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Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen

The Journal of biological chemistry, 2010-11, Vol.285 (45), p.34950-34959

2010

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Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase

Nucleic acids research, 2023-05, Vol.51 (8), p.3754

2023

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Computational redesign of a fluorogen activating protein with Rosetta

PLoS computational biology, 2021-11, Vol.17 (11), p.e1009555-e1009555

2021

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Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

Nucleic acids research, 2018-09, Vol.46 (16), p.8090

2018

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Synthesis and Structure–Activity Relationships of 5,6,7-Substituted Pyrazolopyrimidines: Discovery of a Novel TSPO PET Ligand for Cancer Imaging

Journal of medicinal chemistry, 2013-04, Vol.56 (8), p.3429-3433

2013

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Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR

Molecular cell, 2003-04, Vol.11 (4), p.1093-1100

2003

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Evaluation of TSPO PET Ligands [18F]VUIIS1009A and [18F]VUIIS1009B: Tracers for Cancer Imaging

Molecular imaging and biology, 2017-08, Vol.19 (4), p.578-588

2017

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Cryo‐neutron crystallographic data collection and preliminary refinement of left‐handed Z‐DNA d(CGCGCG)

Acta crystallographica. Section F, Structural biology communications, 2018-10, Vol.74 (10), p.603-609

2018

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Methylation of Histone H3 by Coactivator-Associated Arginine Methyltransferase 1

Biochemistry (Easton), 2001-05, Vol.40 (19), p.5747-5756

2001

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Structure and Function of YghU, a Nu-Class Glutathione Transferase Related to YfcG from Escherichia coli

Biochemistry (Easton), 2011-02, Vol.50 (7), p.1274-1281

2011

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Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers

Organic letters, 2023-02, Vol.25 (6), p.901-906

2023

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Phosphorus SAD Phasing for Nucleic Acid Structures: Limitations and Potential

Crystals (Basel), 2016-10, Vol.6 (10), p.125-125

2016

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RNAs Containing Carbocyclic Ribonucleotides

Organic letters, 2022-01, Vol.24 (2), p.525-530

2022

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Analysis of the Structure and Function of YfcG from Escherichia coli Reveals an Efficient and Unique Disulfide Bond Reductase

Biochemistry (Easton), 2009-07, Vol.48 (28), p.6559-6561

2009

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Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2′-deoxyguanosine

The Journal of biological chemistry, 2015-06, Vol.290 (26), p.15921-15933

2015

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Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs

Nucleic acids research, 2021-11, Vol.49 (19), p.10851

2021

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Shorter Is Better: The α‑(l)‑Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs

Journal of the American Chemical Society, 2023-09, Vol.145 (36), p.19691-19706

2023

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Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost

Biochemistry (Easton), 2020-12, Vol.59 (49), p.4627-4637

2020

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Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor

Bioorganic & medicinal chemistry letters, 2022-01, Vol.56, p.128479-128479, Article 128479

2022

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Structure and Stability of Ago2 MID‐Nucleotide Complexes: All‐in‐One (Drop) His6‐SUMO Tag Removal, Nucleotide Binding, and Crystal Growth

Current protocols, 2024-06, Vol.4 (6), p.e1088-n/a

2024

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Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections

The Journal of biological chemistry, 2010-01, Vol.285 (3), p.1773-1780

2010

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A Novel M 1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

ACS chemical neuroscience, 2018-09, Vol.9 (9), p.2274-2285

2018

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Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists

Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (23), p.5757-5764

2016

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Total Synthesis of Stemaphylline N-Oxide and Related C9a-Epimeric Analogues

Chemistry : a European journal, 2013-09, Vol.19 (36), p.11847-11852

2013

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Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5‑a]pyrimidines

ACS medicinal chemistry letters, 2017-10, Vol.8 (10), p.1110-1115

2017

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Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen

Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase

Computational redesign of a fluorogen activating protein with Rosetta

Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

Synthesis and Structure–Activity Relationships of 5,6,7-Substituted Pyrazolopyrimidines: Discovery of a Novel TSPO PET Ligand for Cancer Imaging

Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR

Evaluation of TSPO PET Ligands [18F]VUIIS1009A and [18F]VUIIS1009B: Tracers for Cancer Imaging

Cryo‐neutron crystallographic data collection and preliminary refinement of left‐handed Z‐DNA d(CGCGCG)

Methylation of Histone H3 by Coactivator-Associated Arginine Methyltransferase 1

Structure and Function of YghU, a Nu-Class Glutathione Transferase Related to YfcG from Escherichia coli

Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers

Phosphorus SAD Phasing for Nucleic Acid Structures: Limitations and Potential

RNAs Containing Carbocyclic Ribonucleotides

Analysis of the Structure and Function of YfcG from Escherichia coli Reveals an Efficient and Unique Disulfide Bond Reductase

Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2′-deoxyguanosine

Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs

Shorter Is Better: The α‑(l)‑Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs

Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost

Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor

Structure and Stability of Ago2 MID‐Nucleotide Complexes: All‐in‐One (Drop) His6‐SUMO Tag Removal, Nucleotide Binding, and Crystal Growth

Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections

A Novel M 1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists

Total Synthesis of Stemaphylline N-Oxide and Related C9a-Epimeric Analogues

Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5‑a]pyrimidines

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