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A novel method for determination of drug distribution in rat brain tissue sections by LC/MS/MS: functional tissue microanalysis

Current topics in medicinal chemistry, 2012-06, Vol.12 (11), p.1243

2012

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Dihydroquinone Ansamycins: Toward Resolving the Conflict between Low in Vitro Affinity and High Cellular Potency of Geldanamycin Derivatives

Biochemistry (Easton), 2006-05, Vol.45 (17), p.5678-5685

2006

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Investigation of vesicle electrokinetic chromatography as an in vitro assay for the estimation of intestinal permeability of pharmaceutical drug candidates

Electrophoresis, 2006-02, Vol.27 (4), p.793-804

2006

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Biotransformation of geldanamycin and 17-allylamino-17-demethoxygeldanamycin by human liver microsomes: reductive versus oxidative metabolism and implications

Drug metabolism and disposition, 2007-01, Vol.35 (1), p.21

2007

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Liquid chromatographic and tandem mass spectrometric assay for evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors: application of biomarkers in drug discovery

Analytical biochemistry, 2004-10, Vol.333 (1), p.79-87

2004

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Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?

European journal of drug metabolism and pharmacokinetics, 2004-04, Vol.29 (2), p.133-143

2004

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Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site

ACS medicinal chemistry letters, 2011-07, Vol.2 (7), p.538-543

2011

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Cone voltage induced in-source dissociation of glucuronides in electrospray and implications in biological analyses

Rapid communications in mass spectrometry, 2003-01, Vol.17 (13), p.1433-1442

2003

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Structural Basis for Elastolytic Substrate Specificity in Rodent α-Chymases

The Journal of biological chemistry, 2008-01, Vol.283 (1), p.427-436

2008

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Novel LC/MS/MS and High-Throughput Mass Spectrometric Assays for Monoacylglycerol Acyltransferase Inhibitors

SLAS discovery, 2017-04, Vol.22 (4), p.433-439

2017

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The use of the suicide CYP450 inhibitor ABT for distinguishing absorption and metabolism processes in in-vivo pharmacokinetic screens

European journal of drug metabolism and pharmacokinetics, 2005-01, Vol.30 (1-2), p.75-83

2005

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Synthesis and Biological Evaluation of Novel Pyridazinone-Based α4 Integrin Receptor Antagonists

Journal of medicinal chemistry, 2006-06, Vol.49 (11), p.3402-3411

2006

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Evaluation of the immobilized artificial membrane phosphatidylcholine: Drug discovery column for high-performance liquid chromatographic screening of drug–membrane interactions

Journal of Chromatography A, 1998-03, Vol.800 (2), p.161-169

1998

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Evaluation of the effect of oxygen exposure on human liver microsomal metabolism of mitomycin C in the presence of glutathione using liquid chromatography-quadrupole time of flight mass spectrometry

Analytical biochemistry, 2005-08, Vol.343 (2), p.268-276

2005

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Correction to Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site

ACS medicinal chemistry letters, 2012-03, Vol.3 (3), p.263-263

2012

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Comparison of the retention behavior of β-blockers using immobilized artificial membrane chromatography and lysophospholipid micellar electrokinetic chromatography

Journal of Chromatography A, 1998-06, Vol.810 (1), p.95-103

1998

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Distribution and metabolism of the antipsychotic agent mazapertine succinate in rats

Journal of pharmaceutical and biomedical analysis, 2006-05, Vol.41 (2), p.500-509

2006

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The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery

Current topics in medicinal chemistry, 2001-11, Vol.1 (5), p.353

2001

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Investigation of vesicle electrokinetic chromatography as anin vitro assay for the estimation of intestinal permeability of pharmaceutical drug candidates

Electrophoresis, 2006-04, Vol.27 (7), p.1433-1433

2006

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Evaluation of the effect of oxygen exposure on human liver microsomal metabolism of mitomycin C in the presence of glutathioneusing liquid chromatography–quadrupole time of flight mass spectrometry

Analytical biochemistry, 2005-08, Vol.343 (2), p.268-276

2005

Volltextzugriff (PDF)

Investigation of vesicle electrokinetic chromatography as an in vitro assay for the estimation of intestinal permeability of pharmaceutical drug candidates

Electrophoresis, 2006-04, Vol.27 (7), p.1433-1433

2006

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Structural Basis for Elastolytic Substrate Specificity in Rodent Î±-Chymases

The Journal of biological chemistry, 2008-01, Vol.283 (1), p.427

2008

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In vitro permeability of eight β-blockers through Caco-2 monolayers utilizing liquid chromatography/electrospray ionization mass spectrometry

Journal of mass spectrometry., 1998-07, Vol.33 (7), p.607-614

1998

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Using capillary electrophoresis/frontal analysis to screen drugs interacting with human serum proteins

Electrophoresis, 1998-03, Vol.19 (3), p.448-454

1998

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In vivo microdialysis and liquid chromatography/thermospray mass spectrometry of the novel anticonvulsant 2,3:4,5-bis-o-(1-methylethylidene)-β-D-fructopyranose sulfamate (topiramate) in rat brain fluid

Journal of mass spectrometry., 1998-01, Vol.33 (1), p.85-88

1998

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A novel method for determination of drug distribution in rat brain tissue sections by LC/MS/MS: functional tissue microanalysis

Dihydroquinone Ansamycins: Toward Resolving the Conflict between Low in Vitro Affinity and High Cellular Potency of Geldanamycin Derivatives

Investigation of vesicle electrokinetic chromatography as an in vitro assay for the estimation of intestinal permeability of pharmaceutical drug candidates

Biotransformation of geldanamycin and 17-allylamino-17-demethoxygeldanamycin by human liver microsomes: reductive versus oxidative metabolism and implications

Liquid chromatographic and tandem mass spectrometric assay for evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors: application of biomarkers in drug discovery

Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?

Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site

Cone voltage induced in-source dissociation of glucuronides in electrospray and implications in biological analyses

Structural Basis for Elastolytic Substrate Specificity in Rodent α-Chymases

Novel LC/MS/MS and High-Throughput Mass Spectrometric Assays for Monoacylglycerol Acyltransferase Inhibitors

The use of the suicide CYP450 inhibitor ABT for distinguishing absorption and metabolism processes in in-vivo pharmacokinetic screens

Synthesis and Biological Evaluation of Novel Pyridazinone-Based α4 Integrin Receptor Antagonists

Evaluation of the immobilized artificial membrane phosphatidylcholine: Drug discovery column for high-performance liquid chromatographic screening of drug–membrane interactions

Evaluation of the effect of oxygen exposure on human liver microsomal metabolism of mitomycin C in the presence of glutathione using liquid chromatography-quadrupole time of flight mass spectrometry

Correction to Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site

Comparison of the retention behavior of β-blockers using immobilized artificial membrane chromatography and lysophospholipid micellar electrokinetic chromatography

Distribution and metabolism of the antipsychotic agent mazapertine succinate in rats

The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery

Investigation of vesicle electrokinetic chromatography as anin vitro assay for the estimation of intestinal permeability of pharmaceutical drug candidates

Evaluation of the effect of oxygen exposure on human liver microsomal metabolism of mitomycin C in the presence of glutathioneusing liquid chromatography–quadrupole time of flight mass spectrometry

Investigation of vesicle electrokinetic chromatography as an in vitro assay for the estimation of intestinal permeability of pharmaceutical drug candidates

Structural Basis for Elastolytic Substrate Specificity in Rodent Î±-Chymases

In vitro permeability of eight β-blockers through Caco-2 monolayers utilizing liquid chromatography/electrospray ionization mass spectrometry

Using capillary electrophoresis/frontal analysis to screen drugs interacting with human serum proteins

In vivo microdialysis and liquid chromatography/thermospray mass spectrometry of the novel anticonvulsant 2,3:4,5-bis-o-(1-methylethylidene)-β-D-fructopyranose sulfamate (topiramate) in rat brain fluid

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