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Immunological aspects of intestinal mucus and mucins

Nature reviews. Immunology, 2016-10, Vol.16 (10), p.639

2016

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Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by in vivo labeling of mucin glycoproteins

PloS one, 2012-07, Vol.7 (7), p.e41009

2012

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Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model

PloS one, 2010-08, Vol.5 (8), p.e12238

2010

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A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

Science (American Association for the Advancement of Science), 2016-06, Vol.352 (6293), p.1535-1542

2016

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Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (15), p.5645-5650

2012

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two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (Supplement 1), p.4659-4665

2011

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Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture

PloS one, 2014-01, Vol.9 (1), p.e85254

2014

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inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (39), p.15064-15069

2008

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Composition and functional role of the mucus layers in the intestine

Cellular and molecular life sciences : CMLS, 2011-11, Vol.68 (22), p.3635-3641

2011

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The composition of the gut microbiota shapes the colon mucus barrier

EMBO reports, 2015-02, Vol.16 (2), p.164-177

2015

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The role of goblet cells and mucus in intestinal homeostasis

Nature reviews. Gastroenterology & hepatology, 2022-12, Vol.19 (12), p.785

2022

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The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins

Nature communications, 2023-04, Vol.14 (1), p.1969-1969, Article 1969

2023

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Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis

PloS one, 2014-06, Vol.9 (6), p.e100217-e100217

2014

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Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (48), p.13833-13838

2016

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The gastrointestinal mucus system in health and disease

Nature reviews. Gastroenterology & hepatology, 2013-06, Vol.10 (6), p.352

2013

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An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

Science (American Association for the Advancement of Science), 2021-04, Vol.372 (6539)

2021

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Potential roles of gut microbiome and metabolites in modulating ALS in mice

Nature (London), 2019-08, Vol.572 (7770), p.474

2019

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Increased Understanding of the Biochemistry and Biosynthesis of MUC2 and Other Gel-Forming Mucins Through the Recombinant Expression of Their Protein Domains

Molecular biotechnology, 2013-06, Vol.54 (2), p.250-256

2013

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Helicobacter pylori Infection Impairs the Mucin Production Rate and Turnover in the Murine Gastric Mucosa

Infection and Immunity, 2013-03, Vol.81 (3), p.829-837

2013

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Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches

American journal of physiology: Gastrointestinal and liver physiology, 2013-09, Vol.305 (5), p.G341-G347

2013

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Study of mucin turnover in the small intestine by in vivo labeling

Scientific reports, 2018-04, Vol.8 (1), p.5760-11, Article 5760

2018

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The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

Immunological reviews, 2014-07, Vol.260 (1), p.8-20

2014

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The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice

PloS one, 2015-07, Vol.10 (7), p.e0131991

2015

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Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer

Nature communications, 2022-01, Vol.13 (1), p.45-45, Article 45

2022

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Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

The Journal of experimental medicine, 2012-07, Vol.209 (7), p.1263-1272

2012

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Immunological aspects of intestinal mucus and mucins

Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by in vivo labeling of mucin glycoproteins

Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture

inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Composition and functional role of the mucus layers in the intestine

The composition of the gut microbiota shapes the colon mucus barrier

The role of goblet cells and mucus in intestinal homeostasis

The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins

Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis

Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16

The gastrointestinal mucus system in health and disease

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

Potential roles of gut microbiome and metabolites in modulating ALS in mice

Increased Understanding of the Biochemistry and Biosynthesis of MUC2 and Other Gel-Forming Mucins Through the Recombinant Expression of Their Protein Domains

Helicobacter pylori Infection Impairs the Mucin Production Rate and Turnover in the Murine Gastric Mucosa

Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches

Study of mucin turnover in the small intestine by in vivo labeling

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice

Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

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