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The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Nature communications, 2019-01, Vol.10 (1), p.6-6, Article 6

2019

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Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Nature chemical biology, 2015-03, Vol.11 (3), p.189

2015

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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

Nature cell biology, 2000-08, Vol.2 (8), p.531-539

2000

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Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Nature communications, 2020-09, Vol.11 (1), p.4680-4680, Article 4680

2020

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Interrogating the Druggability of the 2‑Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics

ACS chemical biology, 2016-07, Vol.11 (7), p.2002-2010

2016

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Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

Journal of Virology, 2009-10, Vol.83 (19), p.10058-10074

2009

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Comprehensive Proteomic Analysis of Human Par Protein Complexes Reveals an Interconnected Protein Network

The Journal of biological chemistry, 2004-03, Vol.279 (13), p.12804-12811

2004

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Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (17), p.6739-6744

2011

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A Tandem Guide RNA-Based Strategy for Efficient CRISPR Gene Editing of Cell Populations with Low Heterogeneity of Edited Alleles

CRISPR journal, 2020-04, Vol.3 (2), p.123

2020

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Multiple cyclophilins involved in different cellular pathways mediate HCV replication

Virology (New York, N.Y.), 2010-02, Vol.397 (1), p.43-55

2010

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Borg proteins control septin organization and are negatively regulated by Cdc42

Nature cell biology, 2001-10, Vol.3 (10), p.861-866

2001

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Biochemical characterization of USP7 reveals post‐translational modification sites and structural requirements for substrate processing and subcellular localization

The FEBS journal, 2007-08, Vol.274 (16), p.4256-4270

2007

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Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress

Journal of the American Heart Association, 2017-05, Vol.6 (5)

2017

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Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics

BMC cancer, 2012-01, Vol.12 (1), p.38-38, Article 38

2012

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Biological plasticity rescues target activity in CRISPR knock outs

Nature methods, 2019-11, Vol.16 (11), p.1087

2019

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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Nature (London), 2012-08, Vol.488 (7411), p.404-408

2012

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Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

Acta neuropathologica, 2017-05, Vol.133 (5), p.731-749

2017

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Assembly of Epithelial Tight Junctions Is Negatively Regulated by Par6

Current biology, 2002-02, Vol.12 (3), p.221-225

2002

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Functional interdependence of BRD4 and DOT1L in MLL leukemia

Nature structural & molecular biology, 2016-07, Vol.23 (7), p.673

2016

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A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

Nature cell biology, 2004-02, Vol.6 (2), p.97-105

2004

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Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4‑d]pyrimidin-4(3H)‑one Derivatives

Journal of medicinal chemistry, 2016-02, Vol.59 (4), p.1370-1387

2016

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PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

Chemistry & biology, 2013-07, Vol.20 (7), p.912-921

2013

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Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.623-628

2018

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The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

New IDH1 mutant inhibitors for treatment of acute myeloid leukemia

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Interrogating the Druggability of the 2‑Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics

Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

Comprehensive Proteomic Analysis of Human Par Protein Complexes Reveals an Interconnected Protein Network

Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)

A Tandem Guide RNA-Based Strategy for Efficient CRISPR Gene Editing of Cell Populations with Low Heterogeneity of Edited Alleles

Multiple cyclophilins involved in different cellular pathways mediate HCV replication

Borg proteins control septin organization and are negatively regulated by Cdc42

Biochemical characterization of USP7 reveals post‐translational modification sites and structural requirements for substrate processing and subcellular localization

Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress

Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics

Biological plasticity rescues target activity in CRISPR knock outs

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

Assembly of Epithelial Tight Junctions Is Negatively Regulated by Par6

Functional interdependence of BRD4 and DOT1L in MLL leukemia

A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4‑d]pyrimidin-4(3H)‑one Derivatives

PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3‑Amino-4-pyridine Carboxylate Derivatives

Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

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