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Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors

Journal of clinical oncology, 2012-07, Vol.30 (19), p.2348-2353

2012

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BRAFV600E negatively regulates the AKT pathway in melanoma cell lines

PloS one, 2012-08, Vol.7 (8), p.e42598

2012

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The Systemic Inflammatory Response to Cardiac Surgery

Anesthesiology (Philadelphia), 2002-07, Vol.97 (1), p.215-252

2002

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The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma

PloS one, 2011-09, Vol.6 (9), p.e25264-e25264

2011

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Discovery of siRNA Lipid Nanoparticles to Transfect Suspension Leukemia Cells and Provide In Vivo Delivery Capability

Molecular therapy, 2014-02, Vol.22 (2), p.359-370

2014

Volltextzugriff (PDF)

Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells

Molecular cancer therapeutics, 2011-11, Vol.10 (11), p.2104-2114

2011

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SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia

Oncogene, 2003-05, Vol.22 (18), p.2823-2835

2003

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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.8989-9002

2017

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Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties

Cancer research (Chicago, Ill.), 2009-10, Vol.69 (19), p.7672-7680

2009

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Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1–S Checkpoint

Molecular cancer therapeutics, 2018-08, Vol.17 (8), p.1727-1738

2018

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Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity

Journal of medicinal chemistry, 2021-09, Vol.64 (17), p.12670-12679

2021

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Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G 1 -S Checkpoint

Molecular cancer therapeutics, 2018-08, Vol.17 (8), p.1727

2018

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Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4401-4410

2019

Volltextzugriff (PDF)

Identification of the MEK1(F129L) Activating Mutation as a Potential Mechanism of Acquired Resistance to MEK Inhibition in Human Cancers Carrying the B-Raf V600E Mutation

Cancer research (Chicago, Ill.), 2011-08, Vol.71 (16), p.5535-5545

2011

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What do we treat when we treat ARDS?

Intensive care medicine, 2016-02, Vol.42 (2), p.284-286

2016

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The name of the game: no transfusion (or nontransfusion) by cookbook

Anesthesiology (Philadelphia), 2008-10, Vol.109 (4), p.745-746

2008

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Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors

Anti-cancer drugs, 2015-03, Vol.26 (3), p.272-283

2015

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Hypercapnic Acidosis Attenuates Endotoxin-induced Acute Lung Injury

American journal of respiratory and critical care medicine, 2004-01, Vol.169 (1), p.46-56

2004

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Erector Spinae Plane Blocks in Major Hepatopancreaticobiliary Surgery: A Case Series

A&A practice, 2019-11, Vol.13 (9), p.332

2019

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Fatal Fibrinolysis During Orthotopic Liver Transplantation in Patients Receiving Solvent/Detergent-Treated Plasma (Octaplas)

Journal of cardiothoracic and vascular anesthesia, 2007-06, Vol.21 (3), p.410-413

2007

Volltextzugriff (PDF)

Cyclin-Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation

Journal of medicinal chemistry, 2000-01, Vol.43 (1), p.1-18

2000

Volltextzugriff (PDF)

Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3

Journal of medicinal chemistry, 2002-11, Vol.45 (24), p.5233-5248

2002

Volltextzugriff (PDF)

Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors

Gene, 2004-03, Vol.328, p.135-142

2004

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Emergency airway management: competence versus expertise?

Anesthesiology (Philadelphia), 2008-12, Vol.109 (6), p.945-947

2008

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Identification of novel, potent and selective inhibitors of Polo-like kinase 1

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1247-1250

2012

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Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors

BRAFV600E negatively regulates the AKT pathway in melanoma cell lines

The Systemic Inflammatory Response to Cardiac Surgery

The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma

Discovery of siRNA Lipid Nanoparticles to Transfect Suspension Leukemia Cells and Provide In Vivo Delivery Capability

Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells

SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen

Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties

Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1–S Checkpoint

Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity

Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G 1 -S Checkpoint

Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy

Identification of the MEK1(F129L) Activating Mutation as a Potential Mechanism of Acquired Resistance to MEK Inhibition in Human Cancers Carrying the B-Raf V600E Mutation

What do we treat when we treat ARDS?

The name of the game: no transfusion (or nontransfusion) by cookbook

Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors

Hypercapnic Acidosis Attenuates Endotoxin-induced Acute Lung Injury

Erector Spinae Plane Blocks in Major Hepatopancreaticobiliary Surgery: A Case Series

Fatal Fibrinolysis During Orthotopic Liver Transplantation in Patients Receiving Solvent/Detergent-Treated Plasma (Octaplas)

Cyclin-Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation

Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3

Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors

Emergency airway management: competence versus expertise?

Identification of novel, potent and selective inhibitors of Polo-like kinase 1

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