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TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death in Arabidopsis

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (10), p.E2053-E2062

2017

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Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

eLife, 2019-12, Vol.8 (2019)

2019

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Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways

The Journal of cell biology, 2019-09, Vol.218 (9), p.3077-3097

2019

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Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction

Blood, 2016-09, Vol.128 (9), p.1282-1289

2016

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Regulation of phospholipase C isozymes by ras superfamily GTPases

Annual review of pharmacology and toxicology, 2006-01, Vol.46 (1), p.355-379

2006

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Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation

Proceedings of the National Academy of Sciences - PNAS, 2005-05, Vol.102 (18), p.6496-6501

2005

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Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

eLife, 2022-06, Vol.11

2022

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Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

Oncogene, 2004-12, Vol.23 (58), p.9369-9380

2004

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Small Molecule Inhibitors of Phospholipase C from a Novel High-throughput Screen

The Journal of biological chemistry, 2013-02, Vol.288 (8), p.5840-5848

2013

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Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

Nature cell biology, 2002-08, Vol.4 (8), p.621-625

2002

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Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

Nature structural & molecular biology, 2007-09, Vol.14 (9), p.814-823

2007

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A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation

Biochemical and biophysical research communications, 2016-05, Vol.474 (1), p.193-198

2016

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Direct Activation of Human Phospholipase C by Its Well Known Inhibitor U73122

The Journal of biological chemistry, 2011-04, Vol.286 (14), p.12407-12416

2011

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Crystal structure of Rac1 bound to its effector phospholipase C-β2

Nature structural & molecular biology, 2006-12, Vol.13 (12), p.1135-1140

2006

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Activation of Human Phospholipase C-η2 by Gβγ

Biochemistry (Easton), 2008-04, Vol.47 (15), p.4410-4417

2008

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Phagocytosis of Apoptotic Cells Is Regulated by a UNC-73/TRIO-MIG-2/RhoG Signaling Module and Armadillo Repeats of CED-12/ELMO

Current biology, 2004-12, Vol.14 (24), p.2208-2216

2004

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Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

Nature structural & molecular biology, 2002-06, Vol.9 (6), p.468-475

2002

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Phospholipase C isozymes as effectors of Ras superfamily GTPases

Journal of lipid research, 2009-04, Vol.50 (Suppl), p.S243-S248

2009

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Role of the C-Terminal SH3 Domain and N-Terminal Tyrosine Phosphorylation in Regulation of Tim and Related Dbl-Family Proteins

Biochemistry (Easton), 2008-07, Vol.47 (26), p.6827-6839

2008

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A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

The EMBO journal, 2002-03, Vol.21 (6), p.1315-1326

2002

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Structure and Function of Vps15 in the Endosomal G Protein Signaling Pathway

Biochemistry (Easton), 2009-07, Vol.48 (27), p.6390-6401

2009

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AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana

PloS one, 2012-08, Vol.7 (8), p.e42633

2012

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Type III effector activation via nucleotide binding, phosphorylation, and host target interaction

PLoS pathogens, 2007-03, Vol.3 (3), p.e48-e48

2007

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A Steric-Inhibition Model for Regulation of Nucleotide Exchange via the Dock180 Family of GEFs

Current biology, 2005-02, Vol.15 (4), p.371-377

2005

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Structural and Biochemical Characterization of CIB1 Delineates a New Family of EF-hand-containing Proteins

The Journal of biological chemistry, 2005-03, Vol.280 (9), p.8407-8415

2005

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TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death in Arabidopsis

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction

Regulation of phospholipase C isozymes by ras superfamily GTPases

Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

Small Molecule Inhibitors of Phospholipase C from a Novel High-throughput Screen

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation

Direct Activation of Human Phospholipase C by Its Well Known Inhibitor U73122

Crystal structure of Rac1 bound to its effector phospholipase C-β2

Activation of Human Phospholipase C-η2 by Gβγ

Phagocytosis of Apoptotic Cells Is Regulated by a UNC-73/TRIO-MIG-2/RhoG Signaling Module and Armadillo Repeats of CED-12/ELMO

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

Phospholipase C isozymes as effectors of Ras superfamily GTPases

Role of the C-Terminal SH3 Domain and N-Terminal Tyrosine Phosphorylation in Regulation of Tim and Related Dbl-Family Proteins

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

Structure and Function of Vps15 in the Endosomal G Protein Signaling Pathway

AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana

Type III effector activation via nucleotide binding, phosphorylation, and host target interaction

A Steric-Inhibition Model for Regulation of Nucleotide Exchange via the Dock180 Family of GEFs

Structural and Biochemical Characterization of CIB1 Delineates a New Family of EF-hand-containing Proteins

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