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Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis

Trends in microbiology (Regular ed.), 2011-11, Vol.19 (11), p.530-539

2011

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Regulation of Rvb1/Rvb2 by a Domain within the INO80 Chromatin Remodeling Complex Implicates the Yeast Rvbs as Protein Assembly Chaperones

Cell reports (Cambridge), 2017-06, Vol.19 (10), p.2033-2044

2017

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Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

Nature (London), 2017-07, Vol.547 (7662), p.236-240

2017

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The Mycobacterium tuberculosis cytochrome P450 system

Archives of biochemistry and biophysics, 2010-01, Vol.493 (1), p.82-95

2010

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Biochemical and structural characterization of CYP124: A methyl-branched lipid ω-hydroxylase from Mycobacterium tuberculosis

Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (49), p.20687-20692

2009

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Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51

PLoS neglected tropical diseases, 2012-07, Vol.6 (7), p.e1736-e1736

2012

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A Nonazole CYP51 Inhibitor Cures Chagas’ Disease in a Mouse Model of Acute Infection

Antimicrobial Agents and Chemotherapy, 2010-06, Vol.54 (6), p.2480-2488

2010

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Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

Beilstein journal of organic chemistry, 2013-01, Vol.9 (1), p.15-25

2013

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Photosystem I from plants as a bacterial cytochrome P450 surrogate electron donor: terminal hydroxylation of branched hydrocarbon chains

Biotechnology letters, 2012-02, Vol.34 (2), p.239-245

2012

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The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction

Molecular cell, 2019-08, Vol.75 (4), p.700-710.e6

2019

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Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase

PLoS neglected tropical diseases, 2015-03, Vol.9 (3), p.e0003588

2015

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Functional Redundancy of Steroid C26-monooxygenase Activity in Mycobacterium tuberculosis Revealed by Biochemical and Genetic Analyses

The Journal of biological chemistry, 2010-11, Vol.285 (47), p.36352-36360

2010

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Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin

Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (35), p.E5108-E5116

2016

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Synthesis and interaction of terminal unsaturated chemical probes with Mycobacterium tuberculosis CYP124A1

Bioorganic & medicinal chemistry, 2021-08, Vol.44, p.116304-116304, Article 116304

2021

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4‑Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency

Journal of medicinal chemistry, 2014-08, Vol.57 (16), p.6989-7005

2014

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Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one

Molecular microbiology, 2010-08, Vol.77 (3), p.730-742

2010

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Structural control of cytochrome P450-catalyzed ω-hydroxylation

Archives of biochemistry and biophysics, 2011-03, Vol.507 (1), p.86-94

2011

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Binding Mode and Potency of N‑Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.10162-10175

2014

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Type II Isopentenyl Diphosphate Isomerase: Irreversible Inactivation by Covalent Modification of Flavin

Journal of the American Chemical Society, 2008-04, Vol.130 (14), p.4906-4913

2008

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Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans

Archives of biochemistry and biophysics, 2011-05, Vol.509 (1), p.9-15

2011

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Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1

Bioorganic & medicinal chemistry, 2012-07, Vol.20 (13), p.4064-4081

2012

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Type-2 Isopentenyl Diphosphate Isomerase. Mechanistic Studies with Cyclopropyl and Epoxy Analogues

Journal of the American Chemical Society, 2007-06, Vol.129 (25), p.7740-7741

2007

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Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase

PLoS neglected tropical diseases, 2015-03, Vol.9 (3), p.e0003588-e0003588

2015

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Liquid droplet formation by HP1 suggests a role for phase separation in heterochromatin

Nature (London), 2017-07, Vol.547 (7662), p.236

2017

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Liquid droplet formation by HP1á suggests a role for phase separation in heterochromatin

Nature (London), 2017-07, Vol.547 (7662), p.236

2017

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Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis

Regulation of Rvb1/Rvb2 by a Domain within the INO80 Chromatin Remodeling Complex Implicates the Yeast Rvbs as Protein Assembly Chaperones

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

The Mycobacterium tuberculosis cytochrome P450 system

Biochemical and structural characterization of CYP124: A methyl-branched lipid ω-hydroxylase from Mycobacterium tuberculosis

Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51

A Nonazole CYP51 Inhibitor Cures Chagas’ Disease in a Mouse Model of Acute Infection

Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

Photosystem I from plants as a bacterial cytochrome P450 surrogate electron donor: terminal hydroxylation of branched hydrocarbon chains

The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction

Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase

Functional Redundancy of Steroid C26-monooxygenase Activity in Mycobacterium tuberculosis Revealed by Biochemical and Genetic Analyses

Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin

Synthesis and interaction of terminal unsaturated chemical probes with Mycobacterium tuberculosis CYP124A1

4‑Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency

Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one

Structural control of cytochrome P450-catalyzed ω-hydroxylation

Binding Mode and Potency of N‑Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51

Type II Isopentenyl Diphosphate Isomerase: Irreversible Inactivation by Covalent Modification of Flavin

Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans

Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1

Type-2 Isopentenyl Diphosphate Isomerase. Mechanistic Studies with Cyclopropyl and Epoxy Analogues

Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase

Liquid droplet formation by HP1 suggests a role for phase separation in heterochromatin

Liquid droplet formation by HP1á suggests a role for phase separation in heterochromatin

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