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The ambiguous base-pairing and high substrate efficiency of T-705 (Favipiravir) Ribofuranosyl 5'-triphosphate towards influenza A virus polymerase

PloS one, 2013-07, Vol.8 (7), p.e68347

2013

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Structure of the Respiratory Syncytial Virus Polymerase Complex

Cell, 2019-09, Vol.179 (1), p.193-204.e14

2019

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Efficiency of Incorporation and Chain Termination Determines the Inhibition Potency of 2'-Modified Nucleotide Analogs against Hepatitis C Virus Polymerase

Antimicrobial agents and chemotherapy, 2014-07, Vol.58 (7), p.3636-3645

2014

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Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1862-1878

2015

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Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2'-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases

Antimicrobial agents and chemotherapy, 2015-12, Vol.59 (12), p.7504-7516

2015

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Synthesis and Anti-Hepatitis B Activities of 3'-Fluoro-2'-Substituted Apionucleosides

Molecules (Basel, Switzerland), 2022-04, Vol.27 (8), p.2413

2022

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Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs

Antiviral research, 2017-07, Vol.143, p.151-161

2017

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Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex

The Journal of biological chemistry, 2012-03, Vol.287 (13), p.10674-10683

2012

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Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

PLoS pathogens, 2015-06, Vol.11 (6), p.e1004995-e1004995

2015

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NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (5), p.E348-E357

2013

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Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

Communications biology, 2023-10, Vol.6 (1), p.1074-1074, Article 1074

2023

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Characterization of the Elongation Complex of Dengue Virus RNA Polymerase

The Journal of biological chemistry, 2011-01, Vol.286 (3), p.2067-2077

2011

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Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses

Virus research, 2017-04, Vol.234, p.21-33

2017

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Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C‑Nucleosides as Favipiravir (T-705) Analogues

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4611-4624

2016

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Discovery of gem-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors

Journal of medicinal chemistry, 2024-08, Vol.67 (16), p.13723-13736

2024

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Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′‑C‑methyluridine 5′-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4555-4570

2019

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Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10380-10395

2020

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Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY

The Journal of biological chemistry, 2011-01, Vol.286 (3), p.2067-2077

2011

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Structure of the Respiratory Syncytial Virus Polymerase Complex

Cell, 2019-09, Vol.179 (1), p.193-204.e14

2019

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Subgenomic promoter recognition by the norovirus RNA-dependent RNA polymerases

Nucleic acids research, 2015-01, Vol.43 (1), p.446-460

2015

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Role of a GAG Hinge in the Nucleotide-induced Conformational Change Governing Nucleotide Specificity by T7 DNA Polymerase

The Journal of biological chemistry, 2011-01, Vol.286 (2), p.1312-1322

2011

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Roles of catalytic residues on the nucleotide recognition domain of T7 DNA polymerase

The FASEB journal, 2008-03, Vol.22 (S1)

2008

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The Ambiguous Base-Pairing and High Substrate Efficiency of T-705

PloS one, 2013-07, Vol.8 (7), p.e68347

2013

Volltextzugriff (PDF)

NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (5), p.1575-1576

2013

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The ambiguous base-pairing and high substrate efficiency of T-705 (Favipiravir) Ribofuranosyl 5'-triphosphate towards influenza A virus polymerase

Structure of the Respiratory Syncytial Virus Polymerase Complex

Efficiency of Incorporation and Chain Termination Determines the Inhibition Potency of 2'-Modified Nucleotide Analogs against Hepatitis C Virus Polymerase

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2'-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases

Synthesis and Anti-Hepatitis B Activities of 3'-Fluoro-2'-Substituted Apionucleosides

Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs

Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase

Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase

Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses

Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C‑Nucleosides as Favipiravir (T-705) Analogues

Discovery of gem-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors

Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′‑C‑methyluridine 5′-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection

Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY

JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase

Structure of the Respiratory Syncytial Virus Polymerase Complex

Subgenomic promoter recognition by the norovirus RNA-dependent RNA polymerases

Role of a GAG Hinge in the Nucleotide-induced Conformational Change Governing Nucleotide Specificity by T7 DNA Polymerase

Roles of catalytic residues on the nucleotide recognition domain of T7 DNA polymerase

The Ambiguous Base-Pairing and High Substrate Efficiency of T-705

NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase

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