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A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Nature chemical biology, 2014-09, Vol.10 (9), p.760-767

2014

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Direct control of CAR T cells through small molecule-regulated antibodies

Nature communications, 2021-01, Vol.12 (1), p.710-10, Article 710

2021

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Evaluation of a Published in Silico Model and Construction of a Novel Bayesian Model for Predicting Phospholipidosis Inducing Potential

Journal of chemical information and modeling, 2007-05, Vol.47 (3), p.1196-1205

2007

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A Strategy for Risk Management of Drug-Induced Phospholipidosis

Toxicologic pathology, 2009-12, Vol.37 (7), p.997-1005

2009

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Protein tyrosine phosphatase 1B inhibitors for diabetes

Nature reviews. Drug discovery, 2002-09, Vol.1 (9), p.696-709

2002

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Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3002-3019

2017

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Pyrimidone-based series of glucokinase activators with alternative donor–acceptor motif

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4571-4578

2013

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N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275

Bioorganic & medicinal chemistry letters, 2009-07, Vol.19 (13), p.3493-3497

2009

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First total synthesis of Lycopodium alkaloids of the magellanane group. Enantioselective total syntheses of (-)-magellanine and (+)-magellaninone

Journal of the American Chemical Society, 1993-04, Vol.115 (7), p.2992-2993

1993

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N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Strategies to eliminate reactive metabolites

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (8), p.2344-2348

2013

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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. Part 7: Structure–Activity Studies of Bicyclic 2-Pyridone-Containing Peptidomimetics

Bioorganic & medicinal chemistry letters, 2002-03, Vol.12 (5), p.733-738

2002

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Structure-Based Design of a Parallel Synthetic Array Directed Toward the Discovery of Irreversible Inhibitors of Human Rhinovirus 3C Protease

Journal of medicinal chemistry, 2002-05, Vol.45 (10), p.2016-2023

2002

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Discovery of N -((3 R ,4 R )-4-Fluoro-1-(6-((3-methoxy-1-methyl-1 H -pyrazol-4-yl)amino)-9-methyl-9 H -purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3002-3019

2017

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N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11[beta]-hydroxysteroid dehydrogenase type 1: Strategies to eliminate reactive metabolites

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (8), p.2344-2348

2013

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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 8. Pharmacological Optimization of Orally Bioavailable 2-Pyridone-Containing Peptidomimetics

Journal of medicinal chemistry, 2003-10, Vol.46 (21), p.4572-4585

2003

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Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library

Bioorganic & medicinal chemistry letters, 1998-09, Vol.8 (17), p.2315-2320

1998

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Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D

Bioorganic & medicinal chemistry letters, 1998-11, Vol.8 (22), p.3203-3206

1998

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Glucokinase Activators for the Treatment of Type 2 Diabetes

Annual Reports in Medicinal Chemistry, 2006, Vol.41, p.141-154

2006

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N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275

Bioorganic & medicinal chemistry letters, 2009-07, Vol.19 (13), p.3493-3497

2009

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Ring-enlarging cyclopentene annulations

Tetrahedron letters, 1991-12, Vol.32 (50), p.7361-7364

1991

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Evaluation of a Published in silico Model and Construction of a Novel Bayesian Model for Predicting Phospholipidosis Inducing Potential

ChemInform, 2007-08, Vol.38 (34), p.no-no

2007

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Credit Terms

Business credit, 1984-01, Vol.86 (1), p.23

Johnson, Theodore O

1984

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TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle

Nature (London), 2018-11, Vol.563 (7732), p.508-513

2018

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Nocturia Frequency, Bother, and Quality of Life: How Often Is Too Often? A Population-Based Study in Finland

European urology, 2010-03, Vol.57 (3), p.488-498

2010

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The Impact of Nocturia on Falls and Fractures: A Systematic Review and Meta-Analysis

The Journal of urology, 2020-04, Vol.203 (4), p.674-683

2020

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A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Direct control of CAR T cells through small molecule-regulated antibodies

Evaluation of a Published in Silico Model and Construction of a Novel Bayesian Model for Predicting Phospholipidosis Inducing Potential

A Strategy for Risk Management of Drug-Induced Phospholipidosis

Protein tyrosine phosphatase 1B inhibitors for diabetes

Pyrimidone-based series of glucokinase activators with alternative donor–acceptor motif

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275

First total synthesis of Lycopodium alkaloids of the magellanane group. Enantioselective total syntheses of (-)-magellanine and (+)-magellaninone

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Strategies to eliminate reactive metabolites

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. Part 7: Structure–Activity Studies of Bicyclic 2-Pyridone-Containing Peptidomimetics

Structure-Based Design of a Parallel Synthetic Array Directed Toward the Discovery of Irreversible Inhibitors of Human Rhinovirus 3C Protease

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11[beta]-hydroxysteroid dehydrogenase type 1: Strategies to eliminate reactive metabolites

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 8. Pharmacological Optimization of Orally Bioavailable 2-Pyridone-Containing Peptidomimetics

Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library

Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D

Glucokinase Activators for the Treatment of Type 2 Diabetes

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275

Ring-enlarging cyclopentene annulations

Evaluation of a Published in silico Model and Construction of a Novel Bayesian Model for Predicting Phospholipidosis Inducing Potential

Credit Terms

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle

Nocturia Frequency, Bother, and Quality of Life: How Often Is Too Often? A Population-Based Study in Finland

The Impact of Nocturia on Falls and Fractures: A Systematic Review and Meta-Analysis

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