few similarities

Editorial Overview: “Islet Biology in Type 2 Diabetes”

Control Mechanisms of the Oscillations of Insulin Secretion In Vitro and In Vivo

MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia

Glucose Acutely Reduces Cytosolic and Mitochondrial H 2 O 2 in Rat Pancreatic Beta Cells

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