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SIRT1 and p53, effect on cancer, senescence and beyond

Biochimica et biophysica acta, 2010-08, Vol.1804 (8), p.1684-1689

2010

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The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2

Oncogene, 2021-03, Vol.40 (9), p.1706-1720

2021

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SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation

Cancer research (Chicago, Ill.), 2018-01, Vol.78 (2), p.372-386

2018

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PYCR, a key enzyme in proline metabolism, functions in tumorigenesis

Amino acids, 2021-12, Vol.53 (12), p.1841-1850

2021

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Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress

Nucleic acids research, 2018-10, Vol.46 (18), p.9601-9616

2018

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NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation

Cell death and differentiation, 2022-04, Vol.29 (4), p.846-860

2022

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NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2

EMBO reports, 2016-03, Vol.17 (3), p.349-366

2016

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Parkin Regulates the Activity of Pyruvate Kinase M2

The Journal of biological chemistry, 2016-05, Vol.291 (19), p.10307-10317

2016

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Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (29), p.10684-10689

2014

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Citrate synthase desuccinylation by SIRT5 promotes colon cancer cell proliferation and migration

Biological chemistry, 2020-08, Vol.401 (9), p.1031-1039

2020

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C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex

Molecular cell, 2019-09, Vol.75 (6), p.1299-1314.e6

2019

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Structural and functional insights into the lipid regulation of human anion exchanger 2

Nature communications, 2024-01, Vol.15 (1), p.759-759, Article 759

2024

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Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A

Molecular cell, 2019-06, Vol.74 (6), p.1250-1263.e6

2019

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SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism

Neoplasia (New York, N.Y.), 2019-07, Vol.21 (7), p.665-675

2019

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RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA)

The Journal of biological chemistry, 2008-10, Vol.283 (43), p.29037-29044

2008

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

Aging cell, 2007-12, Vol.6 (6), p.759-767

2007

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PKM2 aggregation drives metabolism reprograming during aging process

Nature communications, 2024-07, Vol.15 (1), p.5761-16, Article 5761

2024

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Acetylation of BLM protein regulates its function in response to DNA damage

RSC advances, 2017-01, Vol.7 (87), p.5531-5538

2017

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RBM15 Functions in Blood Diseases

Current cancer drug targets, 2016-09, Vol.16 (7), p.579-585

2016

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Activation of Stat3 Sequence-specific DNA Binding and Transcription by p300/CREB-binding Protein-mediated Acetylation

The Journal of biological chemistry, 2005-03, Vol.280 (12), p.11528-11534

2005

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Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses

Cell, 2005-11, Vol.123 (3), p.437-448

2005

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Increased Amino Acid Uptake Supports Autophagy-Deficient Cell Survival upon Glutamine Deprivation

Cell reports (Cambridge), 2018-06, Vol.23 (10), p.3006-3020

2018

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Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation

The Journal of biological chemistry, 2008-03, Vol.283 (12), p.7590-7598

2008

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Acetylation of p53 Inhibits Its Ubiquitination by Mdm2

The Journal of biological chemistry, 2002-12, Vol.277 (52), p.50607-50611

2002

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SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

Molecular cell, 2010-07, Vol.39 (2), p.247-258

2010

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SIRT1 and p53, effect on cancer, senescence and beyond

The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2

SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation

PYCR, a key enzyme in proline metabolism, functions in tumorigenesis

Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress

NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation

NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2

Parkin Regulates the Activity of Pyruvate Kinase M2

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

Citrate synthase desuccinylation by SIRT5 promotes colon cancer cell proliferation and migration

C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex

Structural and functional insights into the lipid regulation of human anion exchanger 2

Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A

SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism

RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA)

SIRT1 transgenic mice show phenotypes resembling calorie restriction

PKM2 aggregation drives metabolism reprograming during aging process

Acetylation of BLM protein regulates its function in response to DNA damage

RBM15 Functions in Blood Diseases

Activation of Stat3 Sequence-specific DNA Binding and Transcription by p300/CREB-binding Protein-mediated Acetylation

Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses

Increased Amino Acid Uptake Supports Autophagy-Deficient Cell Survival upon Glutamine Deprivation

Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation

Acetylation of p53 Inhibits Its Ubiquitination by Mdm2

SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

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