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Positive Allosteric Modulators of Metabotropic Glutamate 1 Receptor: Characterization, Mechanism of Action, and Binding Site

Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (23), p.13402-13407

2001

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Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1666-1669

2009

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9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (20), p.4628-4631

2005

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Design, synthesis and structure–activity relationship of simple bis-amides as potent inhibitors of GlyT1

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5533-5536

2008

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Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.6960-6965

2010

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Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (18), p.5134-5139

2008

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Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors

Journal of medicinal chemistry, 2003-07, Vol.46 (15), p.3354-3370

2003

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Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4311-4315

2006

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4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4321-4325

2006

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Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4305-4310

2006

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Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlul receptor enhancers

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (6), p.1666-1669

2009

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4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum

Antimicrobial Agents and Chemotherapy, 1996-08, Vol.40 (8), p.1846-1854

1996

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A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance 1 1 Edited by T.Richmond

Journal of molecular biology, 1997-02, Vol.266 (1), p.23-30

1997

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A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance

Journal of molecular biology, 1997-02, Vol.266 (1), p.23-30

1997

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Aminothiazoles as γ-secretase modulators

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6554-6558

2011

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9 H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2 H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers

Bioorganic & medicinal chemistry letters, 2005, Vol.15 (20), p.4628-4631

2005

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The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae

Journal of molecular biology, 1999-03, Vol.287 (2), p.211-219

1999

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Aminothiazoles as [gamma]-secretase modulators

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6554-6558

2011

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Untersuchungen über aromatische Amino‐Claisen‐Umlagerungen

Helvetica chimica acta, 1977-04, Vol.60 (3), p.978-1032

1977

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P1‐246: N‐heteroaryl‐piperidinyl‐4‐amines as selective GAMMA secretase modulators for the potential treatment of Alzheimer's disease

Alzheimer's & dementia, 2012-07, Vol.8 (4S_Part_5), p.P192-P192

2012

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N-heteroaryl-piperidinyl-4-amines as selective GAMMA secretase modulators for the potential treatment of Alzheimer's disease

Alzheimer's & dementia, 2012-07, Vol.8 (4), p.P192-P192

2012

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P2‐477: Aminopyrimidines as selective γ‐secretase modulators for the potential treatment of AD

Alzheimer's & dementia, 2011-07, Vol.7 (4S_Part_13), p.S465-S465

2011

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Aminopyrimidines as selective γ-secretase modulators for the potential treatment of AD

Alzheimer's & dementia, 2011-07, Vol.7 (4), p.S465-S465

2011

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Untersuchungen über aromatische Amino-Claisen-Umlagerungen

Helvetica chimica acta, 1977-04, Vol.60 (3), p.978-1032

1977

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Positive Allosteric Modulators of Metabotropic Glutamate 1 Receptor: Characterization, Mechanism of Action, and Binding Site

Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers

9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers

Design, synthesis and structure–activity relationship of simple bis-amides as potent inhibitors of GlyT1

Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors

Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors

Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors

Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability

Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia

4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters

Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors

Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlul receptor enhancers

4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum

A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance 1 1 Edited by T.Richmond

A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance

Aminothiazoles as γ-secretase modulators

9 H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2 H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers

The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae

Aminothiazoles as [gamma]-secretase modulators

Untersuchungen über aromatische Amino‐Claisen‐Umlagerungen

P1‐246: N‐heteroaryl‐piperidinyl‐4‐amines as selective GAMMA secretase modulators for the potential treatment of Alzheimer's disease

N-heteroaryl-piperidinyl-4-amines as selective GAMMA secretase modulators for the potential treatment of Alzheimer's disease

P2‐477: Aminopyrimidines as selective γ‐secretase modulators for the potential treatment of AD

Aminopyrimidines as selective γ-secretase modulators for the potential treatment of AD

Untersuchungen über aromatische Amino-Claisen-Umlagerungen

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