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GABAA Receptor Subtype-Selective Modulators. I. α2/α3-Selective Agonists as Non-Sedating Anxiolytics

Current topics in medicinal chemistry, 2011-05, Vol.11 (9), p.1176-1202

R. Atack, John

2011

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GABAA Receptor Subtype-Selective Modulators. II. α5-Selective Inverse Agonists for Cognition Enhancement

Current topics in medicinal chemistry, 2011-05, Vol.11 (9), p.1203-1214

R. Atack, John

2011

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The complexity of the GABAA receptor shapes unique pharmacological profiles

Drug discovery today, 2009-09, Vol.14 (17-18), p.866-875

2009

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Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2

Biochemical journal, 2016-07, Vol.473 (13), p.1869-1879

2016

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Exploring Calbindin-IMPase fusion proteins structure and activity

Biochemistry and biophysics reports, 2022-07, Vol.30, p.101266-101266, Article 101266

2022

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Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates

Proceedings of the National Academy of Sciences - PNAS, 2005-01, Vol.102 (3), p.915-920

2005

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Subtype Selective γ‑Aminobutyric Acid Type A Receptor (GABAAR) Modulators Acting at the Benzodiazepine Binding Site: An Update

Journal of medicinal chemistry, 2020-04, Vol.63 (7), p.3425-3446

2020

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Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782

The Journal of pharmacology and experimental therapeutics, 2013-09, Vol.346 (3), p.514-527

2013

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Neurosteroid Modulation of Synaptic and Extrasynaptic GABAA Receptors of the Mouse Nucleus Accumbens

Biomolecules (Basel, Switzerland), 2024-04, Vol.14 (4), p.460

2024

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A Biophysical Approach to the Identification of Novel ApoE Chemical Probes

Biomolecules (Basel, Switzerland), 2019-01, Vol.9 (2), p.48

2019

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Preclinical and clinical pharmacology of the GABAA receptor α5 subtype-selective inverse agonist α5IA

Pharmacology & therapeutics (Oxford), 2010-01, Vol.125 (1), p.11-26

Atack, John R.

2010

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Cocaine effects on mouse incentive-learning and human addiction are linked to α2 subunit-containing GABAA receptors

Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (5), p.2289-2294

2010

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Relating neurosteroid modulation of inhibitory neurotransmission to behaviour

Journal of neuroendocrinology, 2022-02, Vol.34 (2), p.e13045-n/a

2022

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Imidazo[1,2-a]pyrimidines as Functionally Selective and Orally Bioavailable GABAAα2/α3 Binding Site Agonists for the Treatment of Anxiety Disorders

Journal of medicinal chemistry, 2006-01, Vol.49 (1), p.35-38

2006

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Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

Communications biology, 2022-04, Vol.5 (1), p.346-346, Article 346

2022

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The benzodiazepine binding site of GABAA receptors as a target for the development of novel anxiolytics

Expert opinion on investigational drugs, 2005-05, Vol.14 (5), p.601-618

Atack, John R

2005

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Multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated 18F-fluorination

EJNMMI radiopharmacy and chemistry, 2022-03, Vol.7 (1), p.5-5, Article 5

2022

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A toolkit for the identification of NEAT1_2/paraspeckle modulators

Nucleic acids research, 2022-11, Vol.50 (20), p.e119-e119

2022

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Basmisanil, an α5-GABAAR negative allosteric modulator, produces rapid and sustained antidepressant-like responses in male mice

Neuroscience letters, 2024-06, Vol.833, p.137828, Article 137828

2024

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The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease

Journal of molecular biology, 2019-05, Vol.431 (12), p.2248-2265

2019

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Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity

Behavioural pharmacology, 2008-03, Vol.19 (2), p.153-159

2008

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Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity

Journal of medicinal chemistry, 2022-10, Vol.65 (20), p.13705-13713

2022

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Co‐crystallization of human inositol monophosphatase with the lithium mimetic L‐690,330

Acta crystallographica. Section D, Biological crystallography., 2018-10, Vol.74 (10), p.973-978

2018

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The X‐ray structure of human calbindin‐D28K: an improved model

Acta crystallographica. Section D, Biological crystallography., 2018-10, Vol.74 (10), p.1008-1014

2018

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Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans

The Journal of pharmacology and experimental therapeutics, 2010-01, Vol.332 (1), p.17

2010

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GABAA Receptor Subtype-Selective Modulators. I. α2/α3-Selective Agonists as Non-Sedating Anxiolytics

GABAA Receptor Subtype-Selective Modulators. II. α5-Selective Inverse Agonists for Cognition Enhancement

The complexity of the GABAA receptor shapes unique pharmacological profiles

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2

Exploring Calbindin-IMPase fusion proteins structure and activity

Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates

Subtype Selective γ‑Aminobutyric Acid Type A Receptor (GABAAR) Modulators Acting at the Benzodiazepine Binding Site: An Update

Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782

Neurosteroid Modulation of Synaptic and Extrasynaptic GABAA Receptors of the Mouse Nucleus Accumbens

A Biophysical Approach to the Identification of Novel ApoE Chemical Probes

Preclinical and clinical pharmacology of the GABAA receptor α5 subtype-selective inverse agonist α5IA

Cocaine effects on mouse incentive-learning and human addiction are linked to α2 subunit-containing GABAA receptors

Relating neurosteroid modulation of inhibitory neurotransmission to behaviour

Imidazo[1,2-a]pyrimidines as Functionally Selective and Orally Bioavailable GABAAα2/α3 Binding Site Agonists for the Treatment of Anxiety Disorders

Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

The benzodiazepine binding site of GABAA receptors as a target for the development of novel anxiolytics

Multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated 18F-fluorination

A toolkit for the identification of NEAT1_2/paraspeckle modulators

Basmisanil, an α5-GABAAR negative allosteric modulator, produces rapid and sustained antidepressant-like responses in male mice

The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease

Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity

Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity

Co‐crystallization of human inositol monophosphatase with the lithium mimetic L‐690,330

The X‐ray structure of human calbindin‐D28K: an improved model

Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans

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