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TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets

PloS one, 2017-10, Vol.12 (10), p.e0187262-e0187262

2017

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The pivotal role of cytotoxic NK cells in mediating the therapeutic effect of anti-CD47 therapy in mycosis fungoides

Cancer Immunology, Immunotherapy, 2022-04, Vol.71 (4), p.919-932

2022

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Transfusion management in the era of magrolimab (Hu5F9‐G4), an anti‐CD47 monoclonal antibody therapy

Transfusion (Philadelphia, Pa.), 2023-12, Vol.63 (12), p.2377-2383

2023

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Quantification of a proteotypic peptide from protein C inhibitor by liquid chromatography-free SISCAPA-MALDI mass spectrometry: application to identification of recurrence of prostate cancer

Clinical chemistry (Baltimore, Md.), 2013-10, Vol.59 (10), p.1514-1522

2013

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Targeting CD47-SIRPa axis shows potent preclinical anti-tumor activity as monotherapy and synergizes with PARP inhibition

NPJ precision oncology, 2023-07, Vol.7 (1), p.69-69, Article 69

2023

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TGF-β sensitivity restrains CD8+ T cell homeostatic proliferation by enforcing sensitivity to IL-7 and IL-15

PloS one, 2012-08, Vol.7 (8), p.e42268-e42268

2012

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Phase I Study of the CD47 Blocker TTI-621 in Patients with Relapsed or Refractory Hematologic Malignancies

Clinical cancer research, 2021-04, Vol.27 (8), p.2190-2199

2021

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Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines

PloS one, 2010-12, Vol.5 (12), p.e15625-e15625

2010

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A Chronic Need for IL-21

Science (American Association for the Advancement of Science), 2009-06, Vol.324 (5934), p.1525-1526

2009

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The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion

The Journal of experimental medicine, 2009-02, Vol.206 (2), p.435-448

2009

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TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding

Clinical cancer research, 2017-02, Vol.23 (4), p.1068-1079

2017

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Negative regulators in homeostasis of naïve peripheral T cells

Immunologic research, 2008-06, Vol.41 (2), p.137-153

2008

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Targeting CD47 in Sézary syndrome with SIRPαFc

Blood advances, 2019-04, Vol.3 (7), p.1145-1153

2019

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Histidine rich glycoprotein and cancer: a multi-faceted relationship

Anticancer research, 2014-02, Vol.34 (2), p.593-603

2014

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Self-specific CD8+ T cells maintain a semi-naive state following lymphopenia-induced proliferation

The Journal of immunology (1950), 2010-05, Vol.184 (10), p.5604-5611

2010

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Children's Mental Health in Child Welfare: A Child-Focused Curriculum for Child Welfare Workers and Social Work Students

Journal of teaching in social work, 2006-01, Vol.26 (3-4), p.19-40

2006

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TGF-[beta] Sensitivity Restrains CD8+ T Cell Homeostatic Proliferation by Enforcing Sensitivity to IL-7 and IL-15.(Research Article)

PloS one, 2012-08, Vol.7 (8), p.e42268

2012

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TTI-621

PloS one, 2017-10, Vol.12 (10), p.e0187262

2017

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Abstract 2653: The anti-myeloma activity of TTI-621 (SIRPαFc), a CD47-blocking immunotherapeutic, is enhanced when combined with a proteasome inhibitor

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.2653-2653

2017

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Abstract 2646: Intratumoral delivery of TTI-621 (SIRPαFc), a CD47-blocking immunotherapeutic, inhibits tumor growth and prolongs animal survival in a subcutaneous B cell lymphoma model

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.2646-2646

2017

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Abstract 2709: TTI-622 (SIRPα-IgG4 Fc), a CD47-blocking innate immune checkpoint inhibitor, suppresses tumor growth and demonstrates enhanced efficacy in combination with antitumor antibodies in both hematologic and solid tumor models

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2709-2709

2018

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Abstract 2345: SIRPαFc, a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by both classically (M1) and alternatively (M2) activated macrophages

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2345-2345

2016

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Abstract B028: Blockade of the CD47 “Do not eat” signal by TTI-621 (SIRPαFc) leads to enhanced antitumor CD8+ T cell responses in vitro

Cancer immunology research, 2016-11, Vol.4 (11_Supplement), p.B028-B028

2016

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Intralesional Administration of the CD47 Antagonist TTI-621 (SIRPαFc) Induces Responses in Both Injected and Non-Injected Lesions in Patients with Relapsed/Refractory Mycosis Fungoides and Sézary Syndrome: Interim Results of a Multicenter Phase I Trial

Blood, 2018-11, Vol.132 (Supplement 1), p.1653-1653

2018

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Intralesional Injection of the CD47-blocking immune checkpoint inhibitor TTI-621 (SIRPaFc) induces antitumor activity in patients with relapsed/refractory mycosis fungoides and Sézary syndrome: Interim results of a multicenter Phase 1 trial

European journal of cancer (1990), 2018-09, Vol.101, p.S34-S34

2018

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