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Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts

Cancer research communications, 2024-03, Vol.4 (3), p.834-848

2024

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Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replication

Molecular cancer therapeutics, 2023-08, Vol.22 (8), p.985

2023

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Abstract LB301: Molecular pharmacology and broad synergy of the novel ATR inhibitor M1774 with DNA damaging anticancer agents

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (8_Supplement), p.LB301-LB301

2023

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Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes

Nature communications, 2023-04, Vol.14 (1), p.1925-1925, Article 1925

2023

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Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation

iScience, 2022-11, Vol.25 (11), p.105338, Article 105338

2022

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SLFN11’s surveillance role in protein homeostasis

Oncoscience, 2022-07, Vol.9, p.35-37

2022

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TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor

Molecular cancer therapeutics, 2022-07, Vol.21 (7), p.1090-1102

2022

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Structural, molecular, and functional insights into Schlafen proteins

Experimental and Molecular Medicine, 2022, 54(0), , pp.730-738

2022

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Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway

iScience, 2021-10, Vol.24 (10), p.103173-103173, Article 103173

2021

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Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes

Nucleic acids research, 2021-10, Vol.49 (18), p.10493

2021

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Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11

Cancers, 2021-09, Vol.13 (18), p.4601

2021

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Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents

Molecular cancer therapeutics, 2021-08, Vol.20 (8), p.1431-1441

2021

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Abstract 1055: Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress and enhances the chemotherapeutic activity of widely used DNA damaging agents

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1055-1055

2021

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SLFN11 inactivation induces proteotoxic stress and sensitizes cancer cells to ubiquitin activating enzyme inhibitor TAK-243

Cancer research (Chicago, Ill.), 2021-06, Vol.81 (11), p.3067-3078

2021

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SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (6)

2021

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DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

Cell reports (Cambridge), 2020-12, Vol.33 (13), p.108569-108569, Article 108569

2020

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Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways

DNA repair, 2020-10, Vol.94, p.102926-102926, Article 102926

2020

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Abstract LB-121: The novel ATR inhibitor M4344 and CHK1 inhibitor SRA737 overcome chemoresistance in SLFN11-negative cells in combination treatment with DNA-damaging agents

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.LB-121-LB-121

2020

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Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

Cell reports (Cambridge), 2020-03, Vol.30 (12), p.4137-4151.e6

2020

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ERRATUM: Caveolin-1 Modulates Docetaxel-Induced Cell Death in Breast Cancer Cell Subtypes through Different Mechanisms

Cancer Research and Treatment, 2019, 51(3), , pp.1257-1257

2019

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A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment

Scientific reports, 2019-06, Vol.9 (1), p.8726-12, Article 8726

2019

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Conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks

Nucleic acids research, 2019-05, Vol.47 (8), p.3996

2019

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Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway

PLoS genetics, 2019-02, Vol.15 (2), p.e1007983-e1007983

2019

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Abstract 1403: PCNA-dependent cleavage and degradation of SDE2 regulates response to replication stress

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1403-1403

2017

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PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress

PLoS genetics, 2016-12, Vol.12 (12), p.e1006465

2016

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Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts

Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replication

Abstract LB301: Molecular pharmacology and broad synergy of the novel ATR inhibitor M1774 with DNA damaging anticancer agents

Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes

Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation

SLFN11’s surveillance role in protein homeostasis

TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor

Structural, molecular, and functional insights into Schlafen proteins

Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway

Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes

Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11

Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents

Abstract 1055: Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress and enhances the chemotherapeutic activity of widely used DNA damaging agents

SLFN11 inactivation induces proteotoxic stress and sensitizes cancer cells to ubiquitin activating enzyme inhibitor TAK-243

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways

Abstract LB-121: The novel ATR inhibitor M4344 and CHK1 inhibitor SRA737 overcome chemoresistance in SLFN11-negative cells in combination treatment with DNA-damaging agents

Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

ERRATUM: Caveolin-1 Modulates Docetaxel-Induced Cell Death in Breast Cancer Cell Subtypes through Different Mechanisms

A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment

Conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks

Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway

Abstract 1403: PCNA-dependent cleavage and degradation of SDE2 regulates response to replication stress

PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress

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