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New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription

Nucleic acids research, 2019-11, Vol.47 (20), p.10529-10542

2019

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Anti-tumor Activity of Toll-Like Receptor 7 Agonists

Frontiers in pharmacology, 2017-05, Vol.8, p.304-304

2017

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Breast Cancer Vaccine Containing a Novel Toll-like Receptor 7 Agonist and an Aluminum Adjuvant Exerts Antitumor Effects

International journal of molecular sciences, 2022-12, Vol.23 (23), p.15130

2022

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Selective activation of metabotropic glutamate receptor 7 blocks paclitaxel-induced acute neuropathic pain and suppresses spinal glial reactivity in rats

Psychopharmacology, 2021, Vol.238 (1), p.107-119

2021

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Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats

Biomedicine & pharmacotherapy, 2018-12, Vol.108, p.76-84

2018

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A novel TLR7 agonist as adjuvant to stimulate high quality HBsAg-specific immune responses in an HBV mouse model

Journal of translational medicine, 2020-03, Vol.18 (1), p.112-112, Article 112

2020

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Spatial and temporal differences of Chinese tourists’ travel demands to North Korea

PloS one, 2022-10, Vol.17 (10), p.e0272731-e0272731

2022

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Gastric cancer vaccines synthesized using a TLR7 agonist and their synergistic antitumor effects with 5-fluorouracil

Journal of translational medicine, 2018-05, Vol.16 (1), p.120-120, Article 120

2018

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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way

Journal for immunotherapy of cancer, 2022-10, Vol.10 (10), p.e004590

2022

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Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia

Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (16), p.7479-7484

2010

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CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Cell discovery, 2022-02, Vol.8 (1), p.9-9, Article 9

2022

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A Therapeutic Whole-Tumor-Cell Vaccine Covalently Conjugated with a TLR7 Agonist

Cells (Basel, Switzerland), 2022-06, Vol.11 (13), p.1986

2022

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Synthetic Toll-like receptor 7 ligand inhibits porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages

Antiviral research, 2016-07, Vol.131, p.9-18

2016

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Oxaliplatin-Based Platinum(IV) Prodrug Bearing Toll-like Receptor 7 Agonist for Enhanced Immunochemotherapy

ACS omega, 2020-01, Vol.5 (1), p.726-734

2020

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Synthesis and Evaluation of Conjugates of Novel TLR7 Inert Ligands as Self-Adjuvanting Immunopotentiators

ACS medicinal chemistry letters, 2015-03, Vol.6 (3), p.249-253

2015

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Inhibition of Cytokine Production by Hymenialdisine Derivatives

Journal of medicinal chemistry, 2004-07, Vol.47 (14), p.3700-3703

2004

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Conjugate of ibrutinib with a TLR7 agonist suppresses melanoma progression and enhances antitumor immunity

International journal of biological sciences, 2022, Vol.18 (1), p.166-179

2022

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Design, Synthesis, and Evaluation of 9-d-Ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones Bearing Alkyl Phosphate and α,α-Difluorophosphonate Substituents as Inhibitors of Riboflavin Synthase and Lumazine Synthase

Journal of organic chemistry, 2004-02, Vol.69 (3), p.601-612

2004

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A New Series of N-[2,4-Dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic Acid Derivatives as Inhibitors of Lumazine Synthase and Riboflavin Synthase: Design, Synthesis, Biochemical Evaluation, Crystallography, and Mechanistic Implications

Journal of organic chemistry, 2008-04, Vol.73 (7), p.2715-2724

2008

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Crystal Structure of Lumazine Synthase from Mycobacterium tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors

Biochemistry (Easton), 2005-03, Vol.44 (8), p.2746-2758

2005

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Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7

American journal of physiology. Regulatory, integrative and comparative physiology, 2008-07, Vol.295 (1), p.R123-R132

2008

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Does digital inclusive finance promote regional green inclusive growth?

Finance research letters, 2024-04, Vol.62, p.105163, Article 105163

2024

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A chemical conjugation of JQ‐1 and a TLR7 agonist induces tumoricidal effects in a murine model of melanoma via enhanced immunomodulation

International journal of cancer, 2021-01, Vol.148 (2), p.437-447

2021

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Design, Synthesis, and Biochemical Evaluation of 1,5,6,7-Tetrahydro-6,7-dioxo-9-d-Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase

Journal of organic chemistry, 2005-09, Vol.70 (20), p.8162-8170

2005

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Discovery of novel ibrutinib analogues to treat malignant melanoma

Bioorganic chemistry, 2021-12, Vol.117, p.105419, Article 105419

2021

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New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription

Anti-tumor Activity of Toll-Like Receptor 7 Agonists

Breast Cancer Vaccine Containing a Novel Toll-like Receptor 7 Agonist and an Aluminum Adjuvant Exerts Antitumor Effects

Selective activation of metabotropic glutamate receptor 7 blocks paclitaxel-induced acute neuropathic pain and suppresses spinal glial reactivity in rats

Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats

A novel TLR7 agonist as adjuvant to stimulate high quality HBsAg-specific immune responses in an HBV mouse model

Spatial and temporal differences of Chinese tourists’ travel demands to North Korea

Gastric cancer vaccines synthesized using a TLR7 agonist and their synergistic antitumor effects with 5-fluorouracil

PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way

Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

A Therapeutic Whole-Tumor-Cell Vaccine Covalently Conjugated with a TLR7 Agonist

Synthetic Toll-like receptor 7 ligand inhibits porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages

Oxaliplatin-Based Platinum(IV) Prodrug Bearing Toll-like Receptor 7 Agonist for Enhanced Immunochemotherapy

Synthesis and Evaluation of Conjugates of Novel TLR7 Inert Ligands as Self-Adjuvanting Immunopotentiators

Inhibition of Cytokine Production by Hymenialdisine Derivatives

Conjugate of ibrutinib with a TLR7 agonist suppresses melanoma progression and enhances antitumor immunity

Design, Synthesis, and Evaluation of 9-d-Ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones Bearing Alkyl Phosphate and α,α-Difluorophosphonate Substituents as Inhibitors of Riboflavin Synthase and Lumazine Synthase

A New Series of N-[2,4-Dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic Acid Derivatives as Inhibitors of Lumazine Synthase and Riboflavin Synthase: Design, Synthesis, Biochemical Evaluation, Crystallography, and Mechanistic Implications

Crystal Structure of Lumazine Synthase from Mycobacterium tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors

Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7

Does digital inclusive finance promote regional green inclusive growth?

A chemical conjugation of JQ‐1 and a TLR7 agonist induces tumoricidal effects in a murine model of melanoma via enhanced immunomodulation

Design, Synthesis, and Biochemical Evaluation of 1,5,6,7-Tetrahydro-6,7-dioxo-9-d-Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase

Discovery of novel ibrutinib analogues to treat malignant melanoma

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