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Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

Nature reviews. Drug discovery, 2014-09, Vol.13 (9), p.673-691

2014

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Targeting the epigenetic regulation of antitumour immunity

Nature reviews. Drug discovery, 2020-11, Vol.19 (11), p.776-800

2020

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New and emerging HDAC inhibitors for cancer treatment

The Journal of clinical investigation, 2014-01, Vol.124 (1), p.30-39

2014

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Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

Immunity (Cambridge, Mass.), 2012-02, Vol.36 (2), p.166-174

2012

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Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

Immunity (Cambridge, Mass.), 2012-04, Vol.36 (4), p.561-571

2012

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The TRAIL apoptotic pathway in cancer onset, progression and therapy

Nature reviews. Cancer, 2008-10, Vol.8 (10), p.782-798

2008

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Rational Combinations Using HDAC Inhibitors

Clinical cancer research, 2009-06, Vol.15 (12), p.3970-3977

2009

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Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

Cancer cell, 2012-07, Vol.22 (1), p.51-65

2012

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Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

Nature reviews. Drug discovery, 2002-04, Vol.1 (4), p.287-299

Johnstone, Ricky W

2002

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Epigenetics in cancer: Targeting chromatin modifications

Molecular cancer therapeutics, 2009-06, Vol.8 (6), p.1409-1420

2009

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How do tumor cells respond to HDAC inhibition?

The FEBS journal, 2016-11, Vol.283 (22), p.4032-4046

2016

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Anticancer activities of histone deacetylase inhibitors

Nature reviews. Drug discovery, 2006-09, Vol.5 (9), p.769-784

2006

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A chemical probe toolbox for dissecting the cancer epigenome

Nature reviews. Cancer, 2017-03, Vol.17 (3), p.160-183

2017

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Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

Cell reports (Cambridge), 2019-09, Vol.28 (11), p.2784-2794.e5

2019

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Targeting transcription cycles in cancer

Nature reviews. Cancer, 2022-01, Vol.22 (1), p.5-24

2022

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The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Science translational medicine, 2016-05, Vol.8 (339), p.339ra69

2016

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BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

Cell reports (Cambridge), 2017-02, Vol.18 (9), p.2162-2174

2017

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Enhancing the apoptotic and therapeutic effects of HDAC inhibitors

Cancer letters, 2009-08, Vol.280 (2), p.125-133

2009

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Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma

Haematologica (Roma), 2016-09, Vol.101 (9), p.e387-e390

2016

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Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies

Cancer research (Chicago, Ill.), 2012-07, Vol.72 (13), p.3163-3174

2012

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Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

The Journal of clinical investigation, 2017-03, Vol.127 (3), p.929-941

2017

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Joseph F. Sambrook (1939–2019)

Nature structural & molecular biology, 2019-10, Vol.26 (10), p.846-847

2019

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Oncogenes in cell survival and cell death

Cold Spring Harbor perspectives in biology, 2012-12, Vol.4 (12), p.a009829-a009829

2012

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Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors

Blood, 2014-02, Vol.123 (9), p.1341-1352

2014

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Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

Targeting the epigenetic regulation of antitumour immunity

New and emerging HDAC inhibitors for cancer treatment

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

The TRAIL apoptotic pathway in cancer onset, progression and therapy

Rational Combinations Using HDAC Inhibitors

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

Epigenetics in cancer: Targeting chromatin modifications

How do tumor cells respond to HDAC inhibition?

Anticancer activities of histone deacetylase inhibitors

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy

A chemical probe toolbox for dissecting the cancer epigenome

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

Targeting transcription cycles in cancer

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

Enhancing the apoptotic and therapeutic effects of HDAC inhibitors

Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma

Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Joseph F. Sambrook (1939–2019)

Oncogenes in cell survival and cell death

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors

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