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Protein kinase C inhibitors as novel anticancer drugs

Expert opinion on investigational drugs, 2001-12, Vol.10 (12), p.2117-2140

2001

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Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats

The Journal of clinical investigation, 1997-07, Vol.100 (1), p.115-126

1997

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Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor

Science (American Association for the Advancement of Science), 1996-05, Vol.272 (5262), p.728-731

1996

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Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth

The Journal of clinical investigation, 1996-11, Vol.98 (9), p.2018-2026

1996

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Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases

Diabetes (New York, N.Y.), 1998-03, Vol.47 (3), p.464

1998

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Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway

American journal of physiology: endocrinology and metabolism, 1995-08, Vol.269 (2), p.E239-E246

1995

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Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development

Current medicinal chemistry, 1999-09, Vol.6 (9), p.877

1999

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Targeted Overexpression of Protein Kinase C β 2 Isoform in Myocardium Causes Cardiomyopathy

Proceedings of the National Academy of Sciences - PNAS, 1997-08, Vol.94 (17), p.9320-9325

1997

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(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and Related Analogues: Isozyme Selective Inhibitors of Protein Kinase Cβ

Journal of medicinal chemistry, 1996-07, Vol.39 (14), p.2664-2671

1996

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Antisense Protein Tyrosine Phosphatase 1B Reverses Activation of p38 Mitogen-Activated Protein Kinase in Liver of ob/ob Mice

Molecular endocrinology (Baltimore, Md.), 2003-06, Vol.17 (6), p.1131-1143

2003

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Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells

Biochemical and biophysical research communications, 2003-01, Vol.300 (2), p.261-267

2003

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Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets

European journal of pharmacology, 1999-12, Vol.386 (2), p.297-303

1999

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Synthesis of bisindolylmaleimides using a palladium catalyzed cross-coupling reaction

Bioorganic & medicinal chemistry letters, 1998-01, Vol.8 (1), p.47-50

1998

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Protein tyrosine phosphatase 1B inhibitors for diabetes

Nature reviews. Drug discovery, 2002-09, Vol.1 (9), p.696-709

2002

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PTP1B Antisense Oligonucleotide Lowers PTP1B Protein, Normalizes Blood Glucose, and Improves Insulin Sensitivity in Diabetic Mice

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (17), p.11357-11362

2002

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Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Journal of the American Chemical Society, 2003-04, Vol.125 (14), p.4087-4096

2003

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Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice

Diabetes (New York, N.Y.), 2003-01, Vol.52 (1), p.21-28

2003

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Fragment Screening and Assembly: A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor

Journal of medicinal chemistry, 2003-09, Vol.46 (20), p.4232-4235

2003

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The Protein Kinase C beta -Specific Inhibitor LY379196 Blocks TPA-Induced Monocytic Differentiation of HL60 Cells

Molecular carcinogenesis, 2000-03, Vol.27 (3), p.166-176

2000

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Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis

Diabetes (New York, N.Y.), 2002-08, Vol.51 (8), p.2405-2411

2002

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Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line

Molecular and cellular endocrinology, 2002-09, Vol.195 (1), p.109-118

2002

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Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (11), p.1857-1859

2003

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Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

Journal of medicinal chemistry, 2003-07, Vol.46 (16), p.3437-3440

2003

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In Vitro Enzymatic Assays of Protein Tyrosine Phosphatase 1B

Current Protocols in Pharmacology, 2001-08, Vol.13 (1), p.3.8.1-3.8.18

2001

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Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5543-5546

2004

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Protein kinase C inhibitors as novel anticancer drugs

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats

Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth

Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases

Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway

Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development

Targeted Overexpression of Protein Kinase C β 2 Isoform in Myocardium Causes Cardiomyopathy

(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and Related Analogues: Isozyme Selective Inhibitors of Protein Kinase Cβ

Antisense Protein Tyrosine Phosphatase 1B Reverses Activation of p38 Mitogen-Activated Protein Kinase in Liver of ob/ob Mice

Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells

Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets

Synthesis of bisindolylmaleimides using a palladium catalyzed cross-coupling reaction

Protein tyrosine phosphatase 1B inhibitors for diabetes

PTP1B Antisense Oligonucleotide Lowers PTP1B Protein, Normalizes Blood Glucose, and Improves Insulin Sensitivity in Diabetic Mice

Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice

Fragment Screening and Assembly: A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor

The Protein Kinase C beta -Specific Inhibitor LY379196 Blocks TPA-Induced Monocytic Differentiation of HL60 Cells

Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis

Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line

Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ

Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

In Vitro Enzymatic Assays of Protein Tyrosine Phosphatase 1B

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

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